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One pot, multi-component synthesis of 3-[4-aryl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one

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Abstract

A series of 3-[-4-phenyl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one(4a–4g) and 3-{[4-(2-oxo-2H-chromen-3-yl)-thiazol-2-yl]-hydrazono}-1,3-dihydro-indol-2-one(6a–6d) has been prepared in a one-step procedure from condensation reaction of isatin(1), thiosemicarbazide(2) and bromoacetophenones(3)/or 3-(2-bromoacetyl)coumarins(4). The method provides a simple and efficient route to prepare the compounds in good yields and in a short experimental time as compared to its stepwise procedure.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology, Warangal, 506 004, A. P., India

    Tewodros Birhanu Aychiluhim & Rajeswar Rao Vedula

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  1. Tewodros Birhanu Aychiluhim
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  2. Rajeswar Rao Vedula
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Correspondence to Rajeswar Rao Vedula.

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Aychiluhim, T.B., Vedula, R.R. One pot, multi-component synthesis of 3-[4-aryl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one. Chem. Res. Chin. Univ. 30, 601–604 (2014). https://doi.org/10.1007/s40242-014-4036-8

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  • DOI: https://doi.org/10.1007/s40242-014-4036-8

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