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Multicomponent synthesis of 3-(alkylsulfanyl)-8-aryl(hetaryl)-7-acetyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles

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Abstract

Multicomponent condensation of 3-aryl(hetaryl)-2,4-diacetyl-5-hydroxy-5-methylcyclohexanones with 2-cyanoethanethioamide and alkylating agents in the presence of morpholine afforded 3-(alkylsulfanyl)-8-aryl(hetaryl)-7-acetyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles, 1-[1-amino-6-aryl(hetaryl)-8-hydroxy-6,7,8,9-tetrahydrothieno[2,3-c]isoquinolin-7-yl]ethanones, and 3,3′-[ethane-1,2-diylbis( sulfanediyl)]bis[7-acetyl-6-hydroxy-1,6-dimethyl-8-(furan-2-yl)-5,6,7,8-tetrahydroisoquinolin-4-carbonitrile].

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Authors and Affiliations

  1. Taras Shevchenko Lugansk National University, ul. Oboronnaya 2, Lugansk, 91011, Ukraine

    S. M. Sukach & V. D. Dyachenko

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  1. S. M. Sukach
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  2. V. D. Dyachenko
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Correspondence to S. M. Sukach.

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Original Russian Text © S.M. Sukach, V.D. Dyachenko, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 7, pp. 1037–1042.

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Sukach, S.M., Dyachenko, V.D. Multicomponent synthesis of 3-(alkylsulfanyl)-8-aryl(hetaryl)-7-acetyl-6-hydroxy-1,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles. Russ J Org Chem 51, 1020–1025 (2015). https://doi.org/10.1134/S1070428015070210

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  • DOI: https://doi.org/10.1134/S1070428015070210

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