Abstract
Purpose To test a framework that describes how the multifocal visual-evoked potential (mfVEP) technique is used in a particular glaucoma practice. Methods In this prospective, descriptive study, glaucoma suspects, ocular hypertensives and glaucoma patients were referred for mfVEP testing by a single glaucoma specialist over a 2-year period. All patients underwent standard automated perimetry (SAP) and mfVEP testing within 3 months. Two hundred and ten patients (420 eyes) were referred for mfVEP testing for the following reasons: (1) normal SAP tests suspected of early functional loss (ocular hypertensives, n = 43; and glaucoma suspects on the basis of suspicious optic disks, n = 52); (2) normal-tension glaucoma patients with suspected central SAP defects (n = 33); and (3) SAP abnormalities needing confirmation (n = 82). Results All the glaucoma suspects with normal SAP and mfVEP results remained untreated. Of those with abnormal mfVEP results, 68 % (15/22) were treated because the abnormal regions on the mfVEP were consistent with the abnormal regions seen during clinical examination of the optic disk. The mfVEP was abnormal in 86 % (69/80) of eyes with glaucomatous optic neuropathy and SAP damage, even though it did not result in an altered treatment regimen. In NTG patients, the mfVEP showed central defects in 44 % (12 of 27) of the eyes with apparently normal central fields and confirmed central scotomata in 92 % (36 of 39), leading to more rigorous surveillance of these patients. Conclusions In a clinical practice, the mfVEP was used when clinical examination and subjective visual fields provided insufficient or conflicting information. This information influenced clinical management.
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Acknowledgments
This study was supported in part by grants EY09076 and EY02115 from the National Institutes of Health, Bethesda, MD; the Kwie Ding and Mae Sun Wang Research Fund of the New York Glaucoma Research Institute, New York, NY; and the Edith C. Blum Foundation, New York, NY (CGDM).
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De Moraes, C.G., Liebmann, J.M., Ritch, R. et al. Clinical use of multifocal visual-evoked potentials in a glaucoma practice: a prospective study. Doc Ophthalmol 125, 1–9 (2012). https://doi.org/10.1007/s10633-012-9324-3
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DOI: https://doi.org/10.1007/s10633-012-9324-3