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Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk

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Abstract

Purpose

Insulin-like growth factor 1 (IGF1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of IGF1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer.

Methods

In this ongoing colorectal cancer study of Austria (CORSA), a total of 3,360 Caucasian participants, consisting of 178 colorectal cancer patients, 328 patients with high risk polyps, 1,059 patients with low risk colorectal polyps, and 1,795 colonoscopy-negative controls, were recruited within a large colorectal screening project in the province Burgenland and from three hospitals in Vienna. Multiple logistic regression was applied to compare individuals of the control group against three different risk groups, namely, colorectal cancer group, high risk polyp group, and low risk polyp group.

Results

Carriers of the homozygous polymorphic genotype of the SNP rs6214 were associated with an increased colorectal risk (OR = 1.79, 95% CI 1.04–1.90) compared to the colonoscopy-negative controls; this was also found when combining colorectal cancer cases and high risk polyp group (OR = 1.39, 95% CI 1.01–1.90).

Conclusion

Our results suggest that the SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements.

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Abbreviations

CRC:

Colorectal cancer

CORSA:

Colorectal cancer study of Austria

IGF1:

Insulin-like growth factor 1

IGFBP3:

Insulin-like growth factor binding protein 3

SNP:

Single nucleotide polymorphism

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Acknowledgments

We thank Marlies Pusman for excellent recruitment of patients and Martin Preyer for genotyping. Furthermore, we thank all physicians involved in this study for data management and blood sampling. This study was supported by a grant from “Österreichische Krebshilfe.”

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Authors and Affiliations

  1. Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria

    Elisabeth Feik, Barbara Hieger, Gerhard Führlinger, Astrid Pentz, Michael Micksche & Andrea Gsur

  2. Department of Statistics and Decision Support Systems, University of Vienna, Vienna, Austria

    Andreas Baierl

  3. Department of Surgery, SMZ Süd, Vienna, Austria

    Stefan Stättner

  4. Department of Gastroenterology, Rudolfstiftung, Vienna, Austria

    Werner Weiss & Thomas Pulgram

  5. Hospital Oberpullendorf, Burgenland, Austria

    Gernot Leeb & Karl Mach

Authors
  1. Elisabeth Feik
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  2. Andreas Baierl
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  3. Barbara Hieger
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  4. Gerhard Führlinger
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  5. Astrid Pentz
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  6. Stefan Stättner
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  7. Werner Weiss
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  8. Thomas Pulgram
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  9. Gernot Leeb
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  10. Karl Mach
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  11. Michael Micksche
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  12. Andrea Gsur
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Corresponding author

Correspondence to Andrea Gsur.

Additional information

The study was approved by the institutional review boards at the Medical University of Vienna and Burgenland.

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Feik, E., Baierl, A., Hieger, B. et al. Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk. Cancer Causes Control 21, 91–97 (2010). https://doi.org/10.1007/s10552-009-9438-4

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  • DOI: https://doi.org/10.1007/s10552-009-9438-4

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