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Cyclin-dependent kinase inhibitors as potential targeted anticancer agents

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Summary

Cyclin-dependent kinases (CDKs) are core components of the cell cycle machinery that govern the transition between phases during cell cycle progression. Genes involved in cell cycle are frequently mutated in human cancer and deregulated CDK activity represents a hallmark of malignancy. This knowledge provides a rationale for regarding CDKs and their associated molecules as potential targets for new drug development in anticancer research. The present article will review the most relevant CDK inhibitors with emphasis on the newer molecules in clinical development and the biological rationale of this therapeutic approach.

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Authors and Affiliations

  1. Medical Oncology Department, Centro Integral Oncologico “Clara Campal”, C/ Oña 10, 28050, Madrid, Spain

    Ivan Diaz-Padilla & Ignacio Duran

  2. Princess Margaret Hospital, Toronto, Canada

    Lillian L. Siu

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  1. Ivan Diaz-Padilla
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  2. Lillian L. Siu
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  3. Ignacio Duran
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Correspondence to Ignacio Duran.

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Diaz-Padilla, I., Siu, L.L. & Duran, I. Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest New Drugs 27, 586–594 (2009). https://doi.org/10.1007/s10637-009-9236-6

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