We report a new, single-stage method for the synthesis of 2-arylpyrrolidines, based on an acid-catalyzed reaction of 2-naphthol with γ-ureidoacetals, enabling the preparation of the target compounds under mild conditions, while avoiding costly reagents and catalysts.
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The work was performed with financial support from the Russian Foundation for Basic Research (projects 14-03-00191-а and 14-03-31740 mol_a)
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 769-776, May, 2014.
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Gazizov, A.S., Smolobochkin, A.V., Burilov, A.R. et al. Interaction of 2-Naphthol with γ-Ureidoacetals. A New Method for the Synthesis of 2-Arylpyrrolidines. Chem Heterocycl Comp 50, 707–714 (2014). https://doi.org/10.1007/s10593-014-1524-1
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DOI: https://doi.org/10.1007/s10593-014-1524-1