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Central and peripheral nervous systems: master controllers in cancer metastasis

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Abstract

Central and sympathetic nervous systems govern functional activities of many organs. Solid tumors like organs are also innervated by sympathetic nerve fibers. Neurotransmitters released from sympathetic nerve fibers can modulate biological behaviors of tumor cells. Multiple physiologic processes of tumor development may be dominated by central and sympathetic nervous systems as well. Recent studies suggest that dysfunction of central and sympathetic nervous systems and disorder of the hormone network induced by psychological stress may influence malignant progression of cancer by inhibiting the functions of immune system, regulating metabolic reprogramming of tumor cells, and inducing interactions between tumor and stromal cells. Over-release of inflammatory cytokines by tumors may aggravate emotional disorder, triggering the vicious cycles in tumor microenvironment and host macroenvironment. It is reasonable to hypothesize that cancer progression may be controlled by central and sympathetic nervous systems. In this review, we will focus on the recent information about the impacts of central and sympathetic nervous systems on tumor invasion and metastasis.

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Acknowledgments

This work is supported by the National Basic Research Program of China (973 program, no. 2010CB911904), National Natural Science Foundation of China (no. 30901766 and 30972690 and 30800582), and Beijing Natural Science Foundation (no. 7122124 and 7132163).

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  1. Department of Pathophysiology, Institute of Basic Medical Sciences, Beijing, 100850, China

    Ming Shi, Dan Liu, Zhengyan Yang & Ning Guo

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  1. Ming Shi
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Correspondence to Ming Shi or Ning Guo.

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Shi, M., Liu, D., Yang, Z. et al. Central and peripheral nervous systems: master controllers in cancer metastasis. Cancer Metastasis Rev 32, 603–621 (2013). https://doi.org/10.1007/s10555-013-9440-x

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