Abstract
In this study, novel cellulose/carboxymethyl chitosan (CMCS) composite hydrogels were prepared by blending cellulose and CMCS in LiOH/urea aqueous solutions, and then cross-linking with epichlorohydrin. The structure and morphology of the composite hydrogels were characterized by Fourier transform infrared spectroscopy, wide-angle x-ray diffraction, thermo-gravimetric analysis, and scanning electron microscopy. The results revealed that chemical cross-linking reaction between cellulose and CMCS occurred in the hydrogel. Moreover, CMCS contributed to the enhancement of pore size, whereas cellulose acted as a strong backbone in the hydrogel to support the pore wall. The compressive strength of the composite hydrogels was significantly improved from 39.2 ± 2.2 to 145.2 ± 2.8 kPa as a result of the increase in cellulose content, while the equilibrium swelling ratio increased rapidly from 33.8 to 154.2 g/g with the increase in CMCS content. The composite hydrogels showed no cytotoxicity towards L929 cells, suggesting good biocompatibility. All these results indicate that the proposed cellulose/CMCS composite hydrogels can be effectively used as wound dressing materials.
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Acknowledgments
This work was supported by open fund of State Key Laboratory of Bio-Fibers and Eco-Textiles (Qingdao University, No. KF2020205) as well as Scientific Research Programme of Hubei Provincial Department of Education (No. Q20171608). The authors gratefully thank Laboratory of Natural polymer and Polymer Physics (Wuhan University) for assistance with testing cytotoxicity.
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Guo, Y., Zhao, C., Yan, C. et al. Construction of cellulose/carboxymethyl chitosan hydrogels for potential wound dressing application. Cellulose 28, 10013–10023 (2021). https://doi.org/10.1007/s10570-021-04149-2
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DOI: https://doi.org/10.1007/s10570-021-04149-2