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Cell cycle regulation by the Cdc25 phosphatase family

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Activation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes activation during S-phase and plays a role in activating the mitotic kinase Cdkl/cyclin B in the cytoplasm. Active Cdkl/cyclin B then phosphorylates and activates Cdc25C leading to a positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human oncogenes. In addition, Cdc25 is a main player of the G2 arrest caused by DNA damage or in the presence of unreplicated DNA.

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References

  1. Morgan, D. (1995) Nature 374, 131–134.

    Article  PubMed  CAS  Google Scholar 

  2. Harper, J. (1997) Cancer Sury 29, 91–107.

    CAS  Google Scholar 

  3. Poon, R., Yamashita, K., Adamczewski, J., Hunt, T. and Shuttleworth, J. (1993) EMBO J. 12, 3123–3132.

    PubMed  CAS  Google Scholar 

  4. Solomon, M., Harper, J. and Shuttleworth, J. (1993) EMBO J. 12, 3133–3142.

    PubMed  CAS  Google Scholar 

  5. Russell, P. and Nurse, P. (1987) Cell 49, 559–567.

    Article  PubMed  CAS  Google Scholar 

  6. McGowan, C. H. and Russell, P. (1993) EMBO J. 12, 75–85.

    PubMed  CAS  Google Scholar 

  7. Mueller, P. R., Coleman, T., Kumagai, A. and Dunphy, W. (1995) Science 270, 86–90.

    Article  PubMed  CAS  Google Scholar 

  8. Liu, F., Stanton, J., Wu, Z. and Piwnica Worms, H. (1997) Mol. Cell. Biol. 17, 571–583.

    PubMed  CAS  Google Scholar 

  9. Millar, J, McGowan, C. H., Lenaers, G., Jones, R. and Russell, P. (1991) EMBO J. 10, 4301–4309.

    PubMed  CAS  Google Scholar 

  10. Gautier, J., Solomon, M. J., Booher, R. N., Bazan, J. F. and Kirschner, M. W. (1991) Cell 67, 197–211.

    Article  PubMed  CAS  Google Scholar 

  11. Dunphy, W. G. and Kumagai, A. (1991) Cell 67, 189–96.

    Article  PubMed  CAS  Google Scholar 

  12. Lee, M. S., Ogg, S., Xu, M., Parker, L., Donoghue, D., Mailer, J. and Piwnica-Worms, H. (1992) Mol. Biol. Cell 3, 73–84.

    PubMed  CAS  Google Scholar 

  13. Russell, P. and Nurse, P. (1986) Cell45, 145–53.

    Article  PubMed  CAS  Google Scholar 

  14. Sadhu, K., Reed, S. I., Richardson, H. and Russell, P. (1990) Proc. Natl. Acad. Sci. USA 87, 5139–5143.

    Article  PubMed  CAS  Google Scholar 

  15. Nagata, A., Igarashi, M., Jinno, S., Suto, K. and Okayama, H. (1991) New Biol. 3, 959–967.

    PubMed  CAS  Google Scholar 

  16. Galaktionov, K. and Beach, D. (1991) Cell 67, 1181–1194.

    Article  PubMed  CAS  Google Scholar 

  17. Hoffmann, I., Draetta, G. and Karsenti, E. (1994) EMBO J. 13, 4302–4310.

    PubMed  CAS  Google Scholar 

  18. Kumagai, A. and Dunphy, W. (1991) Cell 64, 903–914.

    Article  PubMed  CAS  Google Scholar 

  19. Millar, J. B. A., Blevitt, J., Gerace, L., Sadhu, K., Featherstone, C. and Russell, P. (1991) Proc. Natl. Acad. Sci. USA 88, 10500–10504.

    Article  PubMed  CAS  Google Scholar 

  20. Gabrielli, B., C., D. S., Tonks, I., Clark, J., Hayward, N. and Ellem, K. (1996) J. Cell. Sci. 109, 1081–1093.

    PubMed  CAS  Google Scholar 

  21. Lammer, C., Wagerer, S., Saffrich, R., Mertens, D., Ansorge, W. and Hoffmann, I. (1998) J. Cell Sci. 111, 2445–2453.

    PubMed  CAS  Google Scholar 

  22. Kumagai, A. and Dunphy, W. G. (1992) Cell 70, 139–151.

    Article  PubMed  CAS  Google Scholar 

  23. Hoffmann, I., Clarke, P. R., Marcote, M., J., Karsenti, E. and Draetta., G. (1993) EMBO J. 12, 53–63.

    PubMed  CAS  Google Scholar 

  24. Clarke, P., Hoffmann, I., Draetta, G. and Karsenti, E. (1993) Mol. Biol. Cell 4, 397–411.

    PubMed  CAS  Google Scholar 

  25. Heald, R. and McKeon, F. (1990) Cell 61, 579–589.

    Article  PubMed  CAS  Google Scholar 

  26. Peter, M., Nakagawa, J., Dorée, M., Labbé, J. C. and Nigg, E. A. (1990) Cell 61, 591–602.

    Article  PubMed  CAS  Google Scholar 

  27. Schmid, F. (1995) Curr Biol. 5, 993–994.

    Article  PubMed  CAS  Google Scholar 

  28. Crenshaw, D., Yang, J., Means, A. and Kornbluth, S. (1998) EMBO J. 17, 1315–1327.

    Article  PubMed  CAS  Google Scholar 

  29. Shen, M., Stukenberg, P., Kirschner, M. and Lu, P. (1998) Genes Dev. 12, 706–720.

    Article  PubMed  CAS  Google Scholar 

  30. Yaffe, M., Schutkowski, M., Shen, M., Zhou, X., Stukenberg, P., Rahfeld, J., Xu, J., Kuang, J., Kirschner, M., Fischer, G., Catley, L. and Lu, K. (1997) Science 278, 1957–1960.

    Article  PubMed  CAS  Google Scholar 

  31. Kumagai, A. and Dunphy, W. G. (1996) Science 273, 1377–1380.

    Article  PubMed  CAS  Google Scholar 

  32. Lane, H. and Nigg, E. (1997) TIBS 7, 63–68.

    CAS  Google Scholar 

  33. Abrieu, A., Brassac, T., Galas, S., Fisher, D., Labbé, J.-C. and Doreé, M. (1998) J. Cell Sci. 111, 1751–1757.

    PubMed  CAS  Google Scholar 

  34. Goldsteyn, R., Mundt, K., Fry, A. and Nigg, E. (1995) J. Cell Biol. 129, 1617–1628.

    Article  Google Scholar 

  35. Lane, H. and Nigg, E. (1996) J. Cell Biol. 135, 1701–1713.

    Article  PubMed  CAS  Google Scholar 

  36. Li, B., Ouyang, B., Pan, H., Reissmann, Slamon, D., Arceci, R., Lu, L. and Dai, W. (1996) J. Biol. Chem. 271, 19402–19408.

    Article  PubMed  CAS  Google Scholar 

  37. Ouyang, B., Pan, H., Lu, L., Li, J., Stambrook, P. and Dai, W. (1997) J. Biol. Chem. 272, 28646–28651.

    Article  PubMed  CAS  Google Scholar 

  38. Baldin, V., Cans, C., Superti-Furga, G. and Ducommun, B. (1997) Oncogene 14, 2485–2495.

    Article  PubMed  CAS  Google Scholar 

  39. Nishijima, H., Nishitani, H., Seki, T. and Nishimototo, T. (1997) J. Cell. Biol. 138, 1105–1116.

    Article  PubMed  CAS  Google Scholar 

  40. Baldin, V., Cans, C., Knibiehler, M. and Ducommun, B. (1997) J. Biol. Chem. 272, 32731–32734.

    Article  PubMed  CAS  Google Scholar 

  41. Pines, J. and Hunter, T. (1991) J. Cell Biol. 115, 1–17.

    Article  PubMed  CAS  Google Scholar 

  42. Gu, Y., Rosenblatt, J. and Morgan, D. O. (1992) EMBO J. 11, 3995–4005.

    PubMed  CAS  Google Scholar 

  43. Jinno, S., Suto, K., Nagata, A., Igarashi, M., Kanaoka, Y., Nojima, H. and Okayama, H. (1994) EMBO J. 13, 1549–1556.

    PubMed  CAS  Google Scholar 

  44. Tereda, Y., Tatsuka, M., Jinno, S. and Okayama, H. (1995) Nature 376, 358–362.

    Article  Google Scholar 

  45. Iavarone, A. and Massague, J. (1997) Nature 387, 417–422.

    Article  PubMed  CAS  Google Scholar 

  46. Jinno, S., Hung, S. and Okayama, H. (1999) Oncogene 18, 565–571.

    Article  PubMed  CAS  Google Scholar 

  47. Coqueret, O., Bérubé, G. and Nepveu, A. (1998) EMBO J. 17, 4680–4694.

    Article  PubMed  CAS  Google Scholar 

  48. Tiefenbrun, N., Melamed, D., Levy, N., Resnitzky, D., Hoffmann, I., Reed, S. and Kimchi, A. (1996) Mol. Cell. Biol. 16, 3934–3944.

    PubMed  CAS  Google Scholar 

  49. Reynisdottir, R., Polyak, K., Iavarone, A. and Massagué, A. (1995) Genes Dev. 9, 1831–1845.

    Article  PubMed  CAS  Google Scholar 

  50. Galaktionov, K. and Beach, D. (1996) Nature 382, 511–517.

    Article  PubMed  CAS  Google Scholar 

  51. Berns, K., Hijmans, E. and Bernards, R. (1997) Oncogene 15, 1347–1356.

    Article  PubMed  CAS  Google Scholar 

  52. Vlach, J., Hennecke, S., Alevizopoulos, K., Conti, D. and Amati, B. (1996) EMBO J. 15, 6595–6604.

    PubMed  CAS  Google Scholar 

  53. Saha, P., Eichbaum, Q., Silberman, E., Mayer, B. and Dutta, A. (1997) Mol. Cell Biol. 17, 4338–4345.

    PubMed  CAS  Google Scholar 

  54. Rhind, N., Furnari, B. and Russell, P. (1997) Genes Dev. 11, 504–511.

    Article  PubMed  CAS  Google Scholar 

  55. Walworth, N., Davey, S. and Beach, D. (1993) Nature 363, 368–371.

    Article  PubMed  CAS  Google Scholar 

  56. Walworth, N. and Bernards, R. (1996) Science 271, 353–356.

    Article  PubMed  CAS  Google Scholar 

  57. Funari, B., Rhind, N. and Russell, P. (1997) Science 277, 1495–1497.

    Article  Google Scholar 

  58. Sanchez, Y., Wong, C., Thoma, R., Richman, R., Wu, Z., Piwnica-Worms, H. and Elledge, S. (1997) Science 277, 1497–1501.

    Article  PubMed  CAS  Google Scholar 

  59. Peng, C., Graves, P., Thoma, R., Wu, R., Shaw, A. and Piwnica-Worms, H. (1997) Science 277, 1501–1505.

    Article  PubMed  CAS  Google Scholar 

  60. Boddy, M., Funrai, B., Mondesert, O. and Russell, P. (1998) Science 280, 909–912.

    Article  PubMed  CAS  Google Scholar 

  61. Kumagai, A., Guo, Z., Emami, K., Wang, S. and Dunphy, W. (1998) J. Cell Biol. 142, 1559–1569.

    Article  PubMed  CAS  Google Scholar 

  62. Blasina, A., Van de Weyer, I., Laus, M., Luyten, W., A., P. and McGowan, C. (1999) Curr. Biol. 9, 1–10.

    Article  PubMed  CAS  Google Scholar 

  63. Lopez-Girona, A., Funari, B., Mondesert, O. and Russell, P. (1999) Nature 397, 172–175.

    Article  PubMed  CAS  Google Scholar 

  64. Rhind, N. and Russell, P. (1998) Mol. Cell Biol. 18, 3782–3787.

    PubMed  CAS  Google Scholar 

  65. Lindsay, H., Griffiths, D., Edwards, R., Christensen, P., Murray, J., Osman, F., Walworth, N. and Carr, A. (1998) Genes Dev. 12, 382–395.

    Article  PubMed  CAS  Google Scholar 

  66. Matsuoka, S., Huang, M. and Elledge, S. (1998) Science 282, 1893–1896.

    Article  PubMed  CAS  Google Scholar 

  67. Fauman, E., Cogswell, J., Lovejoy, B., Rocque, W., Holmes, W., Montana, V., PiwnicaWorms, H., Rink, M. and Saper, M. (1998) Cell 93, 617–625.

    Article  PubMed  CAS  Google Scholar 

  68. Xu, X. and Burke, S. (1996) J. Bol. Chem. 271, 5118–5124.

    Article  CAS  Google Scholar 

  69. Izumi, T., Walker, D. and Mailer, J. (1992) Mol. Biol. Cell 3, 927–939.

    PubMed  CAS  Google Scholar 

  70. Izumi, T. and Mailer, J. (1993) Mol. Biol. Cell 4, 1337–1350.

    PubMed  CAS  Google Scholar 

  71. Galaktionov, K., Lee, A., Eckstein, J., Draetta, G., Meckler, J., Loda, M. and Beach, D. (1995) Science 269, 1575–1577.

    Article  PubMed  CAS  Google Scholar 

  72. Wu, W., Fan, Y., Kemp, B., Walsh, G. and Mao, L. (1998) Cancer Res. 58, 4082–4085.

    PubMed  CAS  Google Scholar 

  73. Hernandez, S., Hernandez, I., Bea, S., Cazorla, M., Fernandez, P., Nadal, A., Muntane, J., Mallofre, C., Montserrat, E., Cardesa, A. and Campo, E. (1998) Cancer Res. 58, 1762–1767.

    PubMed  CAS  Google Scholar 

  74. Gasparotto, D., Maestro, R., Piccinin, S., Vukosavljevic, T., Barzan, L., Sulfaro, S. and Boiocchi, M. (1997) Cancer Res. 57, 2366–2368.

    PubMed  CAS  Google Scholar 

  75. Demetrick, D. and Beach, D. (1993) Genomics 18, 144–147.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. Applied Tumor Virology (F0400), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D-69120, Heidelberg, Germany

    Ida Nilsson & Ingrid Hoffmann

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  1. Ida Nilsson
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  2. Ingrid Hoffmann
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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Nilsson, I., Hoffmann, I. (2000). Cell cycle regulation by the Cdc25 phosphatase family. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_10

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  • DOI: https://doi.org/10.1007/978-1-4615-4253-7_10

  • Publisher Name: Springer, Boston, MA

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