A new benzophenone derivative, hyperinokone (1), has been isolated from the aerial part of Hypericum nokoense, together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (4), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (5), and eleocharin A (6) exhibited cytotoxicities, with IC50 values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds 4 and 6 exhibited cytotoxicities, with IC50 values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition, 3, 4, and 6 showed potent inhibition with IC50 values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.
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Acknowledgment
This research was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B- 010-029-MY3 and MOST 106-2320-B-010-033-MY3), awarded to Prof. J.-J. Chen. This work was also supported by Grants from Far Eastern Memorial Hospital–National Yang-Ming University Joint Research Program (109DN19), Medical Research Fund (KAFGH-D-109039) of Kaohsiung Armed Forces General Hospital, and Yuan′s General Hospital (YGH 20-006). We gratefully thank Ms. Shou-Ling Huang and Dr. Iren Wang for assistance in NMR experiments of the Instrumentation Center at NTU which is supported by the Ministry of Science and Technology, Taiwan. Fu-Sen Wu, Ching-Ju Hung, and Chien-Liang Lin have contributed equally to this manuscript.
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2021, pp. 552–555.
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Wu, FS., Hung, CJ., Lin, CL. et al. A New Benzophenone and Bioactive Constituents of Hypericum nokoense. Chem Nat Compd 57, 645–649 (2021). https://doi.org/10.1007/s10600-021-03441-8
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DOI: https://doi.org/10.1007/s10600-021-03441-8