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Secondary Metabolites of the Marine Fungus Penicillium chrysogenum

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Chemistry of Natural Compounds Aims and scope

A new benzoic acid, 2-(2-hydroxypropanamido) benzoic acid (1), along with three known compounds, cyclo-(Pro-Leu), cyclo-(4-hydroxyl-Pro-Phe), and (22E,24R)-ergosta-5,7,22-triene-3β-ol, were isolated from the fermentation broth of Penicillium chrysogenum. The structure of compound 1 was established by comprehensive analysis of the spectral data, especially 2D NMR spectra. Compound 1 showed remarkable anti-inflammatory and analgesic activities when administered at 100 mg/kg, but it exhibited no ulcerogenic effect.

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ACKNOWLEDGMENT

This work was partly funded by the National Innovation Drugs in Liaoning Province (Grant No. 2009ZX09301-012).

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Authors and Affiliations

  1. School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, Shenyang, People’s Republic of China

    Jingjing Wang, Yunli Zhao, Lei Men & Zhiguo Yu

  2. School of Life Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, Shenyang, People’s Republic of China

    Yixuan Zhang & Zheng Liu

  3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, Shenyang, People’s Republic of China

    Tiemin Sun & Yiding Geng

Authors
  1. Jingjing Wang
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  2. Yunli Zhao
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  3. Lei Men
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  4. Yixuan Zhang
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  5. Zheng Liu
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  6. Tiemin Sun
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  7. Yiding Geng
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  8. Zhiguo Yu
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Corresponding author

Correspondence to Zhiguo Yu.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2014, pp. 352–353.

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Wang, J., Zhao, Y., Men, L. et al. Secondary Metabolites of the Marine Fungus Penicillium chrysogenum . Chem Nat Compd 50, 405–407 (2014). https://doi.org/10.1007/s10600-014-0971-3

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  • DOI: https://doi.org/10.1007/s10600-014-0971-3

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