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Beneficial Effect of Splanchnic Nerve Transection and Harmful Effect of Vagotomy on Acute Necrotizing Pancreatitis in the Dog

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Abstract

Background

The nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. However, the influence of visceral nerve (VN) on acute necrotizing pancreatitis (ANP) has drawn little attention.

Aim

To investigate the influence of VN on the pathophysiological process of ANP in dogs.

Methods

The dogs were divided into a sham operation (SO) group, ANP group, ANP + vagal nerve trunk transection (VNTT) group, and ANP + greater splanchnic nerve transection (GSNT) group. The VNTT and GSNT groups underwent VNTT and GSNT respectively immediately after ANP induction. The levels of serum pancreatic amylase (AMY), calcium, high-sensitivity C-reactive protein (HCRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-10 (IL-10) were monitored dynamically and the pathological examinations of the pancreas was performed at postoperative day 7.

Results

All serum parameters among the four groups showed no differences before the experiment (p > 0.05). At different postoperative times, the serum TNF-α, IL-1β, HCRP, and AMY were significantly increased, however, the serum calcium and IL-10 had dropped in the ANP group versus SO group (p < 0.05); an alike variation trend occurred between the VNTT group and ANP group (p < 0.05); an opposite variation trend occurred between the GSNT group and the ANP group (p < 0.05). The pancreas pathological scoring of VNTT group was highest in the four groups (p < 0.05) and GSNT group was lower versus ANP group (p < 0.05).

Conclusions

The GSNT has been shown to alleviate development of ANP, however, VNTT may exacerbate the ANP.

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Acknowledgments

The authors gratefully acknowledge the assistance of Dr. Jianqiang Mi in histopathological experiments. This study was funded by Cultivating Fund of Henan University of Science and Technology.

Conflict of interest

There are no potential conflicts of interest to disclose for all authors.

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Authors and Affiliations

  1. Department of General Surgery, First Affiliated Hospital of Henan University of Science and Technology, Jinghua Road No. 24, Luoyang, 471003, China

    Jun-Jun Sun, Zhi-Jie Chu, Yu-Ming Zhang, Shi-Fang Qi, Yong-Chao Chang, Shi-Yong Xin, Wei-Feng Liu, Yan-Hui Yang, Xiao-Hui Zhang, Cheng Yang & Tian-Bao Yang

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  1. Jun-Jun Sun
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  2. Zhi-Jie Chu
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  3. Yu-Ming Zhang
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Correspondence to Jun-Jun Sun.

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Sun, JJ., Chu, ZJ., Zhang, YM. et al. Beneficial Effect of Splanchnic Nerve Transection and Harmful Effect of Vagotomy on Acute Necrotizing Pancreatitis in the Dog. Dig Dis Sci 60, 118–126 (2015). https://doi.org/10.1007/s10620-014-3315-z

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  • DOI: https://doi.org/10.1007/s10620-014-3315-z

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