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Heart deformation analysis: measuring regional myocardial velocity with MR imaging

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Abstract

The aim of the present study was to test the hypothesis that heart deformation analysis (HDA) may serve as an alternative for the quantification of regional myocardial velocity. Nineteen healthy volunteers (14 male and 5 female) without documented cardiovascular diseases were recruited following the approval of the institutional review board (IRB). For each participant, cine images (at base, mid and apex levels of the left ventricle [LV]) and tissue phase mapping (TPM, at same short-axis slices of the LV) were acquired within a single magnetic resonance (MR) scan. Regional myocardial velocities in radial and circumferential directions acquired with HDA (Vrr and Vcc) and TPM (Vr and VФ) were measured during the cardiac cycle. HDA required shorter processing time compared to TPM (2.3 ± 1.1 min/case vs. 9.5 ± 3.7 min/case, p < 0.001). Moderate to good correlations between velocity components measured with HDA and TPM could be found on multiple myocardial segments (r = 0.460–0.774) and slices (r = 0.409–0.814) with statistical significance (p < 0.05). However, significant biases of velocity measures at regional myocardial areas between HDA and TPM were also noticed. By providing comparable velocity measures as TPM does, HDA may serve as an alternative for measuring regional myocardial velocity with a faster image processing procedure.

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Abbreviations

HDA:

Heart deformation analysis

TPM:

Tissue phase mapping

MRI:

Magnetic resonance imaging

Vrr:

HDA-derived radial velocity

Vcc:

HDA-derived circumferential velocity

Vr:

TPM-derived radial velocity

VФ:

TPM-derived circumferential velocity

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Acknowledgments

This study was supported by two grants from the National Institute of Health (R01HL117888 and K01HL121162).

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Authors and Affiliations

  1. Department of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA

    Kai Lin, Jeremy D. Collins, Varun Chowdhary, Michael Markl & James C. Carr

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  1. Kai Lin
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  2. Jeremy D. Collins
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  3. Varun Chowdhary
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  4. Michael Markl
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Correspondence to Kai Lin.

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Ethical approval

All procedures performed in studies were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The IRM approved this study.

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Written informed consent was obtained from all individual participants included in the study.

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Lin, K., Collins, J.D., Chowdhary, V. et al. Heart deformation analysis: measuring regional myocardial velocity with MR imaging. Int J Cardiovasc Imaging 32, 1103–1111 (2016). https://doi.org/10.1007/s10554-016-0879-z

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  • DOI: https://doi.org/10.1007/s10554-016-0879-z

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