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KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?

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Abstract

Present therapeutic approaches do not effectively target metastatic cancers, often limited by their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy-resistant tumor cells. Devising effective approaches targeting dormant tumor cells has been a focus of cancer clinicians for decades. However, progress has been limited due to limited understanding of the tumor dormancy process. Studies on tumor dormancy have picked up pace and have resulted in the identification of several regulators. This review focuses on KISS1, a metastasis suppressor gene that suppresses metastasis by keeping tumor cells in a state of dormancy at ectopic sites. The review explores mechanistic insights of KISS1 and discusses its potential application as a therapeutic against metastatic cancers by eliminating quiescent cells or inducing long-term dormancy in tumor cells.

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Acknowledgements

Work done in SH’s lab has been generously funded by a grant from Indian Council of Medical Research (ICMR-2021-8665-F1). Work done in DRW’s lab has been generously funded by grants from the U.S. National Cancer Institute (RO1-CA62168; P30-CA168524), the National Foundation for Cancer Research, METAvivor Research and Services Inc., and Theresa’s Research Foundation. We apologize to any authors whose work was omitted due to article guidelines.

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  1. Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India

    Sitaram Harihar

  2. Department of Cancer Biology, The Kansas University Medical Center, Kansas City, USA

    Danny R. Welch

  3. The University of Kansas Comprehensive Cancer Center, 3901 Rainbow Blvd. Kansas City, Kansas City, KS, 66160, USA

    Danny R. Welch

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Harihar, S., Welch, D.R. KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?. Cancer Metastasis Rev 42, 183–196 (2023). https://doi.org/10.1007/s10555-023-10090-6

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