We have developed a method for the synthesis of dimethyl 7-aryl-8-(3-arylquinoxalin-2-yl)-2-(R-imino)-9-oxo-1,6-dioxaspiro[4.4]nona-3,7-diene-3,4-dicarboxylates, based on a three-component reaction of 5-aryl-4-(quinoxalin-2-yl)furan-2,3-diones, 1-adamantylisocyanide or о-methylphenylisocyanide, and dimethyl acetylenedicarboxylate.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 5-10, 2014.
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Lisovenko, N.Y., Dryahlov, A.V. Three-Component Synthesis of Dimethyl 7-Aryl-8-(3-Arylquinoxalin-2-yl)-2-(R-Imino)-9-Oxo-1,6-Dioxa-Spiro[4.4]Nona-3,7-Diene-3,4-Dicarboxylates. Chem Heterocycl Comp 50, 1–6 (2014). https://doi.org/10.1007/s10593-014-1439-x
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DOI: https://doi.org/10.1007/s10593-014-1439-x
Keywords
- 5-aryl-4-(quinoxalin-2-yl)furan-2,3-diones
- dimethyl acetylenedicarboxylate
- dimethyl 7-aryl-8-(3-arylquinoxalin-2-yl)-2-(R-imino)-9-oxo-1,6-dioxaspiro[4.4]nona-3,7-diene-3,4-dicarboxylates
- isocyanides
- methyl 2-[5-aryl-4-(quinoxalin-2-yl)-3-oxo-2(3H)-furanylidene]acetate
- γ-spiroiminolactones
- multicomponent reaction