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Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells

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Abstract

Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early pathogenesis of the disease. To clarify the mechanism of maintaining calcium homeostasis in the cell and pathological processes caused by calcium overload would help to research directly targeted therapeutic agents. We will specifically review the following: intracellular calcium homeostasis and regulation, the occurrence of calcium overload in acinar cells, the role of calcium overload in the pathogenesis of AP, the treatment strategy proposed for calcium overload.

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Abbreviations

AP:

Acute pancreatitis

Ca2+ :

Calcium

PACs:

Pancreatic acinar cells

[Ca2+]e :

Extracellular Ca2+ concentration

[Ca2+]c :

The cytosolic Ca2+ concentration

PM:

Plasma membrane

ER:

Endoplasmic reticulum

SR:

Sarcoplasmic reticulum

InsP3 :

Inositol 1,4,5-trisphosphate

InsP3Rs:

InsP3 receptors

RyRs:

Ryanodine receptors

FAEEs:

Fatty acid ethyl esters

PIP2:

Phosphatidylinositol(4,5)bisphosphate

DG:

Diacylglycerol

IICR:

InsP3-induced Ca2+ release

InsP3R1:

The type 1 InsP3R

InsP3R2:

The type 2 InsP3R

InsP3R3:

The type 3 InsP3R

ATP:

Adenosine triphosphate

WT:

Wild-type

ZGs:

Zymogen granules

cADPR:

Cyclic ADP ribose

CICR:

Calcium-induced calcium release

SCaMPER:

Sphingolipid Ca2+ release-mediating protein of the endoplasmic reticulum

VOCCs:

Voltage-operated Ca2+ channels

SOCCs:

Store-operated Ca2+ channels

TRPC:

Transient receptor potential channel

STIM1:

Stromal interaction molecule 1

Ach:

Acetylcholine

ROCCs:

Receptor-operated Ca2+ channels

PKC:

Protein kinase C

MPO:

Myeloperoxidase

PMCA:

Ca2+-ATPase on the plasma membrane

[Ca2+]i :

Intracellular calcium concentration

NCX:

Na+/Ca2+ exchange

SERCA:

SR/ER Ca2+-ATPase

TAP:

Trypsinogen-activating peptide

MPTP:

Mitochondrial permeability transition pore

PLA2:

Phospholipase A2

TXA2:

Thromboxane A2

PGI2:

Prostacyclin

PAF:

Platelet-activating factor

xDH:

Xanthine dehydrogenase

XOD:

Xanthine oxidase

OFRs:

Oxygen free radicals

ROS:

Reactive oxygen species

CRAC:

Calcium release activation of calcium

NAC:

N-acetylcysteine

sAC:

Soluble adenylyl cyclase

cAMP:

Cyclic adenosine monophosphate

LDH:

Lactate dehydrogenase

Cyp D:

Cyclophilin D

PACs:

Pancreatic acinar cells

∆Ψm :

Mitochondrial membrane potential

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Acknowledgment

This work was supported by the Affiliated Hospital of Southwest Medical University.

Funding

This article was funded by the following fund project: “The role and mechanism of calcium channels in hyperlipidemia acute pancreatitis,” project number: 2015LZCYD-S04 (6/15).

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Authors and Affiliations

  1. Southwest Medical University, Zhongshan Street, Jiangyang District, Luzhou, 64600, Sichuan, China

    Siqing Feng, Qiongqiong Wei & Xiaomei Huang

  2. Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, 64600, Sichuan, China

    Qing Hu, Xi Zhou, Gang Luo, Mingming Deng & Muhan Lü

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  1. Siqing Feng
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  2. Qiongqiong Wei
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  3. Qing Hu
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  4. Xiaomei Huang
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  5. Xi Zhou
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  6. Gang Luo
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  7. Mingming Deng
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  8. Muhan Lü
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Correspondence to Mingming Deng or Muhan Lü.

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Feng, S., Wei, Q., Hu, Q. et al. Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells. Dig Dis Sci 64, 25–38 (2019). https://doi.org/10.1007/s10620-018-5297-8

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  • DOI: https://doi.org/10.1007/s10620-018-5297-8

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