Abstract
We demonstrate immunomodulatory effects, especially those involving murine intestinal IgA secretion, in Peyer's patch cells following oral administration of Bifidobacterium immunomodulator (BIM) derived from sonicated B. pseudocatenulatum 7041. BALB/c mice were administered BIM orally for 7 consecutive days. The PP cells demonstrated upregulated secretion of total IgA including BIM-specific IgA following BIM administration. In observing the response of PP cells co-cultured with BIM, we found enhanced secretion of interferon-γ (IFN-γ) and interleukin (IL)-6 in the CD4+ T cells. In contrast, IL-12 secretion by Thy1.2− PP cells was enhanced, but secretion of IFN-γ, IL-5, and IL-6 was not significantly affected. Furthermore, the population of CD4+ CD45RBhigh T cells in PP increased following oral administration of BIM. These data suggest that CD4+ T cells were affected by BIM administration. Overall, the results show that oral administration of BIM induced CD4+ PP cells to change their expression of cell surface antigen and cytokine production.
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Abbreviations
- APCs:
-
antigen presenting cells
- BIM:
-
Bifidobacterium immunomodulater
- DC:
-
dendritic cells
- IFN-c:
-
interferon-c
- IL:
-
interleukin
- Mφ:
-
macrophage
- PP:
-
PeyerÆs patch
- Th1:
-
type 1 helper T
- Th2:
-
type 2 helper T
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Nakanishi, Y., Hosono, A., Hiramatsu, Y. et al. Characteristic Immune Response in Peyer’s Patch Cells Induced by Oral Administration of Bifidobacterium Components. Cytotechnology 47, 69–77 (2005). https://doi.org/10.1007/s10616-005-3776-1
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DOI: https://doi.org/10.1007/s10616-005-3776-1