A new lignan glycoside, 9-acetyl lanicepside B (1), was isolated from the whole plant of Boschniakia himalaica, along with five known compounds, lanicepside A (2), plantainoside D (3), plantamajoside (4), (–)-woonenoside XI (5), and syringin (6). The new compound's structure was established on the basis of detailed 1D and 2D NMR spectroscopic analysis and chemical evidence. 9-Acetyl lanicepside B (1) showed weak in vitro cytotoxic activities against A549 and P388 with IC50 values of 64.7 μM and 72.5 μM, respectively. Syringin (6) showed moderate in vitro cytotoxic activities against A549 and HL-60 with IC50 values of 32.5 μM and 41.8 μM, respectively.
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Acknowledgment
The work was financially supported by the Talented Faculty Foundation of South-Central University for Nationalities (YZ211002 to X. Z. Yang).
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2012, pp. 502–504.
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Yang, X., Yuan, J. & Wan, J. Cytotoxic phenolic glycosides from Boschniakia himalaica . Chem Nat Compd 48, 555–558 (2012). https://doi.org/10.1007/s10600-012-0308-z
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DOI: https://doi.org/10.1007/s10600-012-0308-z