A library of sixty-five chalcones was prepared for screening against the protein phosphatase, cdc25B. From this library, thirteen compounds were found having good inhibitory activity. Two compounds have excellent activity and can be used for the design of more potent antiproliferative agents.
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Acknowledgment
The authors are thankful to The National Center for Drug Screening (Shanghai, China) for supplying data on the cdc25B inhibitory activity of the compounds. This work was supported by National Natural Science Foundation of China (20502034), Shanghai Leading Academic Discipline Project (No. B906), and Scientific and Technological Major Special Project – “Major Creation of New Drugs” of China (No. 2009ZX09102-043).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2013, pp. 181–187.
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Zhao, F., Zhao, QJ., Zhao, JX. et al. Synthesis and cdc25B inhibitory activity evaluation of chalcones. Chem Nat Compd 49, 206–214 (2013). https://doi.org/10.1007/s10600-013-0563-7
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DOI: https://doi.org/10.1007/s10600-013-0563-7