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Impaired Sleep Quality in Crohn’s Disease Depends on Disease Activity

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Abstract

Background

Little is known concerning the relationship of disease activity and sleep disturbances in inflammatory bowel disease (IBD) and specifically in patients with Crohn’s disease.

Aim

This study examined the prevalence of poor sleep quality in patients with active and inactive Crohn’s disease compared with healthy controls.

Methods

Participants included 108 patients with Crohn’s disease attending the IBD clinic of a tertiary medical center in 2009–2010 and 36 healthy volunteers. All prospectively completed a demographic questionnaire and the Pittsburgh sleep quality index (PSQI). Patients with Crohn’s disease completed the Crohn’s disease activity index (CDAI) and were divided into two groups accordingly: inactive disease (CDAI ≤150) and active disease (CDAI >150). Data on disease duration, medications, complications, and treatment were collected from the medical files.

Results

Seventy-one patients had inactive Crohn’s disease and 37 had active disease. All three groups were similar in mean age, sex distribution, and body mass index. Mean duration of Crohn’s disease was 10.22 ± 8.6 years; 40 patients (37 %) had ileal disease, 16 (15 %) colonic disease, and 56 (50 %) ileo-colonic disease. Patients with active disease had a significantly higher mean ± SD global score on the PSQI (8.6 ± 2.4; indicating poorer sleep quality) than patients with inactive disease (4.6 ± 1.9) or control subjects (5.1 ± 1.7) (p < 0.0001 for both), with no significant difference between the inactive-disease and control groups. The correlation between the CDAI and PSQI scores was statistically significant (p < 0.001).

Conclusions

Impaired sleep quality is associated with active Crohn’s disease, but not inactive disease.

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Acknowledgments

The authors thank Gloria Ginzach and Melanie Kawe of the Editorial Board of Rabin Medical Center for editing and preparing the manuscript.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, 49100, Petach Tikva, Israel

    Rachel Gingold-Belfer, Yaron Niv, Gerald Fraser & Ram Dickman

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Rachel Gingold-Belfer, Nir Peled, Yaron Niv, Gerald Fraser & Ram Dickman

  3. Thoracic Cancer Research and Detection Center, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel

    Nir Peled

  4. The Academic College of Tel Aviv-Yaffo, 61083, Tel Aviv, Israel

    Sigal Levy

  5. Sleep Laboratory, Assuta Medical Center, 69710, Tel Aviv, Israel

    Neriel Katz

  6. Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, 44109, USA

    Ronnie Fass

Authors
  1. Rachel Gingold-Belfer
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  2. Nir Peled
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  3. Sigal Levy
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  4. Neriel Katz
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  5. Yaron Niv
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  6. Ronnie Fass
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  7. Gerald Fraser
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  8. Ram Dickman
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Corresponding author

Correspondence to Ram Dickman.

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Gingold-Belfer, R., Peled, N., Levy, S. et al. Impaired Sleep Quality in Crohn’s Disease Depends on Disease Activity. Dig Dis Sci 59, 146–151 (2014). https://doi.org/10.1007/s10620-013-2890-8

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  • DOI: https://doi.org/10.1007/s10620-013-2890-8

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