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The consistency of myocardial strain derived from heart deformation analysis

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Abstract

The purpose of this study was to assess the consistency of semi-automated myocardial strain analysis by prototype software across field strengths, temporal resolutions, and examinations. 35 volunteers (48 ± 13 years; 20% women) and 25 patients (54 ± 12 years; 44% women) without significant cardiac dysfunction underwent cine cardiac magnetic resonance imaging (CMR) at 1.5 T with a temporal resolution of 39.2 msec. 34 subjects also underwent imaging at 3.0 T; 16 had repeat examinations within 14 days; and 9 underwent CMR with temporal resolutions of 12.5 and 39.2 msec on the same day. Prototype heart deformation analysis (HDA) software was used to retrospectively quantify strain from segmented balanced steady state free precession (bSSFP) cinegraphic images. Myocardial contours were automatically generated on short axis images and drawn at end-diastole by two independent reviewers on long-axis images. Contours were automatically propagated throughout the cardiac cycle. Global and regional peak systolic strain were compared across observers, field strengths, temporal resolutions, and examinations. Inter-observer agreement was excellent (ICC > 0.87, p < 0.01). Inter-examination variability was low, ranging from 1.7 (1.0–2.4)% to 2.5 (1.9–3.1)%, except for radial strain: 9.2 (7.6–10.5)%. Most global and regional strain values were not significantly different across field strengths and temporal resolutions (p > 0.05). Normal global peak systolic strain values with HDA were −25.0 (−24.0 to −26.1)% (LV circumferential), 60.5 (55.3 to 65.6)% (LV radial), −22.3 (−20.5 to − 24.0)% (LV longitudinal), and −26.0 (−23.8 to −28.2)% (RV longitudinal). HDA prototype software enabled efficient and consistent quantification of myocardial strain from conventional bSSFP cine CMR data, demonstrating clinical feasibility.

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Acknowledgements

The authors would like to thank Marisol Bello, Griselda Herrera, and Rebecca Ditch for their support coordinating and acquiring the MR imaging for this study.

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Authors and Affiliations

  1. Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Ave Suite 1600, Chicago, IL, USA

    Eric J. Keller, Shanna Fang, Kai Lin, Peter M. Smith, Rachel Davids, Maria Carr, Michael Markl, James C. Carr & Jeremy D. Collins

  2. Department of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Benjamin H. Freed

  3. Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, USA

    Bruce S. Spottiswoode

  4. Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ, USA

    Marie-Pierre Jolly

  5. Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA

    Michael Markl

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  1. Eric J. Keller
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Correspondence to Jeremy D. Collins.

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Conflict of interest

Authors MPJ and BSS are full-time employees of Siemens Medical Solutions USA, Inc. No other authors have conflicts of interest relevant to this investigation.

Ethical approval

All procedures performed in accordance with the ethical standards of an Institutional Review Board (STU: 00074604) and 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all prospectively recruited volunteers and waived for retrospective review of patient data.

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Keller, E.J., Fang, S., Lin, K. et al. The consistency of myocardial strain derived from heart deformation analysis. Int J Cardiovasc Imaging 33, 1169–1177 (2017). https://doi.org/10.1007/s10554-017-1090-6

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  • DOI: https://doi.org/10.1007/s10554-017-1090-6

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