Abstract
To elucidate the clinical features of functional dyspepsia (FD), patients with FD were compared with patients with peptic ulcer. Fifty-eight FD and fifty-nine peptic ulcer patients were compared with respect to clinical features and patient background. In the FD group, symptoms of dyspepsia, especially upper abdominal fullness and nausea, were more common than in the peptic ulcer group. The FD group complained greater distress (severity of the most distressing symptom; P < .001) and showed higher State-Trait Anxiety Inventory (STAI) scores (trait-anxiety score; P < .05). A higher proportion of FD patients had consulted another physician (P < .01). Even when subjects from the FD and peptic ulcer group in this study were matched for age and gender and compared with respect to these variables, almost the same characteristics were seen. These results indicate that FD markedly decreases quality of life in a variety of aspects.
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Drossman DA, Creed FH, Olden KW, Svedlund J, Toner BB, Whitehead WE (1999) Psychosocial aspect of the functional gastrointestinal disorder. Gut 45(Suppl 2):II25–30
Dimenas E, Glise H, Hallerback B, Hernqvist H, Svedlund J, Wiklund I (1993) Quality of life in patients with upper gastrointestinal symptoms. An improved evaluation of treatment regimens? Scand J Gastroenterol 28:681–687
Wiklund IK, Junghard O, Grace E, Talley NJ, Kamm M, Veldhuyzen van Zanten S, Pare P, Chiba N, Leddin DS, Bigard MA, Colin R, Schoenfeld P (1998) Quality of life in Reflux and Dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg 583(Suppl 2):41–49
Chassany O, Marquis P, Scherrer B, Read NW, Finger T, Bergmann JF, Fraitag B, Geneve J, Caulin C (1999) Validation of quality of life questionnaire for functional digestive disorders. Gut 44:527–533
Spielberger CD, Goursuch RL, Lushene RE (1983) Manual for the State Trait Anxiety Inventory. Mountain View, CA, Consulting Psychologist Press
Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GNJ (1999) Functional gastroduodenal disorders. Gut 45(Suppl 2):II37–42
Wong D (1977) Whaley and Wong's essential of pediatric nursing (5th ed). St. Louis, MO, Mosby-Year Book, p 1215
Enck P, Dubois D, Marquis P (1999) Quality of life in patients with upper gastrointestinal symptoms results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl 231:48–54
Haycox A, Einarson T, Eggleston A (1999) The health economic impact of upper gastrointestinal symptoms in the general population: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl 231:38–47
Haug TT, Svebak S, Wilhelmsen I, Berstad A, Ursin H (1994) Psychological factors and somatic symptoms in functional dyspepsia. A comparison with duodenal ulcer and healthy controls. J Psychosom Res 38:281–291
Wilhelmsen I, Haug TT, Ursin H, Berstad A (1995) Discriminant analysis of factors distinguishing patients with functional dyspepsia with duodenal ulcer. Significance of somatization. Dig Dis Sci 40:1105–1111
Hongo M, Nomura T (2002) Brain-gut interaction and pathophysiology of functional dyspepsia. J Clin Exp Med 201:87–91
Bennett EJ, Piesse C, Palmer K, Badcock C-A, Tennant CC, Kellow JE (1998) Functional gastrointestinal disorders: psychological, social, and somatic features. Gut 42:414–420
Quartero AO, Wit NJ, Lodder AC, Numans ME, Smout AJPM, Hoes AW (1998) Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis. Dig Dis Sci 43:2028–2033
Wilmer A, Van Cutsem E, Andrioli A, Tack J, Coremans G, Janssens J (1998) Ambulatory gastro-jejunal manometry in severe motility-like dyspepsia: lack of correlation between dysmotility, symptoms and gastric emptying. Gut 42:235–242
Thumshirn M (2002) Pathophysiology of functional dyspepsia. Gut 51(Suppl I):I63–66
Tack J, Caene P, Fischer B, Piessevaux H, Janssens J (2001) Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia. Gastroenterology 121:526–535
Caldarella MP, Azpiroz F, Malagelada JR (2003) Antro-fundic dysfunction in functional dyspepsia. Gastroenterology 124:1220–1229
Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM (1991) Neurohumoral factor in functional dyspepsia: insights on pathophysiological mechanism. Gastroenterology 100:1311–1318
Mayaer EA, Gebhart GF (1994) Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 104:271–293
Coffin B, Azpiroz F, Guarner F, Malagelada JR (1994) Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology 107:1345–1351
Salt GAM, Samson M, Roelofs JMN, Van Berg Heangouwen GP, Samsom M, Verhagen MAMT, van Berge Henegrouwen GP, Smout AJPM (1999) Abdominal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. Gastroenterology 116:515–520
Kanazawa M, Nomura T, Fukudo S, Hongo M (2000) Abnormal visceral perception in patients with functional dyspepsia: use of cerebral potentials evoked by electrical stimulation of the oesophagus. Neurogastgroenterol Motil 12:87–94
Hou XH, Li Q, Zhu L, Xie X, Chen JDZ (2004) Correlation of gastric emptying with various thresholds of sensation in healthy controls and patients with functional dyspepsia. Dig Dis Sci 49:188–195
Kawakami H, Hongo M, Okuno Y, Yamada M, Nishimura N, Fukudo S (1995) Personality deviation and gastric motility in patients with functional dyspepsia. J Clin Gastroenterol 21(Suppl 1):S179–184
Ariz Q, Thompson DG (1998) Brain-gut axis in health and disease. Gastroenterology 114:559–578
Bennett EJ, Kellow JE, Cowen H, Scott AM, Shuter B, Langeluddecke PM, Hoschl R, Jones MP, Tennant CC (1992) Suppression of anger and gastric emptying in patients with functional dyspepsia. Scand J Gastroenterol 27:869–874
Veldhuyzen van Zanten SJO, Cleary C, Tally NJ, Peterson T, Nyren O, Bradly LA, Verlinden M, Tytgat GNJ (1996) Drug treatment of functional dyspepsia: A systematic analysis of trial methodology with recommendations for design of future trials. Am J Gastroenterol 91:660–673
Mearin F, Balboa A, Zarate N, Cucala M, Malagelada JR (1999) Placebo in functional dyspepsia: symptomatic, gastrointestinal motor and gastric sensorial responses. Am J Gastroenterol 94:116–125
Haug TT, Wilhelmsen I, Svebak S, Berstad A, Ursin H (1994) Psychotherapy in functional dyspepsia. J Psychosom Res 38:735–744
Hamilton J, Guthrie E, Creed F, Thompson D, Tomenson B, Bennett R, Moriarty K, Stephens W, Liston R (2000) A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia. Gastroenterology 119:661–669
Calvert EL, Houghton LA, Cooper P, Morris J, Whorwell PJ (2002) Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology 123:1778–1785
Poitras MR, Verrier P, So C, Paquet S, Bouin M, Poitras P (2002) Group counseling psychotherapy for patients with functional gastrointestinal disorders. Dig Dis Sci 47:1297–1307
Soo S, Moayyedi P, Deeks J, Delaney B, Lewis M, Forman D (2001) Psychological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev 4:CD002301
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Nakao, H., Konishi, H., Mitsufuji, S. et al. Comparison of Clinical Features and Patient Background in Functional Dyspepsia and Peptic Ulcer. Dig Dis Sci 52, 2152–2158 (2007). https://doi.org/10.1007/s10620-006-9204-3
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DOI: https://doi.org/10.1007/s10620-006-9204-3