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Synthetic Transformations of Higher Terpenoids. 42*. Synthesis and Biological Activity of (Arylsulfonylureido)Diterpenoids with Various Substituents on the Aryl Fragment

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Chemistry of Natural Compounds Aims and scope

The first (arylsulfonylureido)-substituted derivatives of tricyclic diterpenoids were synthesized by the reaction of isopimaric acid isocyanate with sulfonamides of various structures. The molecular structures of 11c and 12 were proved by X-ray crystal structure analyses. The anti-inflammatory activity was studied in a histamine inflammatory edema model. The activity depended significantly on the substituent in the sulfonylureido fragment.

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Acknowledgment

The studies were financially supported by the Russian Foundation for Basic Research in the framework of science project No. 19-33-60043 and a state task (topics Nos. 1021051402785-4-1.4.1 and 1021051503128-9-1.4.1). We thank the Khimiya Research Center for Collective Use, SB, RAS, for making the spectral and analytical measurements.

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Authors and Affiliations

  1. Novosibirsk State Pedagogical University, 28 Vilyuiskaya St, Novosibirsk, 630126, Russia

    M. A. Gromova

  2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Prosp. Lavrent’eva, 630090, Novosibirsk, Russia

    Yu.V. Kharitonov, T. V. Rybalova, S. A. Borisov, T. G. Tolstikova & E. E. Shults

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  1. M. A. Gromova
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  2. Yu.V. Kharitonov
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  3. T. V. Rybalova
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  4. S. A. Borisov
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  5. T. G. Tolstikova
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  6. E. E. Shults
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Correspondence to E. E. Shults.

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For 41, see the literature [1].

Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2023, pp. 250–261

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Gromova, M.A., Kharitonov, Y., Rybalova, T.V. et al. Synthetic Transformations of Higher Terpenoids. 42*. Synthesis and Biological Activity of (Arylsulfonylureido)Diterpenoids with Various Substituents on the Aryl Fragment. Chem Nat Compd 59, 296–308 (2023). https://doi.org/10.1007/s10600-023-03981-1

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