Two new xanthones, atroxanthones A and B (1 and 2), together with four known xanthones (3–6), were isolated from the whole herb of Swertia atroviolacea. The structures of the metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 had weak activity with reductase inhibitions of 52.3 ± 2.5% and 42.9 ± 2.8%, respectively.
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Acknowledgment
This work was financially supported by the National Natural Science Foundation of China (Nos. 21262048 and 21562047) and the Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province (IRTSTYN 2014-11).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2017, pp. 895–897.
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Xing, Hh., Xiang, NJ., Liu, LX. et al. Two New Xanthones From Swertia atroviolacea and Their Anti-5α-Reductase Activity. Chem Nat Compd 53, 1052–1055 (2017). https://doi.org/10.1007/s10600-017-2199-5
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DOI: https://doi.org/10.1007/s10600-017-2199-5