Skip to main content
Log in

A New Benzophenone and Bioactive Constituents of Hypericum nokoense

  • Published:
Chemistry of Natural Compounds Aims and scope

A new benzophenone derivative, hyperinokone (1), has been isolated from the aerial part of Hypericum nokoense, together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (4), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (5), and eleocharin A (6) exhibited cytotoxicities, with IC50 values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds 4 and 6 exhibited cytotoxicities, with IC50 values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition, 3, 4, and 6 showed potent inhibition with IC50 values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. K. B. Robson, Guttiferae in Flora of Taiwan, Vol. 2, 2nd Ed., Editorial Committee of the Flora of Taiwan, Taipei, Taiwan, 1996, pp. 694–714.

    Google Scholar 

  2. C. Y. Huang, T. C. Chang, Y. J. Wu, Y. Chen, and J. J. Chen, Molecules, 25, 4463 (2020).

    Article  CAS  Google Scholar 

  3. D. Hong, F. Yin, L. H. Hu, and P. Lu, Phytochemistry, 65, 2595 (2004).

    Article  CAS  Google Scholar 

  4. Z. Y. Xiao, Y. H. Zeng, Q. Mu, W. K. P. Shiu, and S. Gibbons, Chem. Biodiv., 7, 953 (2010).

    Article  CAS  Google Scholar 

  5. Q. Chen, L. Di, Y. Zhang, and N. Li, J. Ethnopharmacol., 259, 112948 (2020).

    Article  CAS  Google Scholar 

  6. H. Zhu, Ch. Chen, J. Yang, X. N. Li, J. Liu, B. Sun, Sh. X. Huang, D. Li, G. Yao, Z. Luo, Y. Li, J. Zhang, Y. Xue, and Y. Zhang, Org. Lett., 16, 6322 (2014).

    Article  CAS  Google Scholar 

  7. K. Zhou, C. Wunsch, J. Dai, and S.-M. Li, Org. Lett., 19, 388 (2017).

    Article  CAS  Google Scholar 

  8. T. T. Dao, T. T. Dang, P. H. Nguyen, E. Kim, P. T. Thuong, and W. K. Oh, Bioorg. Med. Chem. Lett., 22, 3688 (2012).

    Article  CAS  Google Scholar 

  9. K. Ishiguro, S. Nagata, H. Fukumoto, M. Yamaki, K. Isoi, and Y. Oyama, Phytochemistry, 32, 1583 (1993).

    Article  CAS  Google Scholar 

  10. R. Borges-Argaez, L. M. Pena-Rodriguez, and P. G. Waterman, Phytochemistry, 60, 533 (2002).

    Article  CAS  Google Scholar 

  11. Y. Luo, X. Li, J. He, J. Su, L. Peng, X. Wu, R. Du, and Q. Zhao, Food Chem., 164, 30 (2014).

    Article  CAS  Google Scholar 

  12. C. M. Huang, P. J. Sung, Y. H. Kuo, T. H. Chang, C. L. Chen, M. J. Cheng, and J. J. Chen, Chem. Nat. Compd., 56, 440 (2020).

    Article  CAS  Google Scholar 

  13. T. Mosmann, J. Immunol. Methods, 65, 55 (1983).

    Article  CAS  Google Scholar 

  14. M. Johansson, B. Kopcke, H. Anke, and O. Sterner, J. Antibiot., 55, 104 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This research was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B- 010-029-MY3 and MOST 106-2320-B-010-033-MY3), awarded to Prof. J.-J. Chen. This work was also supported by Grants from Far Eastern Memorial Hospital–National Yang-Ming University Joint Research Program (109DN19), Medical Research Fund (KAFGH-D-109039) of Kaohsiung Armed Forces General Hospital, and Yuan′s General Hospital (YGH 20-006). We gratefully thank Ms. Shou-Ling Huang and Dr. Iren Wang for assistance in NMR experiments of the Instrumentation Center at NTU which is supported by the Ministry of Science and Technology, Taiwan. Fu-Sen Wu, Ching-Ju Hung, and Chien-Liang Lin have contributed equally to this manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2021, pp. 552–555.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, FS., Hung, CJ., Lin, CL. et al. A New Benzophenone and Bioactive Constituents of Hypericum nokoense. Chem Nat Compd 57, 645–649 (2021). https://doi.org/10.1007/s10600-021-03441-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-021-03441-8

Keywords

Navigation