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Synthesis and Antioxidant Activity of New Neomenthyl and Caranyl Thiotriazoles

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Chemistry of Natural Compounds Aims and scope

New neomenthyl and caranyl thiotriazoles were synthesized in up to 80% yields. Studies of the antioxidant and membrane-protective activity of the synthesized compounds in vitro showed that sulfides with a carane moiety were more active than analogs with a neomenthane substituent.

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Acknowledgment

The work was financially supported in part by the RFBR (Project 16-53-00171 Bel_a) and the UB, RAS, Molecular Biology Project (No. 18-3-3-17) and used equipment at the Khimiya Common Use Center (CUC), IC, KSC, UB, RAS and the CUC at the IB, KSC, UB, RAS. Animals from the scientific collection of experimental animals of the IB, KSC, UB, RAS were used in the work (http://www.ckp-rf.ru/usu/471933/).

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 48 Pervomaiskaya, Syktyvkar, 167000, Russia

    Yu. V. Gyrdymova, D. V. Sudarikov, S. A. Rubtsova, S. A. Patov & A. V. Kuchin

  2. Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya, Syktyvkar, 167982, Russia

    O. G. Shevchenko

  3. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 22 S. Kovalevskoi St., Ekaterinburg, 620137, Russia

    P. A. Slepukhin

  4. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 5/2 Akad. Kuprevicha St., Minsk, Republic of Belarus, 220141

    F. A. Lakhvich & F. S. Pashkovskii

Authors
  1. Yu. V. Gyrdymova
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  2. D. V. Sudarikov
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  3. O. G. Shevchenko
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  4. S. A. Rubtsova
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  5. P. A. Slepukhin
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  6. S. A. Patov
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  7. F. A. Lakhvich
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  8. F. S. Pashkovskii
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  9. A. V. Kuchin
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Corresponding author

Correspondence to D. V. Sudarikov.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2018, pp. 750–754.

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Gyrdymova, Y.V., Sudarikov, D.V., Shevchenko, O.G. et al. Synthesis and Antioxidant Activity of New Neomenthyl and Caranyl Thiotriazoles. Chem Nat Compd 54, 883–888 (2018). https://doi.org/10.1007/s10600-018-2504-y

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  • DOI: https://doi.org/10.1007/s10600-018-2504-y

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