Abstract
The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix −/− mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.
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Acknowledgements
We thank Kathleen Cato for technical assistance and Rowan Tweedale and Linda Richards for critical analysis of the manuscript. This work was funded by the National Health and Medical Research Council (NHMRC) Project Grants (Grant Numbers 1022308, 1003462; MP) and by awards from the NYSTEM (C026429; RMG) and the NIH (HL 080624; RMG). MP was supported by an Australian Research Council Future Fellowship.
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The authors declare that they have no conflicts of interest.
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Chantelle Dixon and Tracey J. Harvey have contributed equally to this work.
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Dixon, C., Harvey, T.J., Smith, A.G. et al. Nuclear Factor One X Regulates Bobby Sox During Development of the Mouse Forebrain. Cell Mol Neurobiol 33, 867–873 (2013). https://doi.org/10.1007/s10571-013-9961-4
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DOI: https://doi.org/10.1007/s10571-013-9961-4