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New methodology for functionalization of the imidazole ring by alkynes

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Chemistry of Heterocyclic Compounds Aims and scope

A new methodology for functionalization of the imidazole ring via the zwitterionic intermediates and their carbene tautomers generated by nucleophilic addition of 1-substituted imidazoles to electron-deficient acetylenes followed by reactions with the appropriate electrophiles is discussed.

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This work was supported by the Russian Foundation for Fundamental Investigatioons (grant No. 11-03-00203), Presidium of Department of Chemical Sciences and Materials RAS (grant No. 5.1.3.), and the Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants (grant NSh-3230.2010.3).

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Authors and Affiliations

  1. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of Russian Academy of Sciences, 1 Favorsky St., Irkutsk, 664033, Russia

    B. A. Trofimov, L. V. Andriyankova & K. V. Belyaeva

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  1. B. A. Trofimov
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  2. L. V. Andriyankova
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  3. K. V. Belyaeva
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Correspondence to B. A. Trofimov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 153-160, January, 2012.

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Trofimov, B.A., Andriyankova, L.V. & Belyaeva, K.V. New methodology for functionalization of the imidazole ring by alkynes. Chem Heterocycl Comp 48, 147–154 (2012). https://doi.org/10.1007/s10593-012-0978-2

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  • DOI: https://doi.org/10.1007/s10593-012-0978-2

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