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Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging

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Abstract

A low level of high-density lipoprotein cholesterol (HDL-C) is a risk factor for atherosclerotic disease. Magnetic resonance imaging (MRI) can provide detailed information on carotid atherosclerotic plaque size and composition. The purpose of this study was to correlate HDL levels with carotid plaque burden and composition by MRI. Thirty-four patients with coronary artery disease (CAD) receiving simvastatin plus niacin or placebo for both drugs for three years were randomly selected to undergo MRI of carotid arteries. Atherosclerotic plaque wall volumes (WVs) and plaque components including lipid rich/necrotic core (LR/NC), calcium, fibrous tissue, and loose matrix were measured. Mean WV or atherosclerotic burden was significantly associated with total HDL-C levels (r = −0.39, P = 0.02), HDL2 (r = −0.36, P = 0.03), HDL3 (r = −0.34, P = 0.04), and LDL/HDL ratio (r = 0.42, P = 0.02). Plaque lipid composition or LR/NC was significantly associated with HDL3 (r = −0.68, P = 0.02). Patients with low HDL levels (≤35 mg/dL) had increased WV (97 ± 23 vs. 81 ± 19 mm3, P = 0.05) compared with patients with HDL levels > 35 mg/dL. Among CAD patients, low HDL-C levels were significantly associated with increased carotid atherosclerotic plaque burden and lipid content by MRI.

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References

  1. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA (1989) High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 79:8–15

    PubMed  CAS  Google Scholar 

  2. Tanne D, Yaari S, Goldbourt U (1997) High-density lipoprotein cholesterol and risk of ischemic stroke mortality. A 21-year follow-up of 8586 men from the Israeli Ischemic Heart Disease Study. Stroke 28:83–87

    PubMed  CAS  Google Scholar 

  3. Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, Eaton GM, Lauer MA, Sheldon WS, Grines CL, Halpern S, Crowe T, Blankenship JC, Kerensky R (2003) Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA 290:2292–2300

    Article  PubMed  CAS  Google Scholar 

  4. Shah PK, Kaul S, Nilsson J, Cercek B (2001) Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing is coming, part I. Circulation 104:2376–2383

    PubMed  CAS  Google Scholar 

  5. Brown BG, Zhao X-Q, Sacco DE, Albers JJ (1993) Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation 87:1781–1791

    PubMed  CAS  Google Scholar 

  6. Pulido MA, Angiolillo DJ, Costa MA (2004) Imaging of atherosclerotic plaque. Int J Cardiovasc Imaging 20:553–559

    Article  PubMed  Google Scholar 

  7. Yuan C, Petty C, O’Brien KD, Hatsukami TS, Eary JF, Brown BG (1997) In vitro and in situ magnetic resonance imaging signal features of atherosclerotic plaque-associated lipids. Atheroscler Throm Vasc Biol 17:1496–1503

    CAS  Google Scholar 

  8. Yuan C, Beach KW, Smith LH, Hatsukami TS (1998) Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging. Circulation 98:2666–2671

    PubMed  CAS  Google Scholar 

  9. Skinner MP, Yuan C, Mitsumori L, Hayes CE, Raines EW, Nelson JA, Ross R (1995) Serial magnetic resonance imaging of experimental atherosclersis detects lesion fine structure, progession and complication in vivo. Nat Med 1:69–73

    Article  PubMed  Google Scholar 

  10. Zhao XQ, Chun Y, Frechette EH, Maravilla KR, Brown BG (2001) Effects of intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques by MRI: A Case-control Study. Arterioscler Thromb Vasc Biol 21:1623–1629

    PubMed  CAS  Google Scholar 

  11. Corti R, Fayad ZA, Fuster V, Worthley SG, Helft G, Chesebro J, Mercuri M, Badimon JJ (2001) Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 104:249–252

    PubMed  CAS  Google Scholar 

  12. Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Serafini L, Huss-Frechette E, Wang S, DeAngelis D, Dodek A, Albers JJ (2001) Simvastatin and Niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345:1583–1592

    Article  PubMed  CAS  Google Scholar 

  13. Hayes CE, Mathis CM, Yuan C (1996) Surface coil phased arrays for high resolution imaging of carotid arteries. J Magn Reson Imaging 6:109–112

    Article  PubMed  CAS  Google Scholar 

  14. Kerwin WS, Han C, Chu B, Xu D, Luo Y, Hwang JN, Hatsukami TS, Yuan C (2001) A quantitative vascular analysis system for evaluation of atherosclerotic lesions by MRI. In: Medical Image Computing and Computer-Assisted Intervention-MICCAI 2001. Springer, Berlin, Germany, pp 786–794

  15. Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C (2002) Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 106:1368–1373

    Article  PubMed  Google Scholar 

  16. Toussaint JF, LaMuraglia GM, Southern JF, Fuster V, Kantor HL (1996) Magnetic resonance images lipid, fibrous, calcified, hemorrhagic, and thrombotic components of human atherosclerosis in vivo. Circulation 94:932–938

    PubMed  CAS  Google Scholar 

  17. Saam T, Ferguson MS, Yarnykh VL, Takaya N, Xu D, Polissar NL, Hatsukami TS, Yuan C (2005) Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol 25:234–239

    PubMed  CAS  Google Scholar 

  18. Kannel WB (1983) High-density lipoproteins: epidemiologic profile and risks of coronary artery disease. Am J Cardiol 52:9–12

    Article  Google Scholar 

  19. Mathiesen EB, Bonaa KH, Joakimsen O (2001) Low levels of high-density lipoprotein cholesterol are associated with echolucent carotid artery plaques: the Tromso study. Stroke 32:1960–1965

    PubMed  CAS  Google Scholar 

  20. Baldassarre D, Amato M, Pustina L, Tremoli E, Sirtori CR, Calabresi L, Franceschini G (2002) Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia. Arterioscler Thromb Vasc Biol 22:317–322

    Article  PubMed  CAS  Google Scholar 

  21. Spady DK (1999) Reverse cholesterol transport and atherosclerosis regression. Circulation 100: 576–578

    PubMed  CAS  Google Scholar 

  22. Chiesa G, Monteggia E, Marchesi M, Lorenzon P, Laucello M, Lorusso V, Di Mario C, Karvouni E, Newton RS, Bisgaier CL, Franceschini G, Sirtori CR (2002) Recombinant apolipoprotein A-I(Milano) infusion into rabbit carotid artery rapidly removes lipid from fatty streaks. Circ Res 90:974–980

    Article  PubMed  CAS  Google Scholar 

  23. Summary of the Second Report of the National Cholesterol Education Program (NCEP) (1993) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 269:3015–3023

    Google Scholar 

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103-8771, USA

    Binh An P. Phan & Xue-Qiao Zhao

  2. Department of Radiology, University of Washington, Seattle, WA, USA

    Baocheng Chu & Chun Yuan

  3. The Mountain-Whisper-Light Statistical Consulting, Seattle, WA, USA

    Nayak Polissar

  4. Department of Surgery, University of Washington and VA Puget Sound Health Care System, Seattle, WA, USA

    Thomas S. Hatsukami

Authors
  1. Binh An P. Phan
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  2. Baocheng Chu
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  3. Nayak Polissar
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  4. Thomas S. Hatsukami
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  5. Chun Yuan
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  6. Xue-Qiao Zhao
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Correspondence to Binh An P. Phan.

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Phan, B.A.P., Chu, B., Polissar, N. et al. Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging. Int J Cardiovasc Imaging 23, 337–342 (2007). https://doi.org/10.1007/s10554-006-9175-7

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  • DOI: https://doi.org/10.1007/s10554-006-9175-7

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