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Controlled in situ graft polymerization of DMAEMA onto cotton surface via SI-ARGET ATRP for low-adherent wound dressings

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Abstract

Traditional wound dressings such as cotton gauze and bandages are adhesive and often painful to detach from wounded skin, leading to additional damage to the wound. It is essential to develop low-adherent wound dressings for relief of pain and trauma in the wound healing process. In this work, a new methodology based on surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (SI-ARGET ATRP) was employed to fabricate hybrid cotton–hydrogel dressings via direct polymerization of poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) hydrogel on the surface of cotton fibers. The chemical structure, hydrophilicity, peeling energy, stiffness, and cell adhesion behavior of the hybrid dressings were investigated to elucidate the relationship between their surface structure and properties. The resulting hybrid dressings exhibited good biocompatibility, excellent mechanical strength, and low adhesion, and provided a favorable environment to promote wound healing. These results suggest that low-adherent hybrid dressings can be obtained by grafting hydrogels, having great potential for use in wound care.

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References

  • Asghari S, Logsetty S, Liu S (2016) Imparting commercial antimicrobial dressings with low-adherence to burn wounds. Burns 42:877–883

    Article  Google Scholar 

  • Ataollahi F, Pramanik S, Moradi A, Dalilottojari A, Pingguan-Murphy B, Abas W, Bakar WA, Osman A, Azuan N (2015) Endothelial cell responses in terms of adhesion, proliferation, and morphology to stiffness of polydimethylsiloxane elastomer substrates. J Biomed Mater Res A 103:2203–2213

    Article  CAS  Google Scholar 

  • Barbey R, Lavanant L, Paripovic D, Schüwer N, Sugnaux C, Tugulu S, Klok H-A (2009) Polymer brushes via surface-initiated controlled radical polymerization: synthesis, characterization, properties, and applications. Chem Rev 109:5437–5527

    Article  CAS  Google Scholar 

  • Bütün V, Armes S, Billingham N (2001) Synthesis and aqueous solution properties of near-monodisperse tertiary amine methacrylate homopolymers and diblock copolymers. Polymer 42:5993–6008

    Article  Google Scholar 

  • Cai N, Hou D, Luo X, Han C, Fu J, Zeng H, Yu F (2016) Enhancing mechanical properties of polyelectrolyte complex nanofibers with graphene oxide nanofillers pretreated by polycation. Compos Sci Technol 135:128–136

    Article  CAS  Google Scholar 

  • Caló E, Khutoryanskiy VV (2015) Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J 65:252–267

    Article  Google Scholar 

  • Cao Z, Luo X, Zhang H, Fu Z, Shen Z, Cai N, Xue Y, Yu F (2016) A facile and green strategy for the preparation of porous chitosan-coated cellulose composite membranes for potential applications as wound dressing. Cellulose 23:1349–1361

    Article  CAS  Google Scholar 

  • Chang H, Zhang H, Hu M, Chen J-Y, Li B-C, Ren K-F, Martins MCL, Barbosa MA, Ji J (2017) Stiffness of polyelectrolyte multilayer film influences endothelial function of endothelial cell monolayer. Colloids Surf B Biointerfaces 149:379–387

    Article  CAS  Google Scholar 

  • Croisier F, Atanasova G, Poumay Y, Jérôme C (2014) Polysaccharide-coated PCL nanofibers for wound dressing applications. Adv Healthc Mater 3:2032–2039

    Article  CAS  Google Scholar 

  • Czaja WK, Young DJ, Kawecki M, Brown RM (2007) The future prospects of microbial cellulose in biomedical applications. Biomacromolecules 8:1–12

    Article  CAS  Google Scholar 

  • Deng J, Wang L, Liu L, Yang W (2009) Developments and new applications of UV-induced surface graft polymerizations. Prog Polym Sci 34:156–193

    Article  CAS  Google Scholar 

  • Deng B, Cai R, Yu Y, Jiang H, Wang C, Li J, Li L, Yu M, Li J, Xie L (2010) Laundering durability of superhydrophobic cotton fabric. Adv Mater 22:5473–5477

    Article  CAS  Google Scholar 

  • Discher DE, Janmey P, Wang Y-L (2005) Tissue cells feel and respond to the stiffness of their substrate. Science 310:1139–1143

    Article  CAS  Google Scholar 

  • Dong X, Bao H, Ou K, Yao J, Zhang W, He J (2015) Polymer-grafted modification of cotton fabrics by SI-ARGET ATRP. Fiber Polym 16:1478–1486

    Article  CAS  Google Scholar 

  • Edmondson S, Osborne VL, Huck WT (2004) Polymer brushes via surface-initiated polymerizations. Chem Soc Rev 33:14–22

    Article  CAS  Google Scholar 

  • Engler AJ, Sen S, Sweeney HL, Discher DE (2006) Matrix elasticity directs stem cell lineage specification. Cell 126:677–689

    Article  CAS  Google Scholar 

  • Ferrero F, Periolatto M (2013) Application of fluorinated compounds to cotton fabrics via sol-gel. Appl Surf Sci 275:201–207

    Article  CAS  Google Scholar 

  • Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008) Wound repair and regeneration. Nature 453:314–321

    Article  CAS  Google Scholar 

  • Hashemi Doulabi A, Mirzadeh H, Imani M, Samadi N (2013) Chitosan/polyethylene glycol fumarate blend film: Physical and antibacterial properties. Carbohydr Polym 92:48–56

    Article  CAS  Google Scholar 

  • Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deilv Rev 64:18–23

    Article  Google Scholar 

  • Hrynyk M, Martins-Green M, Barron AE, Neufeld RJ (2012) Alginate-PEG sponge architecture and role in the design of insulin release dressings. Biomacromolecules 13:1478–1485

    Article  CAS  Google Scholar 

  • Huang K-T, Fang Y-L, Hsieh P-S, Li C-C, Dai N-T, Huang C-J (2016) Zwitterionic nanocomposite hydrogels as effective wound dressings. J Mater Chem B 4:4206–4215

    Article  CAS  Google Scholar 

  • Jakubowski W, Min K, Matyjaszewski K (2006) Activators regenerated by electron transfer for atom transfer radical polymerization of styrene. Macromolecules 39:39–45

    Article  CAS  Google Scholar 

  • Jhong J-F, Venault A, Hou C-C, Chen S-H, Wei T-C, Zheng J, Huang J, Chang Y (2013) Surface zwitterionization of expanded poly (tetrafluoroethylene) membranes via atmospheric plasma-induced polymerization for enhanced skin wound healing. ACS Appl Mater Interfaces 5:6732–6742

    Article  CAS  Google Scholar 

  • Lalani R, Liu L (2012) Electrospun zwitterionic poly(sulfobetaine methacrylate) for nonadherent, superabsorbent, and antimicrobial wound dressing applications. Biomacromolecules 13:1853–1863

    Article  CAS  Google Scholar 

  • Li L, Wang N, Jin X, Deng R, Nie S, Sun L, Wu Q, Wei Y, Gong C (2014) Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention. Biomaterials 35:3903–3917

    Article  CAS  Google Scholar 

  • Li Y, Jiang H, Zheng W, Gong N, Chen L, Jiang X, Yang G (2015) Bacterial cellulose-hyaluronan nanocomposite biomaterials as wound dressings for severe skin injury repair. J Mater Chem B 3:3498–3507

    Article  CAS  Google Scholar 

  • Lin W-C, Lien C-C, Yeh H-J, Yu C-M, Hsu S-H (2013) Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications. Carbohydr Polym 94:603–611

    Article  CAS  Google Scholar 

  • Luna-Straffon MA, Contreras-García A, Brackman G, Coenye T, Concheiro A, Alvarez-Lorenzo C, Bucio E (2014) Wound debridement and antibiofilm properties of gamma-ray DMAEMA-grafted onto cotton gauzes. Cellulose 21:3767–3779

    Article  CAS  Google Scholar 

  • Martin P (1997) Wound healing–aiming for perfect skin regeneration. Science 276:75–81

    Article  CAS  Google Scholar 

  • Meftahi A, Khajavi R, Rashidi A, Sattari M, Yazdanshenas M, Torabi M (2010) The effects of cotton gauze coating with microbial cellulose. Cellulose 17:199–204

    Article  CAS  Google Scholar 

  • Müller FA, Müller L, Hofmann I, Greil P, Wenzel MM, Staudenmaier R (2006) Cellulose-based scaffold materials for cartilage tissue engineering. Biomaterials 27:3955–3963

    Article  Google Scholar 

  • Ning CC, Logsetty S, Ghughare S, Liu S (2014) Effect of hydrogel grafting, water and surfactant wetting on the adherence of PET wound dressings. Burns 40:1164–1171

    Article  Google Scholar 

  • Norouzi M, Afrasiabi Garekani A (2014) Corrosion protection by zirconia-based thin films deposited by a sol–gel spin coating method. Ceram Int 40:2857–2861

    Article  CAS  Google Scholar 

  • Oliveira MAM, Boyer C, Nele M, Pinto JC, Zetterlund PB, Davis TP (2011) Synthesis of biodegradable hydrogel nanoparticles for bioapplications using inverse miniemulsion RAFT polymerization. Macromolecules 44:7167–7175

    Article  CAS  Google Scholar 

  • Ou K, Dong X, Qin C, Ji X, He J (2017) Properties and toughening mechanisms of PVA/PAM double-network hydrogels prepared by freeze-thawing and anneal-swelling. Mater Sci Eng C 77:1017–1026

    Article  CAS  Google Scholar 

  • Pakdel E, Daoud WA, Sun L, Wang X (2014) Visible and UV functionality of TiO2 ternary nanocomposites on cotton. Appl Surf Sci 321:447–456

    Article  CAS  Google Scholar 

  • Peng X-W, Ren J-L, Zhong L-X, Sun R-C (2011) Nanocomposite films based on xylan-rich hemicelluloses and cellulose nanofibers with enhanced mechanical properties. Biomacromolecules 12:3321–3329

    Article  CAS  Google Scholar 

  • Pereira R, Carvalho A, Vaz DC, Gil M, Mendes A, Bártolo P (2013) Development of novel alginate based hydrogel films for wound healing applications. Int J Biol Macromol 52:221–230

    Article  CAS  Google Scholar 

  • Perera S, Bhushan B, Bandara R, Rajapakse G, Rajapakse S, Bandara C (2013) Morphological, antimicrobial, durability, and physical properties of untreated and treated textiles using silver-nanoparticles. Colloids Surf Physicochem Eng Aspects 436:975–989

    Article  CAS  Google Scholar 

  • Pour SN, Ghugare SV, Wiens R, Gough K, Liu S (2015) Controlled in situ formation of polyacrylamide hydrogel on PET surface via SI-ARGET-ATRP for wound dressings. Appl Surf Sci 349:695–704

    Article  Google Scholar 

  • Ruckenstein E, Li Z (2005) Surface modification and functionalization through the self-assembled monolayer and graft polymerization. Adv Colloid Interface Sci 113:43–63

    Article  CAS  Google Scholar 

  • Sikareepaisan P, Ruktanonchai U, Supaphol P (2011) Preparation and characterization of asiaticoside-loaded alginate films and their potential for use as effectual wound dressings. Carbohydr Polym 83:1457–1469

    Article  CAS  Google Scholar 

  • Simakova A, Averick SE, Konkolewicz D, Matyjaszewski K (2012) Aqueous ARGET ATRP. Macromolecules 45:6371–6379

    Article  CAS  Google Scholar 

  • Tissera ND, Wijesena RN, Perera JR, de Silva KN, Amaratunge GA (2015) Hydrophobic cotton textile surfaces using an amphiphilic graphene oxide (GO) coating. Appl Surf Sci 324:455–463

    Article  CAS  Google Scholar 

  • Ullah H, Santos HA, Khan T (2016) Applications of bacterial cellulose in food, cosmetics and drug delivery. Cellulose 23:2291–2314

    Article  CAS  Google Scholar 

  • Villa-Diaz LG, Nandivada H, Ding J, Nogueira-de-Souza NC, Krebsbach PH, O’shea KS, Lahann J, Smith GD (2010) Synthetic polymer coatings for long-term growth of human embryonic stem cells. Nat Biotechnol 28:581–583

    Article  CAS  Google Scholar 

  • Wang J-Y, Wang K, Gu X, Luo Y (2016) Polymerization of hydrogel network on microfiber surface: synthesis of hybrid water-absorbing matrices for biomedical applications. ACS Biomater Sci Eng 2:887–892

    Article  CAS  Google Scholar 

  • Wells RG (2008) The role of matrix stiffness in regulating cell behavior. Hepatology 47:1394–1400

    Article  CAS  Google Scholar 

  • Winter GD (1962) Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 193:293–294

    Article  CAS  Google Scholar 

  • Worthley CH, Constantopoulos KT, Ginic-Markovic M, Pillar RJ, Matisons JG, Clarke S (2011) Surface modification of commercial cellulose acetate membranes using surface-initiated polymerization of 2-hydroxyethyl methacrylate to improve membrane surface biofouling resistance. J Membr Sci 385:30–39

    Article  Google Scholar 

  • Xu F, Zhong S, Yung L, Kang E, Neoh K (2004) Surface-active and stimuli-responsive polymer-Si (100) hybrids from surface-initiated atom transfer radical polymerization for control of cell adhesion. Biomacromolecules 5:2392–2403

    Article  CAS  Google Scholar 

  • Yeh Y-T, Hur SS, Chang J, Wang K-C, Chiu J-J, Li Y-S, Chien S (2012) Matrix stiffness regulates endothelial cell proliferation through septin 9. PLoS ONE 7:e46889

    Article  CAS  Google Scholar 

  • Zahedi P, Rezaeian I, Ranaei-Siadat SO, Jafari SH, Supaphol P (2010) A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym Adv Technol 21:77–95

    Article  CAS  Google Scholar 

  • Zhang J, Li B, Wu L, Wang A (2013) Facile preparation of durable and robust superhydrophobic textiles by dip coating in nanocomposite solution of organosilanes. Chem Commun 49:11509–11511

    Article  CAS  Google Scholar 

  • Zhu Y, Zhang J, Yang J, Pan C, Xu T, Zhang L (2016) Zwitterionic hydrogels promote skin wound healing. J Mater Chem B 4:5105–5111

    Article  CAS  Google Scholar 

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Acknowledgments

This research was financially supported by the National Natural Science Foundation of China (21303013) and the Ph.D. Foundation for Innovation of Donghua University (CUSF-DH-D-2016022).

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  1. Kangkang Ou and Xiaojin Wu contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

    Kangkang Ou, Chen Meng, Xia Dong & Jinxin He

  2. Department of Dermatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Xiaojin Wu

  3. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China

    Baoxiu Wang

  4. Key Laboratory of Textile Science and Technology, Ministry of Education, Shanghai, 201620, China

    Jinxin He

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  1. Kangkang Ou
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Correspondence to Xia Dong or Jinxin He.

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Ou, K., Wu, X., Wang, B. et al. Controlled in situ graft polymerization of DMAEMA onto cotton surface via SI-ARGET ATRP for low-adherent wound dressings. Cellulose 24, 5211–5224 (2017). https://doi.org/10.1007/s10570-017-1449-9

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