Abstract
Myopia is a refractive disorder arising from a mismatch between refractive power and relatively long axial length of the eye. With its dramatically increasing prevalence, myopia has become a pervasive social problem. It is commonly accepted that abnormal visual input acts as an initiating factor of myopia. As the first station to perceive visual signals, the retina plays an important role in myopia etiology. The retina is a fine-layered structure with multitudinous cells, processing intricate visual signals via numerous molecular pathways. Accordingly, dopaminergic mechanisms, contributions of rod and cone photoreceptors, myopic structural changes of retinal pigment epithelium (RPE) and neuro-retinal layers have all suggested a vital role of retinal dysfunction in myopia development. Herein, we separately discuss myopia-related retinal dysfunction and current dilemmas by different levels, from molecules to cells, with the hope that the comprehensive delineation could contribute to a better understanding of myopia etiology, indicate novel therapeutic targets, and inspire future studies.
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References
Aleman AC, Wang M, Schaeffel F (2018) Reading and myopia: contrast polarity matters. Sci Rep 8(1):10840. https://doi.org/10.1038/s41598-018-28904-x
Anera RG, Soler M, de la Cruz CJ, Salas C, Ortiz C (2009) Prevalence of refractive errors in school-age children in Morocco. Clin Exp Ophthalmol 37(2):191–196. https://doi.org/10.1111/j.1442-9071.2009.02001.x
Arno G, Hull S, Robson AG, Holder GE, Cheetham ME, Webster AR, Plagnol V, Moore AT (2015) Lack of interphotoreceptor retinoid binding protein caused by homozygous mutation of RBP3 is associated with high myopia and retinal dystrophy. Invest Ophthalmol vis Sci 56(4):2358–2365. https://doi.org/10.1167/iovs.15-16520
Ashby RS, Schaeffel F (2010) The effect of bright light on lens compensation in chicks. Invest Ophthalmol vis Sci 51(10):5247–5253. https://doi.org/10.1167/iovs.09-4689
Ashby R, McCarthy CS, Maleszka R, Megaw P, Morgan IG (2007) A muscarinic cholinergic antagonist and a dopamine agonist rapidly increase ZENK mRNA expression in the form-deprived chicken retina. Exp Eye Res 85(1):15–22. https://doi.org/10.1016/j.exer.2007.02.019
Ashby R, Kozulin P, Megaw PL, Morgan IG (2010) Alterations in ZENK and glucagon RNA transcript expression during increased ocular growth in chickens. Mol vis 16:639–649
Ashby RS, Zeng G, Leotta AJ, Tse DY, McFadden SA (2014) Egr-1 mRNA expression is a marker for the direction of mammalian ocular growth. Invest Ophthalmol vis Sci 55(9):5911–5921. https://doi.org/10.1167/iovs.13-11708
Aslam B, Basit M, Nisar MA, Khurshid M, Rasool MH (2017) Proteomics: technologies and their applications. J Chromatogr Sci 55(2):182–196. https://doi.org/10.1093/chromsci/bmw167
Atkinson CL, Feng J, Zhang DQ (2013) Functional integrity and modification of retinal dopaminergic neurons in the rd1 mutant mouse: roles of melanopsin and GABA. J Neurophysiol 109(6):1589–1599. https://doi.org/10.1152/jn.00786.2012
Baba H, Kohno T, Okamoto M, Goldstein PA, Shimoji K, Yoshimura M (1998) Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn. J Physiol 508:83–93. https://doi.org/10.1111/j.1469-7793.1998.083br.x
Baba K, DeBruyne JP, Tosini G (2017) Dopamine 2 receptor activation entrains circadian clocks in mouse retinal pigment epithelium. Sci Rep 7(1):5103. https://doi.org/10.1038/s41598-017-05394-x
Baba K, Goyal V, Tosini G (2022) Circadian regulation of retinal pigment epithelium function. Int J Mol Sci. https://doi.org/10.3390/ijms23052699
Banerjee S, Wang Q, Zhao F, Tang G, So C, Tse D, To CH, Feng Y, Zhou X, Pan F (2020) Increased connexin36 phosphorylation in aii amacrine cell coupling of the mouse myopic retina. Front Cell Neurosci 14:124. https://doi.org/10.3389/fncel.2020.00124
Banerjee S, Wang Q, Tang G, So C, Shan SW, Li KK, Do CW, Pan F (2021) Functional connexin35 increased in the myopic chicken retina. Vis Neurosci. https://doi.org/10.1017/s0952523821000079
Bao XY, Cao J (2019) MiRNA-138–5p protects the early diabetic retinopathy by regulating NOVA1. Eur Rev Med Pharmacol Sci 23(18):7749–7756
Barathi VA, Chaurasia SS, Poidinger M, Koh SK, Tian D, Ho C, Iuvone PM, Beuerman RW, Zhou L (2014) Involvement of GABA transporters in atropine-treated myopic retina as revealed by iTRAQ quantitative proteomics. J Proteome Res 13(11):4647–4658. https://doi.org/10.1021/pr500558y
Berber P, Grassmann F, Kiel C, Weber BH (2017) An eye on age-related macular degeneration: the role of MicroRNAs in disease pathology. Mol Diagn Ther 21(1):31–43. https://doi.org/10.1007/s40291-016-0234-z
Bertrand E, Fritsch C, Diether S, Lambrou G, Müller D, Schaeffel F, Schindler P, Schmid KL, van Oostrum J, Voshol H (2006) Identification of apolipoprotein A-I as a “STOP” signal for myopia. Mol Cell Proteomics 5(11):2158–2166. https://doi.org/10.1074/mcp.M600073-MCP200
Bitzer M, Schaeffel F (2002) Defocus-induced changes in ZENK expression in the chicken retina. Invest Ophthalmol vis Sci 43(1):246–252
Boatright JH, Rubim NM, Iuvone PM (1994) Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. Vis Neurosci 11(5):1003–1012. https://doi.org/10.1017/s095252380000393x
Brown DM, Mazade R, Clarkson-Townsend D, Hogan K, Datta Roy PM, Pardue MT (2022) Candidate pathways for retina to scleral signaling in refractive eye growth. Exp Eye Res 219:109071. https://doi.org/10.1016/j.exer.2022.109071
Bueno JM, Palacios R, Giakoumaki A, Gualda EJ, Schaeffel F, Artal P (2014) Retinal cell imaging in myopic chickens using adaptive optics multiphoton microscopy. Biomed Opt Express 5(3):664–674. https://doi.org/10.1364/boe.5.000664
Cai YL, Zou YC, Lei JH, Zeng GP, Wang Y (2016) The investigation on the role of mitochondrial fusion protein 1 in the development of myopia. Indian J Ophthalmol 64(7):500–503. https://doi.org/10.4103/0301-4738.190137
Cakmak AI, Basmak H, Gursoy H, Ozkurt M, Yildirim N, Erkasap N, Bilgec MD, Tuncel N, Colak E (2017) Vasoactive intestinal peptide, a promising agent for myopia? Int J Ophthalmol 10(2):211–216
Casson RJ, Kahawita S, Kong A, Muecke J, Sisaleumsak S, Visonnavong V (2012) Exceptionally low prevalence of refractive error and visual impairment in schoolchildren from Lao People’s Democratic Republic. Ophthalmology 119(10):2021–2027. https://doi.org/10.1016/j.ophtha.2012.03.049
Chakraborty R, Pardue MT (2015) Molecular and biochemical aspects of the retina on refraction. Prog Mol Biol Transl Sci 134:249–267. https://doi.org/10.1016/bs.pmbts.2015.06.013
Chakraborty R, Park H, Aung MH, Tan CC, Sidhu CS, Iuvone PM, Pardue MT (2014) Comparison of refractive development and retinal dopamine in OFF pathway mutant and C57BL/6J wild-type mice. Mol vis 20:1318–1327
Chakraborty R, Ostrin LA, Nickla DL, Iuvone PM, Pardue MT, Stone RA (2018) Circadian rhythms, refractive development, and myopia. Ophthalmic Physiol Opt 38(3):217–245. https://doi.org/10.1111/opo.12453
Chakraborty R, Yang V, Park HN, Landis EG, Dhakal S, Motz CT, Bergen MA, Iuvone PM, Pardue MT (2019) Lack of cone mediated retinal function increases susceptibility to form-deprivation myopia in mice. Exp Eye Res 180:226–230. https://doi.org/10.1016/j.exer.2018.12.021
Chakraborty R, Landis EG, Mazade R, Yang V, Strickland R, Hattar S, Stone RA, Iuvone PM, Pardue MT (2022) Melanopsin modulates refractive development and myopia. Exp Eye Res 214:108866. https://doi.org/10.1016/j.exer.2021.108866
Chang TC, Mendell JT (2007) microRNAs in vertebrate physiology and human disease. Annu Rev Genomics Hum Genet 8:215–239. https://doi.org/10.1146/annurev.genom.8.080706.092351
Chebib M, Hinton T, Schmid KL, Brinkworth D, Qian H, Matos S, Kim HL, Abdel-Halim H, Kumar RJ, Johnston GA, Hanrahan JR (2009) Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. J Pharmacol Exp Ther 328(2):448–457. https://doi.org/10.1124/jpet.108.146464
Chen KC, Hsi E, Hu CY, Chou WW, Liang CL, Juo SH (2012) MicroRNA-328 may influence myopia development by mediating the PAX6 gene. Invest Ophthalmol vis Sci 53(6):2732–2739. https://doi.org/10.1167/iovs.11-9272
Chen S, Zhi Z, Ruan Q, Liu Q, Li F, Wan F, Reinach PS, Chen J, Qu J, Zhou X (2017) Bright light suppresses form-deprivation myopia development with activation of dopamine D1 receptor signaling in the ON pathway in retina. Invest Ophthalmol vis Sci 58(4):2306–2316. https://doi.org/10.1167/iovs.16-20402
Chen P, Xu L, Zhang J, Cai X, Yang Y, Yu J, Qiu J, Ge J, Yu K, Zhuang J (2020) Up-regulation of SorCS1, an important sorting receptor, in the retina of a form-deprivation rat model. Cell Mol Neurobiol 40(3):395–405. https://doi.org/10.1007/s10571-019-00740-1
Cheng ZY, Wang XP, Schmid KL, Han YF, Han XG, Tang HW, Tang X (2015) GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs. Biomed Res Int 2015:207312. https://doi.org/10.1155/2015/207312
Chierigo A, Ferro Desideri L, Traverso CE, Vagge A (2022) The role of atropine in preventing myopia progression: an update. Pharmaceutics. https://doi.org/10.3390/pharmaceutics14050900
Chun RK, Shan SW, Lam TC, Wong CL, Li KK, Do CW, To CH (2015) Cyclic adenosine monophosphate activates retinal apolipoprotein A1 expression and inhibits myopic eye growth. Invest Ophthalmol vis Sci 56(13):8151–8157. https://doi.org/10.1167/iovs.14-14233(InChinese)
Ciranna L, Catania MV (2014) 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders. Front Cell Neurosci 8:250. https://doi.org/10.3389/fncel.2014.00250
Cohen Y, Peleg E, Belkin M, Polat U, Solomon AS (2012) Ambient illuminance, retinal dopamine release and refractive development in chicks. Exp Eye Res 103:33–40. https://doi.org/10.1016/j.exer.2012.08.004
Cordain L, Eades MR, Eades MD (2003) Hyperinsulinemic diseases of civilization: more than just Syndrome X. Comp Biochem Physiol A Mol Integr Physiol 136(1):95–112. https://doi.org/10.1016/s1095-6433(03)00011-4
Crewther DP, Crewther SG (1990) Pharmacological modification of eye growth in normally reared and visually deprived chicks. Curr Eye Res 9(8):733–740. https://doi.org/10.3109/02713689008999568
Crewther DP, Crewther SG (2002) Refractive compensation to optical defocus depends on the temporal profile of luminance modulation of the environment. NeuroReport 13(8):1029–1032. https://doi.org/10.1097/00001756-200206120-00010
Crewther DP, Crewther SG, Xie RZ (1996) Changes in eye growth produced by drugs which affect retinal ON or OFF responses to light. J Ocul Pharmacol Ther 12(2):193–208. https://doi.org/10.1089/jop.1996.12.193
Crewther SG, Liang H, Junghans BM, Crewther DP (2006) Ionic control of ocular growth and refractive change. Proc Natl Acad Sci U S A 103(42):15663–15668. https://doi.org/10.1073/pnas.0607241103
Crewther SG, Murphy MJ, Crewther DP (2008) Potassium channel and NKCC cotransporter involvement in ocular refractive control mechanisms. PLoS ONE. https://doi.org/10.1371/journal.pone.0002839
Cui P, Li XY, Zhao Y, Li Q, Gao F, Li LZ, Yin N, Sun XH, Wang Z (2017) Activation of dopamine D1 receptors enhances the temporal summation and excitability of rat retinal ganglion cells. Neuroscience 355:71–83. https://doi.org/10.1016/j.neuroscience.2017.04.046
De Deurwaerdère P, Di Giovanni G (2017) Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications. Prog Neurobiol 151:175–236. https://doi.org/10.1016/j.pneurobio.2016.03.004
Ding X, Morgan IG, Hu Y, Yuan Z, He M (2022) Exposure to the life of a school child rather than age determines myopic shifts in refraction in school children. Invest Ophthalmol vis Sci 63(3):15. https://doi.org/10.1167/iovs.63.3.15
Djamgoz MB, Wagner HJ (1992) Localization and function of dopamine in the adult vertebrate retina. Neurochem Int 20(2):139–191. https://doi.org/10.1016/0197-0186(92)90166-o
Dolgin E (2015) The myopia boom. Nature 519(7543):276–278. https://doi.org/10.1038/519276a
Dong F, Zhi Z, Pan M, Xie R, Qin X, Lu R, Mao X, Chen JF, Willcox MD, Qu J, Zhou X (2011) Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs. Mol vis 17:2824–2834
Dong L, Shi XH, Li YF, Jiang X, Wang YX, Lan YJ, Wu HT, Jonas JB, Wei WB (2020) Blockade of epidermal growth factor and its receptor and axial elongation in experimental myopia. Faseb j 34(10):13654–13670. https://doi.org/10.1096/fj.202001095RR
Doyle SE, Grace MS, McIvor W, Menaker M (2002) Circadian rhythms of dopamine in mouse retina: the role of melatonin. Vis Neurosci 19(5):593–601. https://doi.org/10.1017/s0952523802195058
Duan X, Lu Q, Xue P, Zhang H, Dong Z, Yang F, Wang N (2008) Proteomic analysis of aqueous humor from patients with myopia. Mol vis 14:370–377
Eastlake K, Luis J, Limb GA (2020) Potential of Müller Glia for Retina Neuroprotection. Curr Eye Res 45(3):339–348. https://doi.org/10.1080/02713683.2019.1648831
Euler T, Haverkamp S, Schubert T, Baden T (2014) Retinal bipolar cells: elementary building blocks of vision. Nat Rev Neurosci 15(8):507–519. https://doi.org/10.1038/nrn3783
Exton JH (1987) Mechanisms of hormonal regulation of hepatic glucose metabolism. Diabetes Metab Rev 3(1):163–183. https://doi.org/10.1002/dmr.5610030108
Feldkaemper MP, Schaeffel F (2007) Insulin inhibits compensation of plus lenses in chicks and stimulates myopia development. Invest Ophthalmol vis Sci 48(13):5924–5924
Feldkaemper M, Schaeffel F (2013) An updated view on the role of dopamine in myopia. Exp Eye Res 114:106–119. https://doi.org/10.1016/j.exer.2013.02.007
Feldkaemper MP, Neacsu I, Schaeffel F (2009a) Insulin acts as a powerful stimulator of axial myopia in chicks. Invest Ophthalmol vis Sci 50(1):13–23. https://doi.org/10.1167/iovs.08-1702
Fischer AJ, McGuire JJ, Schaeffel F, Stell WK (1999) Light- and focus-dependent expression of the transcription factor ZENK in the chick retina. Nat Neurosci 2(8):706–712. https://doi.org/10.1038/11167
French AN, Ashby RS, Morgan IG, Rose KA (2013) Time outdoors and the prevention of myopia. Exp Eye Res 114:58–68. https://doi.org/10.1016/j.exer.2013.04.018
Frost MR, Norton TT (2012) Alterations in protein expression in tree shrew sclera during development of lens-induced myopia and recovery. Invest Ophthalmol vis Sci 53(1):322–336. https://doi.org/10.1167/iovs.11-8354
Fujieda H, Hamadanizadeh SA, Wankiewicz E, Pang SF, Brown GM (1999) Expression of mt1 melatonin receptor in rat retina: evidence for multiple cell targets for melatonin. Neuroscience 93(2):793–799. https://doi.org/10.1016/s0306-4522(99)00111-6
Fujieda H, Scher J, Hamadanizadeh SA, Wankiewicz E, Pang SF, Brown GM (2000) Dopaminergic and GABAergic amacrine cells are direct targets of melatonin: immunocytochemical study of mt1 melatonin receptor in guinea pig retina. Vis Neurosci 17(1):63–70. https://doi.org/10.1017/s0952523800171068
Garbarino-Pico E, Carpentieri AR, Contin MA, Sarmiento MI, Brocco MA, Panzetta P, Rosenstein RE, Caputto BL, Guido ME (2004) Retinal ganglion cells are autonomous circadian oscillators synthesizing N-acetylserotonin during the day. J Biol Chem 279(49):51172–51181. https://doi.org/10.1074/jbc.M309248200
George A, Schmid KL, Pow DV (2005) Retinal serotonin, eye growth and myopia development in chick. Exp Eye Res 81(5):616–625. https://doi.org/10.1016/j.exer.2005.03.021
Gerbeth C, Schmidt O, Rao S, Harbauer AB, Mikropoulou D, Opalińska M, Guiard B, Pfanner N, Meisinger C (2013) Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases. Cell Metab 18(4):578–587. https://doi.org/10.1016/j.cmet.2013.09.006
Gianesini C, Clesse D, Tosini G, Hicks D, Laurent V (2015) Unique regulation of the melatonin synthetic pathway in the retina of diurnal female Arvicanthis ansorgei (Rodentia). Endocrinology 156(9):3292–3308. https://doi.org/10.1210/en.2015-1267
Gisbert S, Schaeffel F (2018) M to L cone ratios determine eye sizes and baseline refractions in chickens. Exp Eye Res 172:104–111. https://doi.org/10.1016/j.exer.2018.03.029
Goel M, Mangel SC (2021) Dopamine-mediated circadian and light/dark-adaptive modulation of chemical and electrical synapses in the outer retina. Front Cell Neurosci 15:647541. https://doi.org/10.3389/fncel.2021.647541
Goldschmidt E, Jacobsen N (2014) Genetic and environmental effects on myopia development and progression. Eye (lond) 28(2):126–133. https://doi.org/10.1038/eye.2013.254
Gouya C, Kelly D, Kim M, Wilburn V, Liu O, Lam E, Tieu B, Gonzalez-Fernandez F (2022) Absence of interphotoreceptor retinoid-binding protein (IRBP, RBP3) in transgenic rats causes photoreceptor degeneration and myopia. Investigative Ophthalmol Visual Sci 63(7):1873
Goyal V, DeVera C, Laurent V, Sellers J, Chrenek MA, Hicks D, Baba K, Iuvone PM, Tosini G (2020) Dopamine 2 receptor signaling controls the daily burst in phagocytic activity in the mouse retinal pigment epithelium. Invest Ophthalmol vis Sci 61(5):10. https://doi.org/10.1167/iovs.61.5.10
Grewal JS, Mukhin YV, Garnovskaya MN, Raymond JR, Greene EL (1999) Serotonin 5-HT2A receptor induces TGF-beta1 expression in mesangial cells via ERK: proliferative and fibrotic signals. Am J Physiol 276(6):F922-930. https://doi.org/10.1152/ajprenal.1999.276.6.F922
Grochowski ET, Pietrowska K, Kowalczyk T, Mariak Z, Kretowski A, Ciborowski M, Dmuchowska DA (2020) Omics in Myopia. J Clin Med. https://doi.org/10.3390/jcm9113464
Grudzińska EM, Zaborski D, Modrzejewska M (2022) Correlation between retrobulbar blood flow parameters and retinal nerve fiber, ganglion cell and inner plexus layer thickness in myopia. Eur J Ophthalmol 32(1):643–650. https://doi.org/10.1177/1120672121992007
Guggenheim JA, Clark R, Cui J, Terry L, Patasova K, Haarman AEG, Musolf AM, Verhoeven VJM, Klaver CCW, Bailey-Wilson JE, Hysi PG, Williams C (2022) Whole exome sequence analysis in 51 624 participants identifies novel genes and variants associated with refractive error and myopia. Hum Mol Genet 31(11):1909–1919. https://doi.org/10.1093/hmg/ddac004
Guo SS, Sivak JG, Callender MG, Diehl-Jones B (1995) Retinal dopamine and lens-induced refractive errors in chicks. Curr Eye Res 14(5):385–389. https://doi.org/10.3109/02713689508999936
Guo X, Fu M, Ding X, Morgan IG, Zeng Y, He M (2017) Significant axial elongation with minimal change in refraction in 3- to 6-year-old Chinese preschoolers: the Shenzhen kindergarten eye study. Ophthalmology 124(12):1826–1838. https://doi.org/10.1016/j.ophtha.2017.05.030
Guoping L, Xiang Y, Jianfeng W, Dadong G, Jie H, Wenjun J, Junguo G, Hongsheng B (2017) Alterations of glutamate and γ-aminobutyric acid expressions in normal and myopic eye development in guinea pigs. Invest Ophthalmol vis Sci 58(2):1256–1265. https://doi.org/10.1167/iovs.16-21130
Hasan RN, Phukan S, Harada S (2003) Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial cells. Arterioscler Thromb Vasc Biol 23(6):988–993. https://doi.org/10.1161/01.Atv.0000071351.07784.19
Hattar S, Liao HW, Takao M, Berson DM, Yau KW (2002) Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295(5557):1065–1070. https://doi.org/10.1126/science.1069609
He M, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, Smith W, Rose K, Morgan IG (2015) Effect of time spent outdoors at school on the development of myopia among children in China: a randomized clinical trial. JAMA 314(11):1142–1148. https://doi.org/10.1001/jama.2015.10803
Hendriks M, Verhoeven VJM, Buitendijk GHS, Polling JR, Meester-Smoor MA, Hofman A, Kamermans M, Ingeborgh van den Born L, Klaver CCW (2017) Development of refractive errors-what can we learn from inherited retinal dystrophies? Am J Ophthalmol 182:81–89. https://doi.org/10.1016/j.ajo.2017.07.008
Hirata A, Negi A (1998) Morphological changes of choriocapillaris in experimentally induced chick myopia. Graefes Arch Clin Exp Ophthalmol 236(2):132–137. https://doi.org/10.1007/s004170050053
Hn P, Jabbar SB, Tan CC, Sidhu CS, Abey J, Aseem F, Schmid G, Iuvone PM, Pardue MT (2014) Visually-driven ocular growth in mice requires functional rod photoreceptors. Invest Ophthalmol vis Sci 55(10):6272–6279. https://doi.org/10.1167/iovs.14-14648
Hoffmann M, Schaeffel F (1996) Melatonin and deprivation myopia in chickens. Neurochem Int 28(1):95–107. https://doi.org/10.1016/0197-0186(95)00050-i
Holden B, Fricke T, Wilson D, Jong M, Naidoo K, Sankaridurg P, Wong T, Naduvilath T, Resnikoff S (2016) Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology 123(5):1036–1042. https://doi.org/10.1016/j.ophtha.2016.01.006
Holder GE (2001) Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. Prog Retin Eye Res 20(4):531–561. https://doi.org/10.1016/s1350-9462(00)00030-6
Honda S, Fujii S, Sekiya Y, Yamamoto M (1996) Retinal control on the axial length mediated by transforming growth factor-beta in chick eye. Invest Ophthalmol vis Sci 37(12):2519–2526
Hoseini-Yazdi H, Read SA, Alonso-Caneiro D, Collins MJ (2021) Retinal OFF-pathway overstimulation leads to greater accommodation-induced choroidal thinning. Invest Ophthalmol vis Sci 62(13):5. https://doi.org/10.1167/iovs.62.13.5
Hu M, Zhong H, Liu Y, Liu R, Chen C, Chu R (2008) Expression of rhodopsin for experimental myopia of form-deprivation and defocus in guinea pig. Yan Ke Xue Bao 24(1):1–5 ((In Chinese))
Huang F, Yan T, Shi F, An J, Xie R, Zheng F, Li Y, Chen J, Qu J, Zhou X (2014) Activation of dopamine D2 receptor is critical for the development of form-deprivation myopia in the C57BL/6 mouse. Invest Ophthalmol vis Sci 55(9):5537–5544. https://doi.org/10.1167/iovs.13-13211
Huang C, Wang L, Song H, Wu C (2019) MiR-29a inhibits the progression of oral squamous cell carcinoma by targeting Wnt/β-catenin signaling pathway. Artif Cells Nanomed Biotechnol 47(1):3037–3042. https://doi.org/10.1080/21691401.2019.1576712
Huang F, Wang Q, Yan T, Tang J, Hou X, Shu Z, Wan F, Yang Y, Qu J, Zhou X (2020) The role of the dopamine D2 receptor in form-deprivation myopia in mice: studies with full and partial D2 receptor agonists and knockouts. Invest Ophthalmol vis Sci 61(6):47. https://doi.org/10.1167/iovs.61.6.47
Huang F, Shu Z, Huang Q, Chen K, Yan W, Wu W, Yang J, Wang Q, Wang F, Zhang C, Qu J, Zhou X (2022) Retinal dopamine D2 receptors participate in the development of myopia in mice. Invest Ophthalmol vis Sci 63(1):24. https://doi.org/10.1167/iovs.63.1.24
Hwang CK, Chaurasia SS, Jackson CR, Chan GC, Storm DR, Iuvone PM (2013) Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci 33(38):14989–14997. https://doi.org/10.1523/jneurosci.2039-13.2013
Inagaki N, Chihara K, Arimura N, Ménager C, Kawano Y, Matsuo N, Nishimura T, Amano M, Kaibuchi K (2001) CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci 4(8):781–782. https://doi.org/10.1038/90476
Iuvone PM, Tigges M, Fernandes A, Tigges J (1989) Dopamine synthesis and metabolism in rhesus monkey retina: development, aging, and the effects of monocular visual deprivation. Vis Neurosci 2(5):465–471. https://doi.org/10.1017/s0952523800012360
Jacobi FK, Zrenner E, Broghammer M, Pusch CM (2005) A genetic perspective on myopia. Cell Mol Life Sci 62(7–8):800–808. https://doi.org/10.1007/s00018-004-4353-z
Jaworski A, Gentle A, Zele AJ, Vingrys AJ, McBrien NA (2006) Altered visual sensitivity in axial high myopia: a local postreceptoral phenomenon? Invest Ophthalmol vis Sci 47(8):3695–3702. https://doi.org/10.1167/iovs.05-1569
Jiang L, Long K, Schaeffel F, Zhou X, Zheng Y, Ying H, Lu F, Stell WK, Qu J (2014) Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus). Invest Ophthalmol vis Sci 55(11):7508–7519. https://doi.org/10.1167/iovs.14-14294
Jiang B, Huo Y, Gu Y, Wang J (2017) The role of microRNAs in myopia. Graefes Arch Clin Exp Ophthalmol 255(1):7–13. https://doi.org/10.1007/s00417-016-3532-6
Jiang X, Pardue MT, Mori K, Ikeda SI, Torii H, D’Souza S, Lang RA, Kurihara T, Tsubota K (2021) Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.2018840118
Jiang X, Xu Z, Soorma T, Tariq A, Bhatti T, Baneke AJ, Pontikos N, Leo SM, Webster AR, Williams KM, Hammond CJ, Hysi PG, Mahroo OA (2022) Electrical responses from human retinal cone pathways associate with a common genetic polymorphism implicated in myopia. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.2119675119
Jin NG, Chuang AZ, Masson PJ, Ribelayga CP (2015) Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina. J Physiol 593(7):1597–1631. https://doi.org/10.1113/jphysiol.2014.284919
Jobling AI, Nguyen M, Gentle A, McBrien NA (2004) Isoform-specific changes in scleral transforming growth factor-beta expression and the regulation of collagen synthesis during myopia progression. J Biol Chem 279(18):18121–18126. https://doi.org/10.1074/jbc.M400381200
Jonas JB, Ohno-Matsui K, Holbach L, Panda-Jonas S (2017) Retinal pigment epithelium cell density in relationship to axial length in human eyes. Acta Ophthalmol. https://doi.org/10.1111/aos.13188
Jostrup R, Shen W, Burrows JT, Sivak JG, McConkey BJ, Singer TD (2009) Identification of myopia-related marker proteins in tilapia retinal, RPE, and choroidal tissue following induced form deprivation. Curr Eye Res 34(11):966–975. https://doi.org/10.3109/02713680903244138
Karouta C, Kucharski R, Hardy K, Thomson K, Maleszka R, Morgan I, Ashby R (2021) Transcriptome-based insights into gene networks controlling myopia prevention. Faseb j. https://doi.org/10.1096/fj.202100350RR
Kato S, Teranishi T, Kuo CH, Negishi K (1982) 5-hydroxytryptamine stimulates [3H]dopamine release from the fish retina. J Neurochem 39(2):493–498. https://doi.org/10.1111/j.1471-4159.1982.tb03971.x
Kazula A, Nowak JZ, Iuvone PM (1993) Regulation of melatonin and dopamine biosynthesis in chick retina: the role of GABA. Vis Neurosci 10(4):621–629. https://doi.org/10.1017/s0952523800005320
Kearney S, O’Donoghue L, Pourshahidi LK, Cobice D, Saunders KJ (2017) Myopes have significantly higher serum melatonin concentrations than non-myopes. Ophthalmic Physiol Opt 37(5):557–567. https://doi.org/10.1111/opo.12396
Kevany BM, Palczewski K (2010) Phagocytosis of retinal rod and cone photoreceptors. Physiology (bethesda) 25(1):8–15. https://doi.org/10.1152/physiol.00038.2009
Kiefer AK, Tung JY, Do CB, Hinds DA, Mountain JL, Francke U, Eriksson N (2013) Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia. PLoS Genet. https://doi.org/10.1371/journal.pgen.1003299
Kilbourne EJ, Widom R, Harnish DC, Malik S, Karathanasis SK (1995) Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription. J Biol Chem 270(12):7004–7010. https://doi.org/10.1074/jbc.270.12.7004
Ko GY (2020) Circadian regulation in the retina: From molecules to network. Eur J Neurosci 51(1):194–216. https://doi.org/10.1111/ejn.14185
Kothmann WW, Massey SC, O’Brien J (2009) Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling. J Neurosci 29(47):14903–14911. https://doi.org/10.1523/jneurosci.3436-09.2009
Kozomara A, Birgaoanu M, Griffiths-Jones S (2019) miRBase: from microRNA sequences to function. Nucleic Acids Res 47(D1):D155–D162. https://doi.org/10.1093/nar/gky1141
Kubrusly RC, Panizzutti R, Gardino PF, Stutz B, Reis RA, Ventura AL, de Mello MC, de Mello FG (2008) Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Neurochem Int 53(3–4):63–70. https://doi.org/10.1016/j.neuint.2008.05.002
Kunst S, Wolloscheck T, Kelleher DK, Wolfrum U, Sargsyan SA, Iuvone PM, Baba K, Tosini G, Spessert R (2015) Pgc-1α and Nr4a1 are target genes of circadian melatonin and dopamine release in murine retina. Invest Ophthalmol vis Sci 56(10):6084–6094. https://doi.org/10.1167/iovs.15-17503
Lam TC, Li K-K, Lo SCL, Guggenheim JA, To CH (2007a) Application of fluorescence difference gel electrophoresis technology in searching for protein biomarkers in chick myopia. J Proteome Res 6(11):4135–4149. https://doi.org/10.1021/pr0701097
Lan W, Zhao F, Lin L, Li Z, Zeng J, Yang Z, Morgan IG (2013) Refractive errors in 3–6 year-old Chinese children: a very low prevalence of myopia? PLoS ONE 8(10):e78003. https://doi.org/10.1371/journal.pone.0078003
Lan W, Yang Z, Feldkaemper M, Schaeffel F (2016) Changes in dopamine and ZENK during suppression of myopia in chicks by intense illuminance. Exp Eye Res 145:118–124. https://doi.org/10.1016/j.exer.2015.11.018
Li Z, Qu J, Xu X, Zhou X, Zou H, Wang N, Li T, Hu X, Zhao Q, Chen P, Li W, Huang K, Yang J, He Z, Ji J, Wang T, Li J, Li Y, Liu J, Zeng Z, Feng G, He L, Shi Y (2011) A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population. Hum Mol Genet 20(14):2861–2868. https://doi.org/10.1093/hmg/ddr169
Li B, Luo X, Li T, Zheng C, Ji S, Ma Y, Zhang S, Zhou X (2016a) Effects of constant flickering light on refractive status, 5-HT and 5-HT2A receptor in guinea pigs. PLoS ONE 11(12):e0167902. https://doi.org/10.1371/journal.pone.0167902
Li DD, Zhong BW, Zhang HX, Zhou HY, Luo J, Liu Y, Xu GC, Luan CS, Fang J (2016b) Inhibition of the oxidative stress-induced miR-23a protects the human retinal pigment epithelium (RPE) cells from apoptosis through the upregulation of glutaminase and glutamine uptake. Mol Biol Rep 43(10):1079–1087. https://doi.org/10.1007/s11033-016-4041-8
Li M, Yuan Y, Chen Q, Me R, Gu Q, Yu Y, Sheng M, Ke B (2016c) Expression of Wnt/β-catenin signaling pathway and its regulatory role in type I collagen with TGF-β1 in scleral fibroblasts from an experimentally induced myopia guinea pig model. J Ophthalmol 2016:5126560. https://doi.org/10.1155/2016/5126560
Liang H, Crewther DP, Crewther SG, Barila AM (1995) A role for photoreceptor outer segments in the induction of deprivation myopia. Vision Res 35(9):1217–1225. https://doi.org/10.1016/0042-6989(94)00241-d
Liang CL, Hsi E, Chen KC, Pan YR, Wang YS, Juo SH (2011) A functional polymorphism at 3’UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese. Invest Ophthalmol vis Sci 52(6):3500–3505. https://doi.org/10.1167/iovs.10-5859
Lin H, Qian J, Castillo AC, Long B, Keyes KT, Chen G, Ye Y (2011) Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells. Invest Ophthalmol vis Sci 52(9):6308–6314. https://doi.org/10.1167/iovs.10-6632
Liu Y, Chen Y, Wang Y, Zhang X, Gao K, Chen S, Zhang X (2018) microRNA profiling in glaucoma eyes with varying degrees of optic neuropathy by using next-generation sequencing. Invest Ophthalmol vis Sci 59(7):2955–2966. https://doi.org/10.1167/iovs.17-23599
Liu AL, Liu YF, Wang G, Shao YQ, Yu CX, Yang Z, Zhou ZR, Han X, Gong X, Qian KW, Wang LQ, Ma YY, Zhong YM, Weng SJ, Yang XL (2022a) The role of ipRGCs in ocular growth and myopia development. Sci Adv. https://doi.org/10.1126/sciadv.abm9027
Liu S, Chen H, Ma W, Zhong Y, Liang Y, Gu L, Lu X, Li J (2022b) Non-coding RNAs and related molecules associated with form-deprivation myopia in mice. J Cell Mol Med 26(1):186–194. https://doi.org/10.1111/jcmm.17071
Lubiński W (1991) Electroretinogram of the “pattern” type of eyes with medium grade myopia. Klin Oczna 93(10–11):284–285
Ludueña RF (1993) Are tubulin isotypes functionally significant. Mol Biol Cell 4(5):445–457. https://doi.org/10.1091/mbc.4.5.445
Lukasiewicz PD, Shields CR (1998) A diversity of GABA receptors in the retina. Semin Cell Dev Biol 9(3):293–299. https://doi.org/10.1006/scdb.1998.0238
Luo X, Frishman LJ (2011) Retinal pathway origins of the pattern electroretinogram (PERG). Invest Ophthalmol vis Sci 52(12):8571–8584. https://doi.org/10.1167/iovs.11-8376
Ma M, Zhang Z, Du E, Zheng W, Gu Q, Xu X, Ke B (2014) Wnt signaling in form deprivation myopia of the mice retina. PLoS ONE 9(4):e91086. https://doi.org/10.1371/journal.pone.0091086
Mao JF, Liu SZ (2013) Mechanism of the DL-alpha-aminoadipic acid inhibitory effect on form-deprived myopia in guinea pig. Int J Ophthalmol 6(1):19–22. https://doi.org/10.3980/j.issn.2222-3959.2013.01.04
Markand S, Baskin NL, Chakraborty R, Landis E, Wetzstein SA, Donaldson KJ, Priyadarshani P, Alderson SE, Sidhu CS, Boatright JH, Iuvone PM, Pardue MT, Nickerson JM (2016) IRBP deficiency permits precocious ocular development and myopia. Mol vis 22:1291–1308
Masland RH (2001) The fundamental plan of the retina. Nat Neurosci 4(9):877–886. https://doi.org/10.1038/nn0901-877
Masland RH (2012) The neuronal organization of the retina. Neuron 76(2):266–280. https://doi.org/10.1016/j.neuron.2012.10.002
Mathis U, Feldkaemper M, Wang M, Schaeffel F (2020) Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken. Graefes Arch Clin Exp Ophthalmol 258(2):319–333. https://doi.org/10.1007/s00417-019-04573-y
McCarthy CS, Megaw P, Devadas M, Morgan IG (2007) Dopaminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia. Exp Eye Res 84(1):100–107. https://doi.org/10.1016/j.exer.2006.09.018
McGlinn AM, Baldwin DA, Tobias JW, Budak MT, Khurana TS, Stone RA (2007) Form-deprivation myopia in chick induces limited changes in retinal gene expression. Invest Ophthalmol vis Sci 48(8):3430–3436. https://doi.org/10.1167/iovs.06-1538
McKerracher L, Essagian C, Aguayo AJ (1993) Marked increase in beta-tubulin mRNA expression during regeneration of axotomized retinal ganglion cells in adult mammals. J Neurosci 13(12):5294–5300. https://doi.org/10.1523/jneurosci.13-12-05294.1993
Megaw PL, Morgan IG, Boelen MK (1997) Dopaminergic behaviour in chicken retina and the effect of form deprivation. Aust N Z J Ophthalmol 25(Suppl 1):S76-78. https://doi.org/10.1111/j.1442-9071.1997.tb01764.x
Megaw P, Morgan I, Boelen M (2001) Vitreal dihydroxyphenylacetic acid (DOPAC) as an index of retinal dopamine release. J Neurochem 76(6):1636–1644. https://doi.org/10.1046/j.1471-4159.2001.00145.x
Mei F, Wang J, Chen Z, Yuan Z (2017) Potentially important MicroRNAs in form-deprivation myopia revealed by bioinformatics analysis of MicroRNA profiling. Ophthalmic Res 57(3):186–193. https://doi.org/10.1159/000452421
Milićević N, Ait-Hmyed Hakkari O, Bagchi U, Sandu C, Jongejan A, Moerland PD, Ten Brink JB, Hicks D, Bergen AA, Felder-Schmittbuhl MP (2021) Core circadian clock genes Per1 and Per2 regulate the rhythm in photoreceptor outer segment phagocytosis. Faseb j 35(7):e21722. https://doi.org/10.1096/fj.202100293RR
Miyake M, Yamashiro K, Tabara Y, Suda K, Morooka S, Nakanishi H, Khor CC, Chen P, Qiao F, Nakata I, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Meguro A, Kusuhara S, Polasek O, Hayward C, Wright AF, Campbell H, Richardson AJ, Schache M, Takeuchi M, Mackey DA, Hewitt AW, Cuellar G, Shi Y, Huang L, Yang Z, Leung KH, Kao PYP, Yap MKH, Yip SP, Moriyama M, Ohno-Matsui K, Mizuki N, MacGregor S, Vitart V, Aung T, Saw SM, Tai ES, Wong TY, Cheng CY, Baird PN, Yamada R, Matsuda F, Yoshimura N (2015) Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia. Nat Commun 6:6689. https://doi.org/10.1038/ncomms7689
Morgan IG (2003) The biological basis of myopic refractive error. Clin Exp Optom 86(5):276–288
Morgan IG, Ashby RS (2017) Bright light blocks the development of form deprivation myopia in mice, acting on D1 dopamine receptors. Invest Ophthalmol vis Sci 58(4):2317. https://doi.org/10.1167/iovs.17-21871
Morgan I, Rose K (2005) How genetic is school myopia? Prog Retin Eye Res 24(1):1–38. https://doi.org/10.1016/j.preteyeres.2004.06.004
Morgan IG, Rose KA (2019) Myopia: is the nature-nurture debate finally over? Clin Exp Optom 102(1):3–17. https://doi.org/10.1111/cxo.12845
Morgan IG, Ohno-Matsui K, Saw SM (2012) Myopia Lancet 379(9827):1739–1748. https://doi.org/10.1016/s0140-6736(12)60272-4
Morgan IG, French AN, Ashby RS, Guo X, Ding X, He M, Rose KA (2018) The epidemics of myopia: Aetiology and prevention. Prog Retin Eye Res 62:134–149. https://doi.org/10.1016/j.preteyeres.2017.09.004
Morgan IG, Wu PC, Ostrin LA, Tideman JWL, Yam JC, Lan W, Baraas RC, He X, Sankaridurg P, Saw SM, French AN, Rose KA, Guggenheim JA (2021) IMI risk factors for myopia. Invest Ophthalmol vis Sci 62(5):3. https://doi.org/10.1167/iovs.62.5.3
Morin LP (1999) Serotonin and the regulation of mammalian circadian rhythmicity. Ann Med 31(1):12–33. https://doi.org/10.3109/07853899909019259
Naidoo KS, Fricke TR, Frick KD, Jong M, Naduvilath TJ, Resnikoff S, Sankaridurg P (2019) Potential lost productivity resulting from the global burden of myopia: systematic review, meta-analysis, and modeling. Ophthalmology 126(3):338–346. https://doi.org/10.1016/j.ophtha.2018.10.029
Nakamura F, Ohshima T, Goshima Y (2020) Collapsin response mediator proteins: their biological functions and pathophysiology in neuronal development and regeneration. Front Cell Neurosci 14:188. https://doi.org/10.3389/fncel.2020.00188
Nickla DL, Totonelly K, Dhillon B (2010) Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks. Exp Eye Res 91(5):715–720. https://doi.org/10.1016/j.exer.2010.08.021
Nilsson SF, Bill A (1984) Vasoactive intestinal polypeptide (VIP): effects in the eye and on regional blood flows. Acta Physiol Scand 121(4):385–392. https://doi.org/10.1111/j.1748-1716.1984.tb07470.x
Nir I, Haque R, Iuvone PM (2000) Diurnal metabolism of dopamine in the mouse retina. Brain Res 870(1–2):118–125. https://doi.org/10.1016/s0006-8993(00)02409-4
Norton TT, Essinger JA, McBrien NA (1994) Lid-suture myopia in tree shrews with retinal ganglion cell blockade. Vis Neurosci 11(1):143–153. https://doi.org/10.1017/s0952523800011184
Nowak JZ, E ZU, Zawilska J, (1989) Melatonin and its generating system in vertebrate retina: circadian rhythm, effect of environmental lighting and interaction with dopamine. Neurochem Int 14(4):397–406. https://doi.org/10.1016/0197-0186(89)90027-2
Ohngemach S, Hagel G, Schaeffel F (1997) Concentrations of biogenic amines in fundal layers in chickens with normal visual experience, deprivation, and after reserpine application. Vis Neurosci 14(3):493–505. https://doi.org/10.1017/s0952523800012153
Ohno-Matsui K, Lai TY, Lai CC, Cheung CM (2016) Updates of pathologic myopia. Prog Retin Eye Res 52:156–187. https://doi.org/10.1016/j.preteyeres.2015.12.001
Oner A, Gumus K, Arda H, Karakucuk S, Mirza E (2009) Pattern electroretinographic recordings in eyes with myopia. Eye Contact Lens 35(5):238–241. https://doi.org/10.1097/ICL.0b013e3181b343d9
Pan F (2019) Defocused image changes signaling of ganglion cells in the mouse retina. Cells. https://doi.org/10.3390/cells8070640
Pan M, Jiao S, Reinach PS, Yan J, Yang Y, Li Q, Srinivasalu N, Qu J, Zhou X (2018) Opposing effects of PPARα agonism and antagonism on refractive development and form deprivation myopia in guinea pigs. Invest Ophthalmol vis Sci 59(15):5803–5815. https://doi.org/10.1167/iovs.17-22297
Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T (2005) Illumination of the melanopsin signaling pathway. Science 307(5709):600–604. https://doi.org/10.1126/science.1105121
Papastergiou GI, Schmid GF, Laties AM, Pendrak K, Lin T, Stone RA (1998) Induction of axial eye elongation and myopic refractive shift in one-year-old chickens. Vision Res 38(12):1883–1888. https://doi.org/10.1016/s0042-6989(97)00347-7
Pardue MT, Faulkner AE, Fernandes A, Yin H, Schaeffel F, Williams RW, Pozdeyev N, Iuvone PM (2008) High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Invest Ophthalmol vis Sci 49(2):706–712. https://doi.org/10.1167/iovs.07-0643
Park H, Tan CC, Faulkner A, Jabbar SB, Schmid G, Abey J, Iuvone PM, Pardue MT (2013) Retinal degeneration increases susceptibility to myopia in mice. Mol vis 19:2068–2079
Paylakhi S, Labelle-Dumais C, Tolman NG, Sellarole MA, Seymens Y, Saunders J, Lakosha H, deVries WN, Orr AC, Topilko P, John SW, Nair KS (2018) Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error. PLoS Genet 14(3):e1007244. https://doi.org/10.1371/journal.pgen.1007244
Pendrak K, Papastergiou GI, Lin T, Laties AM, Stone RA (2000) Choroidal vascular permeability in visually regulated eye growth. Exp Eye Res 70(5):629–637. https://doi.org/10.1006/exer.2000.0825
Penha AM, Burkhardt E, Schaeffel F, Feldkaemper MP (2012) Effects of intravitreal insulin and insulin signaling cascade inhibitors on emmetropization in the chick. Mol vis 18:2608–2622
Phillips C (1990) Aetiology of myopia. Br J Ophthalmol 74(1):47–48. https://doi.org/10.1136/bjo.74.1.47
Platania CBM, Maisto R, Trotta MC, D’Amico M, Rossi S, Gesualdo C, D’Amico G, Balta C, Herman H, Hermenean A, Ferraraccio F, Panarese I, Drago F, Bucolo C (2019) Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach. Br J Pharmacol 176(13):2179–2194. https://doi.org/10.1111/bph.14665
Pozdeyev N, Tosini G, Li L, Ali F, Rozov S, Lee RH, Iuvone PM (2008) Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina. Eur J Neurosci 27(10):2691–2700. https://doi.org/10.1111/j.1460-9568.2008.06224.x
Prigge CL, Yeh PT, Liou NF, Lee CC, You SF, Liu LL, McNeill DS, Chew KS, Hattar S, Chen SK, Zhang DQ (2016) M1 ipRGCs influence visual function through retrograde signaling in the retina. J Neurosci 36(27):7184–7197. https://doi.org/10.1523/jneurosci.3500-15.2016
Qian KW, Li YY, Wu XH, Gong X, Liu AL, Chen WH, Yang Z, Cui LJ, Liu YF, Ma YY, Yu CX, Huang F, Wang Q, Zhou X, Qu J, Zhong YM, Yang XL, Weng SJ (2022) Altered retinal dopamine levels in a melatonin-proficient mouse model of form-deprivation Myopia. Neurosci Bull. https://doi.org/10.1007/s12264-022-00842-9
Qiu X, Kumbalasiri T, Carlson SM, Wong KY, Krishna V, Provencio I, Berson DM (2005) Induction of photosensitivity by heterologous expression of melanopsin. Nature 433(7027):745–749. https://doi.org/10.1038/nature03345
Quint WH, Tadema KCD, de Vrieze E, Lukowicz RM, Broekman S, Winkelman BHJ, Hoevenaars M, de Gruiter HM, van Wijk E, Schaeffel F, Meester-Smoor M, Miller AC, Willemsen R, Klaver CCW, Iglesias AI (2021a) Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Communications Biology 4(1):676. https://doi.org/10.1038/s42003-021-02185-z
Quint WH, Tadema KCD, de Vrieze E, Lukowicz RM, Broekman S, Winkelman BHJ, Hoevenaars M, de Gruiter HM, van Wijk E, Schaeffel F, Meester-Smoor M, Miller AC, Willemsen R, Klaver CCW, Iglesias AI (2021b) Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Commun Biol 4(1):676. https://doi.org/10.1038/s42003-021-02185-z
Rada JA, Wiechmann AF (2006) Melatonin receptors in chick ocular tissues: implications for a role of melatonin in ocular growth regulation. Invest Ophthalmol vis Sci 47(1):25–33. https://doi.org/10.1167/iovs.05-0195
Raghunath A, Perumal E (2015) Micro-RNAs and their roles in eye disorders. Ophthalmic Res 53(4):169–186. https://doi.org/10.1159/000371853
Remé C, Wirz-Justice A, Rhyner A, Hofmann S (1986) Circadian rhythm in the light response of rat retinal disk-shedding and autophagy. Brain Res 369(1–2):356–360. https://doi.org/10.1016/0006-8993(86)90550-0
Rengarajan K, Pohl J, Nickerson J (2001) Photoaffinity labeling of human IRBP with all-trans-retinoic acid. Biochem Biophys Res Commun 284(2):268–274. https://doi.org/10.1006/bbrc.2001.4960
Rizzolo LJ, Peng S, Luo Y, Xiao W (2011) Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium. Prog Retin Eye Res 30(5):296–323. https://doi.org/10.1016/j.preteyeres.2011.06.002
Roecklein KA, Wong PM, Miller MA, Donofry SD, Kamarck ML, Brainard GC (2013) Melanopsin, photosensitive ganglion cells, and seasonal affective disorder. Neurosci Biobehav Rev 37(3):229–239. https://doi.org/10.1016/j.neubiorev.2012.12.009
Rohde K, Hertz H, Rath MF (2019) Homeobox genes in melatonin-producing pinealocytes: Otx2 and Crx act to promote hormone synthesis in the mature rat pineal gland. J Pineal Res 66(4):e12567. https://doi.org/10.1111/jpi.12567
Rohrer B, Tao J, Stell WK (1997) Basic fibroblast growth factor, its high- and low-affinity receptors, and their relationship to form-deprivation myopia in the chick. Neuroscience 79(3):775–787. https://doi.org/10.1016/s0306-4522(97)00042-0
Rose KA, Morgan IG, Ip J, Kifley A, Huynh S, Smith W, Mitchell P (2008) Outdoor activity reduces the prevalence of myopia in children. Ophthalmology 115(8):1279–1285. https://doi.org/10.1016/j.ophtha.2007.12.019
Ross M, Ofri R, Aizenberg I, Abu-Siam M, Pe’er O, Arad D, Rosov A, Gootwine E, Dvir H, Honig H, Obolensky A, Averbukh E, Banin E, Gantz L (2020) Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia. Sci Rep 10(1):19314. https://doi.org/10.1038/s41598-020-76205-z
Sanes JR, Masland RH (2015) The types of retinal ganglion cells: current status and implications for neuronal classification. Annu Rev Neurosci 38:221–246. https://doi.org/10.1146/annurev-neuro-071714-034120
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O’Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J (2015) The sorting receptor SorCS1 regulates trafficking of neurexin and AMPA receptors. Neuron 87(4):764–780. https://doi.org/10.1016/j.neuron.2015.08.007
Schaeffel F, Bartmann M, Hagel G, Zrenner E (1995) Studies on the role of the retinal dopamine/melatonin system in experimental refractive errors in chickens. Vision Res 35(9):1247–1264. https://doi.org/10.1016/0042-6989(94)00221-7
Scher J, Wankiewicz E, Brown GM, Fujieda H (2002) MT(1) melatonin receptor in the human retina: expression and localization. Invest Ophthalmol vis Sci 43(3):889–897
Schiller PH, Sandell JH, Maunsell JH (1986) Functions of the ON and OFF channels of the visual system. Nature 322(6082):824–825. https://doi.org/10.1038/322824a0
Schmid KL, Wildsoet CF (2004) Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks. Optom vis Sci 81(2):137–147. https://doi.org/10.1097/00006324-200402000-00012
Schorderet M, Hof P, Magistretti PJ (1984) The effects of VIP on cyclic AMP and glycogen levels in vertebrate retina. Peptides 5(2):295–298. https://doi.org/10.1016/0196-9781(84)90222-5
Seltner RL, Stell WK (1995) The effect of vasoactive intestinal peptide on development of form deprivation myopia in the chick: a pharmacological and immunocytochemical study. Vision Res 35(9):1265–1270. https://doi.org/10.1016/0042-6989(94)00244-g
Shan SW, Tse DY, Zuo B, To CH, Liu Q, McFadden SA, Chun RK, Bian J, Li KK, Lam TC (2018) Data on differentially expressed proteins in retinal emmetropization process in guinea pig using integrated SWATH-based and targeted-based proteomics. Data Brief 21:1750–1755. https://doi.org/10.1016/j.dib.2018.08.119
Shiota T, Imai K, Qiu J, Hewitt VL, Tan K, Shen HH, Sakiyama N, Fukasawa Y, Hayat S, Kamiya M, Elofsson A, Tomii K, Horton P, Wiedemann N, Pfanner N, Lithgow T, Endo T (2015) Molecular architecture of the active mitochondrial protein gate. Science 349(6255):1544–1548. https://doi.org/10.1126/science.aac6428
Simó R, García-Ramírez M, Higuera M, Hernández C (2009) Apolipoprotein A1 is overexpressed in the retina of diabetic patients. Am J Ophthalmol 147(2):319-325.e311. https://doi.org/10.1016/j.ajo.2008.08.009
Smith EL 3rd, Fox DA, Duncan GC (1991) Refractive-error changes in kitten eyes produced by chronic on-channel blockade. Vision Res 31(5):833–844. https://doi.org/10.1016/0042-6989(91)90150-4
Solouki AM, Verhoeven VJ, van Duijn CM, Verkerk AJ, Ikram MK, Hysi PG, Despriet DD, van Koolwijk LM, Ho L, Ramdas WD, Czudowska M, Kuijpers RW, Amin N, Struchalin M, Aulchenko YS, van Rij G, Riemslag FC, Young TL, Mackey DA, Spector TD, Gorgels TG, Willemse-Assink JJ, Isaacs A, Kramer R, Swagemakers SM, Bergen AA, van Oosterhout AA, Oostra BA, Rivadeneira F, Uitterlinden AG, Hofman A, de Jong PT, Hammond CJ, Vingerling JR, Klaver CC (2010) A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nat Genet 42(10):897–901. https://doi.org/10.1038/ng.663
Stone RA, Kuwayama Y, Laties AM (1987) Regulatory peptides in the eye. Experientia 43(7):791–800. https://doi.org/10.1007/bf01945357
Stone RA, Laties AM, Raviola E, Wiesel TN (1988) Increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates. Proc Natl Acad Sci U S A 85(1):257–260. https://doi.org/10.1073/pnas.85.1.257
Stone RA, Lin T, Laties AM, Iuvone PM (1989) Retinal dopamine and form-deprivation myopia. Proc Natl Acad Sci U S A 86(2):704–706. https://doi.org/10.1073/pnas.86.2.704
Stone RA, Liu J, Sugimoto R, Capehart C, Zhu X, Pendrak K (2003) GABA, experimental myopia, and ocular growth in chick. Invest Ophthalmol vis Sci 44(9):3933–3946. https://doi.org/10.1167/iovs.02-0774
Stone RA, Pendrak K, Sugimoto R, Lin T, Gill AS, Capehart C, Liu J (2006) Local patterns of image degradation differentially affect refraction and eye shape in chick. Curr Eye Res 31(1):91–105. https://doi.org/10.1080/02713680500479517
Stone RA, McGlinn AM, Baldwin DA, Tobias JW, Iuvone PM, Khurana TS (2011) Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia. Invest Ophthalmol vis Sci 52(8):5765–5777. https://doi.org/10.1167/iovs.10-6727
Stone RA, Wei W, Sarfare S, McGeehan B, Engelhart KC, Khurana TS, Maguire MG, Iuvone PM, Nickla DL (2020) Visual image quality impacts circadian rhythm-related gene expression in retina and in choroid: a potential mechanism for ametropias. Invest Ophthalmol vis Sci 61(5):13. https://doi.org/10.1167/iovs.61.5.13
Summers JA, Harper AR, Feasley CL, Van-Der-Wel H, Byrum JN, Hermann M, West CM (2016) Identification of Apolipoprotein A-I as a retinoic acid-binding protein in the eye. J Biol Chem 291(36):18991–19005. https://doi.org/10.1074/jbc.M116.725523
Swiatczak B, Feldkaemper M, Schraermeyer U, Schaeffel F (2019) Demyelination and shrinkage of axons in the retinal nerve fiber layer in chickens developing deprivation myopia. Exp Eye Res 188:107783. https://doi.org/10.1016/j.exer.2019.107783
Sze YH, Zhao Q, Cheung JKW, Li KK, Tse DYY, To CH, Lam TC (2021) High-pH reversed-phase fractionated neural retina proteome of normal growing C57BL/6 mouse. Sci Data 8(1):27. https://doi.org/10.1038/s41597-021-00813-1
Tan J, Tong BD, Wu YJ, Xiong W (2014) MicroRNA-29 mediates TGFβ1-induced extracellular matrix synthesis by targeting wnt/β-catenin pathway in human orbital fibroblasts. Int J Clin Exp Pathol 7(11):7571–7577
Tanaka Y, Kurihara T, Hagiwara Y, Ikeda SI, Mori K, Jiang X, Torii H, Tsubota K (2019) Ocular-component-specific miRNA expression in a murine model of lens-induced myopia. Int J Mol Sci. https://doi.org/10.3390/ijms20153629
Tao Y, Pan M, Liu S, Fang F, Lu R, Lu C, Zheng M, An J, Xu H, Zhao F, Chen JF, Qu J, Zhou X (2013) cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. PLoS ONE 8(8):e71441. https://doi.org/10.1371/journal.pone.0071441
Tedja MS, Haarman AEG, Meester-Smoor MA, Kaprio J, Mackey DA, Guggenheim JA, Hammond CJ, Verhoeven VJM, Klaver CCW (2019) IMI - myopia genetics report. Invest Ophthalmol vis Sci 60(3):M89-m105. https://doi.org/10.1167/iovs.18-25965
Thomson K, Karouta C, Ashby R (2020) Form-deprivation and lens-induced myopia are similarly affected by pharmacological manipulation of the dopaminergic system in chicks. Invest Ophthalmol vis Sci 61(12):4. https://doi.org/10.1167/iovs.61.12.4
Thomson K, Kelly T, Karouta C, Morgan I, Ashby R (2021) Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release. Br J Pharmacol 178(22):4501–4517. https://doi.org/10.1111/bph.15629
Tian N, Copenhagen DR (2003) Visual stimulation is required for refinement of ON and OFF pathways in postnatal retina. Neuron 39(1):85–96. https://doi.org/10.1016/s0896-6273(03)00389-1
Tkatchenko AV, Walsh PA, Tkatchenko TV, Gustincich S, Raviola E (2006) Form deprivation modulates retinal neurogenesis in primate experimental myopia. Proc Natl Acad Sci U S A 103(12):4681–4686. https://doi.org/10.1073/pnas.0600589103
Tkatchenko AV, Tkatchenko TV, Guggenheim JA, Verhoeven VJ, Hysi PG, Wojciechowski R, Singh PK, Kumar A, Thinakaran G, Williams C (2015) APLP2 regulates refractive error and myopia development in mice and humans. PLoS Genet 11(8):e1005432. https://doi.org/10.1371/journal.pgen.1005432
Tkatchenko AV, Luo X, Tkatchenko TV, Vaz C, Tanavde VM, Maurer-Stroh S, Zauscher S, Gonzalez P, Young TL (2016) Large-Scale microRNA expression profiling identifies putative retinal miRNA-mRNA signaling pathways underlying form-deprivation myopia in mice. PLoS ONE 11(9):e0162541. https://doi.org/10.1371/journal.pone.0162541
Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y, Ohshima T (2019) Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s model mice. Genes Cells 24(1):31–40. https://doi.org/10.1111/gtc.12651
Tonouchi A, Nagai J, Togashi K, Goshima Y, Ohshima T (2016) Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson’s disease. J Neurochem 137(5):795–805. https://doi.org/10.1111/jnc.13617
Tosini G (2000) Melatonin circadian rhythm in the retina of mammals. Chronobiol Int 17(5):599–612. https://doi.org/10.1081/cbi-100101067
Tosini G, Menaker M (1998) The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration. Brain Res 789(2):221–228. https://doi.org/10.1016/s0006-8993(97)01446-7
Tosini G, Baba K, Hwang CK, Iuvone PM (2012) Melatonin: an underappreciated player in retinal physiology and pathophysiology. Exp Eye Res 103:82–89. https://doi.org/10.1016/j.exer.2012.08.009
Troilo D, Gottlieb MD, Wallman J (1987) Visual deprivation causes myopia in chicks with optic nerve section. Curr Eye Res 6(8):993–999. https://doi.org/10.3109/02713688709034870
Troilo D, Smith EL 3rd, Nickla DL, Ashby R, Tkatchenko AV, Ostrin LA, Gawne TJ, Pardue MT, Summers JA, Kee CS, Schroedl F, Wahl S, Jones L (2019) IMI - report on experimental models of emmetropization and myopia. Invest Ophthalmol vis Sci 60(3):M31-m88. https://doi.org/10.1167/iovs.18-25967
Upadhyay A, Beuerman RW (2020) Biological mechanisms of atropine control of myopia. Eye Contact Lens 46(3):129–135. https://doi.org/10.1097/icl.0000000000000677
van der Sande E, Haarman AEG, Quint WH, Tadema KCD, Meester-Smoor MA, Kamermans M, De Zeeuw CI, Klaver CCW, Winkelman BHJ, Iglesias AI (2022) The role of GJD2(Cx36) in refractive error development. Invest Ophthalmol vis Sci 63(3):5. https://doi.org/10.1167/iovs.63.3.5
Vancura P, Wolloscheck T, Baba K, Tosini G, Iuvone PM, Spessert R (2016) Circadian and dopaminergic regulation of fatty acid oxidation pathway genes in retina and photoreceptor cells. PLoS ONE 11(10):e0164665. https://doi.org/10.1371/journal.pone.0164665
Vocale LG, Crewther S, Riddell N, Hall NE, Murphy M, Crewther D (2021) RNA-seq and GSEA identifies suppression of ligand-gated chloride efflux channels as the major gene pathway contributing to form deprivation myopia. Sci Rep 11(1):5280. https://doi.org/10.1038/s41598-021-84338-y
Waldner DM, Giraldo Sierra NC, Bonfield S, Nguyen L, Dimopoulos IS, Sauvé Y, Stell WK, Bech-Hansen NT (2018) Cone dystrophy and ectopic synaptogenesis in a Cacna1f loss of function model of congenital stationary night blindness (CSNB2A). Channels (austin) 12(1):17–33. https://doi.org/10.1080/19336950.2017.1401688
Wallman J (1993) Retinal control of eye growth and refraction. Progress Retinal Res 12:133–153
Wang F, Zhou J, Lu Y, Chu R (2011) Effects of 530 nm green light on refractive status, melatonin, MT1 receptor, and melanopsin in the guinea pig. Curr Eye Res 36(2):103–111. https://doi.org/10.3109/02713683.2010.526750
Wang M, Aleman AC, Schaeffel F (2019) Probing the potency of artificial dynamic ON or OFF stimuli to inhibit myopia development. Invest Ophthalmol vis Sci 60(7):2599–2611. https://doi.org/10.1167/iovs.18-26471
Wang Q, Banerjee S, So C, Qiu C, Sze Y, Lam TC, To CH, Pan F (2021) The effect of low-dose atropine on alpha ganglion cell signaling in the mouse retina. Front Cell Neurosci 15:664491. https://doi.org/10.3389/fncel.2021.664491
Wei Y, Li N, Zhao L, Yang C, Ma B, Li X, Wei R, Nian H (2020) MicroRNAs and autoimmune-mediated eye diseases. Front Cell Dev Biol 8:818. https://doi.org/10.3389/fcell.2020.00818
Wiechmann AF, Summers JA (2008) Circadian rhythms in the eye: the physiological significance of melatonin receptors in ocular tissues. Prog Retin Eye Res 27(2):137–160. https://doi.org/10.1016/j.preteyeres.2007.10.001
Wisard J, Faulkner A, Chrenek MA, Waxweiler T, Waxweiler W, Donmoyer C, Liou GI, Craft CM, Schmid GF, Boatright JH, Pardue MT, Nickerson JM (2011) Exaggerated eye growth in IRBP-deficient mice in early development. Invest Ophthalmol vis Sci 52(8):5804–5811. https://doi.org/10.1167/iovs.10-7129
Witkovsky P (2004) Dopamine and retinal function. Doc Ophthalmol 108(1):17–40. https://doi.org/10.1023/b:doop.0000019487.88486.0a
Wojciechowski R (2011) Nature and nurture: the complex genetics of myopia and refractive error. Clin Genet 79(4):301–320. https://doi.org/10.1111/j.1399-0004.2010.01592.x
Wojciechowski R, Hysi PG (2013) Focusing in on the complex genetics of myopia. PLoS Genet 9(4):e1003442. https://doi.org/10.1371/journal.pgen.1003442
Wong TY, Ferreira A, Hughes R, Carter G, Mitchell P (2014) Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review. Am J Ophthalmol 157(1):9-25.e12. https://doi.org/10.1016/j.ajo.2013.08.010
Wu Q, Blakeley LR, Cornwall MC, Crouch RK, Wiggert BN, Koutalos Y (2007) Interphotoreceptor retinoid-binding protein is the physiologically relevant carrier that removes retinol from rod photoreceptor outer segments. Biochemistry 46(29):8669–8679. https://doi.org/10.1021/bi7004619
Wu XH, Li YY, Zhang PP, Qian KW, Ding JH, Hu G, Weng SJ, Yang XL, Zhong YM (2015) Unaltered retinal dopamine levels in a C57BL/6 mouse model of form-deprivation myopia. Invest Ophthalmol vis Sci 56(2):967–977. https://doi.org/10.1167/iovs.13-13362
Wu Y, Lam CS, Tse DY, To CH, Liu Q, McFadden SA, Chun RK, Li KK, Bian J, Lam C (2018) Early quantitative profiling of differential retinal protein expression in lens-induced myopia in guinea pig using fluorescence difference two-dimensional gel electrophoresis. Mol Med Rep 17(4):5571–5580. https://doi.org/10.3892/mmr.2018.8584
Wu PC, Chen CT, Chang LC, Niu YZ, Chen ML, Liao LL, Rose K, Morgan IG (2020a) Increased time outdoors is followed by reversal of the long-term trend to reduced visual acuity in Taiwan primary school students. Ophthalmology 127(11):1462–1469. https://doi.org/10.1016/j.ophtha.2020.01.054
Wu Y, Qiu J, Chen S, Chen X, Zhang J, Zhuang J, Liu S, Yang M, Zhou P, Chen H, Ge J, Yu K, Zhuang J (2020b) Crx is posttranscriptionally regulated by light stimulation in postnatal rat retina. Front Cell Dev Biol 8:174. https://doi.org/10.3389/fcell.2020.00174
Xie Y, Ouyang X, Wang G (2020) Mechanical strain affects collagen metabolism-related gene expression in scleral fibroblasts. Biomed Pharmacother 126:110095. https://doi.org/10.1016/j.biopha.2020.110095
Yang XL (2004) Characterization of receptors for glutamate and GABA in retinal neurons. Prog Neurobiol 73(2):127–150. https://doi.org/10.1016/j.pneurobio.2004.04.002
Yang JW, Xu YC, Sun L, Tian XD (2010) 5-hydroxytryptamine level and 5-HT2A receptor mRNA expression in the guinea pigs eyes with spectacle lens-induced myopia. Int J Ophthalmol 3(4):299–303. https://doi.org/10.3980/j.issn.2222-3959.2010.04.05
Yang J, Reinach PS, Zhang S, Pan M, Sun W, Liu B, Li F, Li X, Zhao A, Chen T, Jia W, Qu J, Zhou X (2017) Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs. Sci Rep 7(1):2777. https://doi.org/10.1038/s41598-017-03075-3
Yang C, Yao C, Tian R, Zhu Z, Zhao L, Li P, Chen H, Huang Y, Zhi E, Gong Y, Xue Y, Wang H, Yuan Q, He Z, Li Z (2019) miR-202-3p regulates sertoli cell proliferation, synthesis function, and apoptosis by targeting LRP6 and Cyclin D1 of Wnt/β-catenin signaling. Mol Ther Nucleic Acids 14:1–19. https://doi.org/10.1016/j.omtn.2018.10.012
Yin N, Yang YL, Cheng S, Wang HN, Hu X, Miao Y, Li F, Wang Z (2020) Dopamine D2 receptor-mediated modulation of rat retinal ganglion cell excitability. Neurosci Bull 36(3):230–242. https://doi.org/10.1007/s12264-019-00431-3
Yu FJ, Lam TC, Liu LQ, Chun RK, Cheung JK, Li KK, To CH (2017) Isotope-coded protein label based quantitative proteomic analysis reveals significant up-regulation of apolipoprotein A1 and ovotransferrin in the myopic chick vitreous. Sci Rep 7(1):12649. https://doi.org/10.1038/s41598-017-12650-7
Yu FJ, Lam TC, Sze AY, Li KK, Chun RK, Shan SW, To CH (2020) Alteration of retinal metabolism and oxidative stress may implicate myopic eye growth: Evidence from discovery and targeted proteomics in an animal model. J Proteomics 221:103684. https://doi.org/10.1016/j.jprot.2020.103684
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L (2019) Impaired mitochondrial fusion and oxidative phosphorylation triggered by high glucose is mediated by Tom22 in endothelial cells. Oxid Med Cell Longev 2019:4508762. https://doi.org/10.1155/2019/4508762
Zhang H, Wong CL, Shan SW, Li KK, Cheng AK, Lee KL, Ge J, To CH, Do CW (2011) Characterisation of Cl– transporter and channels in experimentally induced myopic chick eyes. Clin Exp Optom 94(6):528–535. https://doi.org/10.1111/j.1444-0938.2011.00611.x
Zhang Z, Li H, Liu X, O’Brien J, Ribelayga CP (2015) Circadian clock control of connexin36 phosphorylation in retinal photoreceptors of the CBA/CaJ mouse strain. Vis Neurosci 32:E009. https://doi.org/10.1017/s0952523815000061
Zhang Y, Hu DN, Zhu Y, Sun H, Gu P, Zhu D, Zhou J (2017) Regulation of matrix metalloproteinase-2 secretion from scleral fibroblasts and retinal pigment epithelial cells by miR-29a. Biomed Res Int 2017:2647879. https://doi.org/10.1155/2017/2647879
Zhang S, Yang J, Reinach PS, Wang F, Zhang L, Fan M, Ying H, Pan M, Qu J, Zhou X (2018) Dopamine receptor subtypes mediate opposing effects on form deprivation myopia in pigmented guinea pigs. Invest Ophthalmol vis Sci 59(11):4441–4448. https://doi.org/10.1167/iovs.17-21574
Zhao F, Li Q, Chen W, Zhu H, Zhou D, Reinach PS, Yang Z, He M, Xue A, Wu D, Liu T, Fu Q, Zeng C, Qu J, Zhou X (2020) Dysfunction of VIPR2 leads to myopia in humans and mice. J Med Genet. https://doi.org/10.1136/jmedgenet-2020-107220
Zheng W, Chen Y, Zhou X, Zhang X, Chen Y, Guan X, Mao J (2020) Regulation of retinal melanopsin on lens-induced myopia in guinea pigs. Optom vis Sci 97(7):489–495. https://doi.org/10.1097/opx.0000000000001529
Zhong X, Ge J, Smith EL 3rd, Stell WK (2004) Image defocus modulates activity of bipolar and amacrine cells in macaque retina. Invest Ophthalmol vis Sci 45(7):2065–2074. https://doi.org/10.1167/iovs.03-1046
Zhou X, Pardue MT, Iuvone PM, Qu J (2017) Dopamine signaling and myopia development: What are the key challenges. Prog Retin Eye Res 61:60–71. https://doi.org/10.1016/j.preteyeres.2017.06.003
Zhou YY, Chun RKM, Wang JC, Zuo B, Li KK, Lam TC, Liu Q, To CH (2018) Proteomic analysis of chick retina during early recovery from lens-induced myopia. Mol Med Rep 18(1):59–66. https://doi.org/10.3892/mmr.2018.8954
Zhou X, Zhang R, Zhang S, Wu J, Sun X (2019) Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma. J Neurosci 39(8):1484–1504. https://doi.org/10.1523/jneurosci.1685-18.2018
Zhou X, Zhang S, Zhang G, Chen Y, Lei Y, Xiang J, Xu R, Qu J, Zhou X (2020) Increased choroidal blood perfusion can inhibit form deprivation myopia in guinea pigs. Invest Ophthalmol vis Sci 61(13):25. https://doi.org/10.1167/iovs.61.13.25
Zhou, Xiangtian, Xiong, Weiwei, Huang, Furong, Yang, JInglei, Qu, Jia (2014) C57BL/6 mouse eyes treated by dopamine D1 receptor agonist and antagonist during form deprivation: an opposite effect on axial length and refractive development. Arvo Meeting Abstracts. 55(5).
Zhu X, Wallman J (2009) Opposite effects of glucagon and insulin on compensation for spectacle lenses in chicks. Invest Ophthalmol vis Sci 50(1):24–36. https://doi.org/10.1167/iovs.08-1708
Zhu Y, Bian JF, Lu DQ, To CH, Lam CS, Li KK, Yu FJ, Gong BT, Wang Q, Ji XW, Zhang HM, Nian H, Lam TC, Wei RH (2022) Alteration of EIF2 signaling, glycolysis, and dopamine secretion in form-deprived myopia in response to 1% atropine treatment: evidence from interactive iTRAQ-MS and SWATH-MS proteomics using a guinea pig model. Front Pharmacol 13:814814. https://doi.org/10.3389/fphar.2022.814814
Zou H, Ding Y, Wang K, Xiong E, Peng W, Du F, Zhang Z, Liu J, Gong A (2015) MicroRNA-29A/PTEN pathway modulates neurite outgrowth in PC12 cells. Neuroscience 291:289–300. https://doi.org/10.1016/j.neuroscience.2015.01.055
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Huang, Y., Chen, X., Zhuang, J. et al. The Role of Retinal Dysfunction in Myopia Development. Cell Mol Neurobiol 43, 1905–1930 (2023). https://doi.org/10.1007/s10571-022-01309-1
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DOI: https://doi.org/10.1007/s10571-022-01309-1