Phytochemical isolation of the methanol extract of Macaranga rubiginosa leaves afforded five prenylated dihydrostilbenes. Two of them were known dihydrostilbenes laevifolins A (1) and B (2), while the other three were new compounds, trivially named macarubiginosins A–C (3–5). The structures of the new compounds were elucidated based on their UV, 1D and 2D NMR, and HR-ESI-MS spectral data. Compounds 1–5 were tested for their cytotoxicity against P-388 cells, showing that compound 1 was the most active with IC50 4.3 μM.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. K. M. Kulju, S. E. C. Sierra, S. G. A. Draisma, R. Samuel, and P. C. van Welzen, Am. J. Bot., 94, 1726 (2007).
J. W. F. Slik, P. J. A. Kebler, and P. C. van Welzen, Ecol. Indic., 2, 311 (2003).
D. Priatna, K. Kartawinata, and R. Abdulhadi, Reinwardtia, 12, 237 (2004).
J. J. Magadula, J. Med. Plant Res., 8, 489 (2014).
Y. M. Syah, E. H. Hakim, S. A. Achmad, M. Hanafi, and E. L. Ghisalberti, Nat. Prod. Commun., 4, 63 (2009).
M. Tanjung, E. H. Hakim, D. Mujahidin, and M. Hanafi, J. Asian Nat. Prod. Res., 11, 929 (2009).
W. Agustina, L. D. Juliawaty, E. H. Hakim, and Y. M. Syah, ITB J. Sci., 44A, 13 (2012).
Y. M. Syah and E. L. Ghisalberti, Nat. Prod. J., 2, 45 (2012).
M. S. Fareza, Y. M. Syah, D. Mujahidin, L. D. Juliawaty, and I. Kurniasih, Z. Naturforsch., 69c, 375 (2014).
N. Ahmat, I. M. Said, J. Latip, L. B. Din, Y. M. Syah, and E. H. Hakim, Nat. Prod. Commun., 2, 1137 (2007).
T. Ersam, S. A. Achmad, E. L. Ghisalberti, E. H. Hakim, and Y. M. Syah, J. Chem. Res. (S), 186 (2002).
V. Rukachaisirikul, M. Kamkaew, D. Sukavisit, S. Phongpaichit, P. Sawangchote, and W. C. Taylor, J. Nat. Prod., 66, 1531 (2003).
S. Sahidin, E. H. Hakim, L. D. Juliawaty, Y. M. Syah, L. B. Din, E. L. Ghisalberti, J. Latip, I. M. Said, and S. A. Achmad, Z. Naturforsch., 60c, 723 (2005).
Acknowledgment
Part of this work is supported by the KK Research Grant (Contract No. 1763/I1.B04.1/KU/2015), Bandung Institute of Technology. The authors also thank the staff of Herbarium Bogoriense, Center of Biological Research and Development, National Institute of Science, Bogor, Indonesia, for identification of the plant specimen.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2017, pp. 184–187.
Rights and permissions
About this article
Cite this article
Tanjung, M., Hakim, E.H. & Syah, Y.M. Prenylated Dihydrostilbenes from Macaranga rubiginosa . Chem Nat Compd 53, 215–218 (2017). https://doi.org/10.1007/s10600-017-1955-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-017-1955-x