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HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex

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Abstract.

The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates Cdc10-dependent transcription at G1/S and allows growth of cdc10-129, res1 Δ and rep2 Δ mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.

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Authors and Affiliations

  1. Instituto de Microbiología Bioquímica, Departamento de Microbiología y Genética, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain, , , , ,

    Alberto Sánchez-Díaz, Miguel Blanco & Sergio Moreno

  2. The Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK, , , , ,

    Nic Jones

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  1. Alberto Sánchez-Díaz
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  2. Miguel Blanco
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  3. Nic Jones
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  4. Sergio Moreno
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Sánchez-Díaz, A., Blanco, M., Jones, N. et al. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. Curr Genet 40, 110–118 (2001). https://doi.org/10.1007/s002940100241

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  • DOI: https://doi.org/10.1007/s002940100241

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