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Synthesis and Antioxidant Properties of Hydroxycinnamic Acid Derivatives Containing Isobornyl Substituents

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Chemistry of Natural Compounds Aims and scope

New hydroxycinnamic acid derivatives were synthesized by reacting malonic acid and 4-hydroxybenzaldehydes with isobornyl and/or alkyl substituents. The antiradical, antioxidant, and membrane-protective activities were assessed in various in vitro models. The bulk of the substituent(s) in the o-position(s) relative to the phenol hydroxyl had a substantial effect on the antioxidant properties of the tested acids.

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Acknowledgment

The research was financially supported by the RFBR in the framework of science Project No. 18-03-00950_a.

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 48 Pervomaiskaya St., Syktyvkar, Russian Federation, 167000

    I. A. Dvornikova, E. V. Buravlev, I. V. Fedorova, I. Yu. Chukicheva & A. V. Kuchin

  2. Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya St., Syktyvkar, Russian Federation, 167982

    O. G. Shevchenko

Authors
  1. I. A. Dvornikova
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  2. E. V. Buravlev
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  3. I. V. Fedorova
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  4. O. G. Shevchenko
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  5. I. Yu. Chukicheva
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  6. A. V. Kuchin
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Corresponding author

Correspondence to I. A. Dvornikova.

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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2019, pp. 565–570.

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Dvornikova, I.A., Buravlev, E.V., Fedorova, I.V. et al. Synthesis and Antioxidant Properties of Hydroxycinnamic Acid Derivatives Containing Isobornyl Substituents. Chem Nat Compd 55, 658–664 (2019). https://doi.org/10.1007/s10600-019-02772-x

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  • DOI: https://doi.org/10.1007/s10600-019-02772-x

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