Depending on the substituents in the aryl moiety, the fusion of N-aryl-N-ethoxycarbonyl-β-alanines with thiocarbohydrazide gives di- or monotriazole derivatives, namely, 4-amino-(2-{[2-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]anilino}ethyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones, 1-[2-(4-amino- 5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]-2,3-dihydroquinolin-4(1H)-ones, 4-amino-3-[2-(4-methylanilino))ethyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione and 4-amino-3-[2-(4-ethoxyanilino)-ethyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione. A ditriazolethione derivative was also obtained from the diethyl ester of N-ethoxycarbonyl-N-(4-ethoxyphenyl)- β-alanine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. Tumosene and Z. I. Bersnevičius, Khim. Geterotsikl. Soedin., 1353 (2007) [Chem. Heterocycl. Comp., 43, 1148 (2007)].
G. Mekuskiene, S. Tumkevičius, and P. Vainilavičius, J. Chem. Res. (S), 213 (2002).
G. Mekuskiene, and P. Vainilavičius, Khim. Geterotsikl. Soedin., 1088 (2007). [Chem. Heterocycl. Comp., 43, 919 (2007)].
K. Kantminene, Dis. Doc. Chem. Sci., Kaunas (1998).
N. Demirbas, A. Demirbas, S. A. Karaoglu, and E. Êelik, ARKIVOC, (i), 75 (2005).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1564-1567, October, 2009.
Rights and permissions
About this article
Cite this article
Tumosienė, I., Beresnevičius, Z.J. Preparation of aminotriazole-thione derivatives from n-aryl-n-carboxyethyl-β-alanines. Chem Heterocycl Comp 45, 1257–1260 (2009). https://doi.org/10.1007/s10593-010-0416-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10593-010-0416-2