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Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d’Ivoire and Finland) with different tobacco exposure

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Abstract

Our objective was to compare the association between tobacco smoking and chewing and the risk of multiple human papillomavirus (HPV) infections and cervical squamous intraepithelial lesions (SILs) in two populations with different tobacco exposure. We studied 2,162 women from Côte d’Ivoire, West Africa, and 419 women from Finland, Northern Europe, with baseline data on cervical screening, HPV DNA status and smoking and chewing habits. The proportion of women who smoked and/or chewed tobacco was higher in Finland (36.8%) than in Côte d’Ivoire (3.7%), where tobacco chewing (2.6%) was more common than tobacco smoking (1.4%). Having multiple HPV infections was common in HPV16 and/or 18-infected women (60.4% in Finland and 47.2% in Côte d’Ivoire). There was no increased risk of multiple HPV infections among tobacco consumers. We found that women ≥30 years of age exposed to tobacco through smoking in Finland (OR: 2.2, 95% CI: 0.5–8.7) and chewing in Côte d’Ivoire (OR: 5.5, 95% CI: 2.1–14) had a moderately or highly increased risk of high-grade SIL, respectively. In the latter, the risk was statistically significant. Our findings emphasize the need for health initiatives targeted to prevent tobacco smoking or chewing among women especially in less industrialized countries.

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Acknowledgment

This study was supported by a grant from the Cancer Control using Population-based Registries and Biobanks (CCPRB) European Union Network. The study conducted in Cote d’Ivoire was supported by grants from the French Agence Nationale de Recherches sur le Sida (ANRS) and the French Ministry of Cooperation.

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Authors and Affiliations

  1. Department of Child and Adolescent Health, National Public Health Institute, P.O. Box 310, Oulu, 90101, Finland

    Aline Simen-Kapeu & Matti Lehtinen

  2. Programme National de Lutte Contre le SIDA, Abidjan, Côte d’Ivoire

    Guy La Ruche

  3. Department of Oncology, Kuopio University Hospital, Kuopio, Finland

    Vesa Kataja

  4. Vaasa Central Hospital, Vaasa, Finland

    Vesa Kataja

  5. Central Hospital of Central Finland, Jyväskylä, Finland

    Merja Yliskoski

  6. Laboratoire Pasteur-Cerba, Cergy-Pontoise, Paris, France

    Christine Bergeron

  7. Département de Gynécologie et Obstétrique, Centre Hospitalier et Universitaire de Yopougon, Abidjan, Côte d’Ivoire

    Apollinaire Horo

  8. Turku University Hospital, Turku, Finland

    Kari Syrjänen

  9. Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland

    Seppo Saarikoski

  10. School of Public Health, University of Tampere, Tampere, Finland

    Matti Lehtinen

  11. Unité INSERM 897, Université Victor Segalen Bordeaux 2, Bordeaux, France

    François Dabis & Annie J. Sasco

Authors
  1. Aline Simen-Kapeu
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  2. Guy La Ruche
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  3. Vesa Kataja
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  6. Apollinaire Horo
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  8. Seppo Saarikoski
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  9. Matti Lehtinen
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  10. François Dabis
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  11. Annie J. Sasco
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Correspondence to Aline Simen-Kapeu.

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Simen-Kapeu, A., La Ruche, G., Kataja, V. et al. Tobacco smoking and chewing as risk factors for multiple human papillomavirus infections and cervical squamous intraepithelial lesions in two countries (Côte d’Ivoire and Finland) with different tobacco exposure. Cancer Causes Control 20, 163–170 (2009). https://doi.org/10.1007/s10552-008-9230-x

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  • DOI: https://doi.org/10.1007/s10552-008-9230-x

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