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Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi

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Chemistry of Natural Compounds Aims and scope

A new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a common compound, ergosterol (3), were isolated from the mixed cultured mycelia of two marine-derived mangrove epiphytic Aspergillus sp. fungi. Extensive application of 1D and 2D NMR techniques was made to characterize the structure and to establish the 1H and 13 C assignments of compound 1. In the antibacterial assays, both compounds 1 and 2 showed significant antibacterial activity against some selected Gram bacteria.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Foshan University, 528000, Foshan, P. R. China

    Feng Zhu, Xin Chen & Meizhen Huang

  2. Hainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry, School of Chemistry & Chemical Engineering, Hainan Normal University, Haikou, 571158, P. R. China

    Guangying Chen

  3. School of Medical Science, Foshan University, 528000, Foshan, P. R. China

    Xueqin Wan

Authors
  1. Feng Zhu
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  2. Guangying Chen
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  3. Xin Chen
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  4. Meizhen Huang
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  5. Xueqin Wan
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Correspondence to Feng Zhu.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 674–676, September–October, 2011.

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Zhu, F., Chen, G., Chen, X. et al. Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi. Chem Nat Compd 47, 767–769 (2011). https://doi.org/10.1007/s10600-011-0053-8

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  • DOI: https://doi.org/10.1007/s10600-011-0053-8

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