The first (arylsulfonylureido)-substituted derivatives of tricyclic diterpenoids were synthesized by the reaction of isopimaric acid isocyanate with sulfonamides of various structures. The molecular structures of 11c and 12 were proved by X-ray crystal structure analyses. The anti-inflammatory activity was studied in a histamine inflammatory edema model. The activity depended significantly on the substituent in the sulfonylureido fragment.
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Acknowledgment
The studies were financially supported by the Russian Foundation for Basic Research in the framework of science project No. 19-33-60043 and a state task (topics Nos. 1021051402785-4-1.4.1 and 1021051503128-9-1.4.1). We thank the Khimiya Research Center for Collective Use, SB, RAS, for making the spectral and analytical measurements.
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For 41, see the literature [1].
Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2023, pp. 250–261
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Gromova, M.A., Kharitonov, Y., Rybalova, T.V. et al. Synthetic Transformations of Higher Terpenoids. 42*. Synthesis and Biological Activity of (Arylsulfonylureido)Diterpenoids with Various Substituents on the Aryl Fragment. Chem Nat Compd 59, 296–308 (2023). https://doi.org/10.1007/s10600-023-03981-1
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DOI: https://doi.org/10.1007/s10600-023-03981-1