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Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology

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Abstract

The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first discovered in 1993, and studies pursued thereafter attributed a potential tumour-suppressive function to the enzyme. In recent years, however, further functional characterization of the tyrosine kinase in diverse cancer types suggests that FRK may potentially play an oncogenic role as well. Specifically, while ectopic expression of FRK suppresses cell proliferation and migration in breast and brain cancers, knockdown or catalytic inhibition of FRK suppresses these cellular processes in pancreatic and liver cancer. Such functional paradox is therefore evidently exhibited in a tissue-specific context. This review sheds light on the recent developments emerged from investigations on FRK which include: (a) a review of the expression pattern of the protein in mammalian cells/tissues, (b) underlying genomic perturbations and (c) a mechanistic function of the enzyme across different cellular environments. Given its functional heterogeneity observed across different cancers, we also discuss the therapeutic significance of FRK.

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Acknowledgments

The authors apologize to those whose work was not included owing to space limitations. Breast cancer research in the Lukong lab is supported over the years by funds from various organizations including the Canadian Breast Cancer Foundation (CBCF) and Canadian Institutes of Health Research (CIHR).

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  1. Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Health Sciences Building, Saskatoon, S7N 5E5, Saskatchewan, Canada

    Raghuveera Kumar Goel & Kiven Erique Lukong

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  1. Raghuveera Kumar Goel
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  2. Kiven Erique Lukong
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Correspondence to Kiven Erique Lukong.

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Goel, R.K., Lukong, K.E. Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology. Cancer Metastasis Rev 35, 179–199 (2016). https://doi.org/10.1007/s10555-016-9623-3

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  • DOI: https://doi.org/10.1007/s10555-016-9623-3

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