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Development of the catalytic synthesis of compounds of the quinoline series (the N. S. Kozlov reaction) (Review)*

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Chemistry of Heterocyclic Compounds Aims and scope

This article is dedicated to the 80th anniversary of the Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus (in 1929-1959 the Institute of Chemistry, Academy of Sciences of the BSSR). It contains a review of the advances in the synthesis and properties of condensed heterocyclic systems containing a quinoline fragment – derivatives of quinaldine, benzo[f]quinoline, indeno- and indoloquinoline, benzo[a]phenanthridine, benzoacridine, tetrahydroquinoline, 1,7- and 4,7-phen-anthroline. The reactions forming the basis of the synthesis of the heterocycles are described – catalytic reaction of amines with acetylene, catalytic condensation of azomethines with methyl and α-methylene ketones, triple-component condensation of arylamines, carbonyl compounds, and CH acids.

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Authors and Affiliations

  1. Institute of Physical Organic Chemistry, Academy of Sciences of Belarus, Minsk, 220072, Belarus

    N. G. Kozlov, K. N. Gusak & A. P. Kadutskii

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  1. N. G. Kozlov
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  2. K. N. Gusak
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  3. A. P. Kadutskii
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Correspondence to N. G. Kozlov.

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Dedicated to the 80th Anniversary of the Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 643-672, May, 2010.

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Kozlov, N.G., Gusak, K.N. & Kadutskii, A.P. Development of the catalytic synthesis of compounds of the quinoline series (the N. S. Kozlov reaction) (Review)*. Chem Heterocycl Comp 46, 505–528 (2010). https://doi.org/10.1007/s10593-010-0540-z

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