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One-pot, Three-component Synthesis of [1,3]thiazolo[4,3-b][1,3,4]thiadiazoles: Correct Structure of the Products

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Chemistry of Heterocyclic Compounds Aims and scope

The products of the one-pot, three-component synthesis of [1,3]thiazolo-[4,3-b][1, 3, 4]thiadiazoles from aromatic aldehydes, thioglycolic acid, and compounds containing a C(=S)–N–NH2 fragment (thiosemicarbazide or 4-amino-2,4-dihydro-3H-1,2,4-triazole-3-thiones) are not condensed hetero-cycles (as reported by several researchers), but are thiosemicarbazones or triazolylimines of the aldehydes used.

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Notes

  1. Here and further, for the AA'XX' system of the para-substituted phenyl ring, instead of the true 3 J AX values, the distances between maxima of the corresponding doublet-like multiplets are indicated.

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Authors and Affiliations

  1. Saint Petersburg State University, 26 Universitetsky Ave., Saint Petersburg, 198504, Russia

    M. A. Kuznetsov

  2. Federal State Institution for Science “Toxicology Institute”, Federal Medical-Biological Agency of Russia, 1 Bekhterev St., Saint Petersburg, 192019, Russia

    A. Ya. Bespalov

Authors
  1. M. A. Kuznetsov
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  2. A. Ya. Bespalov
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Correspondence to M. A. Kuznetsov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1572-1577, October, 2013.

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Kuznetsov, M.A., Bespalov, A.Y. One-pot, Three-component Synthesis of [1,3]thiazolo[4,3-b][1,3,4]thiadiazoles: Correct Structure of the Products. Chem Heterocycl Comp 49, 1458–1463 (2014). https://doi.org/10.1007/s10593-014-1396-4

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