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Independent association between brachial-ankle pulse wave velocity and global longitudinal strain of left ventricle

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Abstract

Data regarding the influence of arterial stiffness on left ventricular (LV) long-axis function has been scarce. This study was performed to investigate the association between brachial-ankle pulse wave velocity (baPWV) and LV global longitudinal strain (GLS). A total of 248 subjects (mean age 59.2 ± 12.3 years; 50 % were men) without structural heart problems were retrospectively evaluated. LV GLS was measured by 2-dimensional speckle-tracking echocardiography. baPWV measurements were made on the same day of echocardiography. The incidences of hypertension, diabetes mellitus, and dyslipidemia were 51.2, 19.4, and 22.2 %, respectively. The mean value of baPWV was 1557 ± 285 cm/s. In simple linear regression analysis, baPWV had a significant positive association with LV GLS (β = 0.215, P = 0.001). In multiple linear regression analysis, baPWV was independently associated with LV GLS even after controlling for potential confounders, including age, gender, body mass index, systolic blood pressure, heart rate, HbA1c, total cholesterol, estimated glomerular filtration rate, left ventricular mass index, E/A, septal e′ velocity and pulmonary artery systolic pressure (β = 0.211, P = 0.028). The results of this study suggest that baPWV may be independently associated with LV GLS, supporting the evidence of a close interaction between arterial stiffness and LV function. Increased arterial stiffness may result in impaired LV longitudinal function.

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Acknowledgments

The authors appreciate the help of Seon Kyung Lee, Min-Seon Choi, Yu Nui Gim, and Hye Jin Park with data collection.

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Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, 39 Boramae-gil, Dongjak-gu, Seoul, 156-707, Korea

    Hack-Lyoung Kim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim & Joo-Hee Zo

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  1. Hack-Lyoung Kim
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  2. Jae-Bin Seo
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Correspondence to Joo-Hee Zo.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of Boramae Medical Center (Seoul, Korea) with the 2008 Helsinki declaration.

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Informed consent was waived by Institutional Review Board of Boramae Medical Center (Seoul, Korea) due to retrospective study design.

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Kim, HL., Seo, JB., Chung, WY. et al. Independent association between brachial-ankle pulse wave velocity and global longitudinal strain of left ventricle. Int J Cardiovasc Imaging 31, 1563–1570 (2015). https://doi.org/10.1007/s10554-015-0744-5

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  • DOI: https://doi.org/10.1007/s10554-015-0744-5

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