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Serum triglycerides and colorectal adenoma in a case–control study among cancer screening examinees (Japan)

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Abstract

Objective

Most epidemiologic studies have shown serum triglycerides to be associated with colorectal adenoma. However, whether the association can be modified by smoking is unknown. We cross-sectionally investigated the association of serum triglycerides with the risk of adenoma by smoking status.

Methods

We identified 782 newly diagnosed adenoma cases from the examinees of a colorectal cancer screening program. All cases were diagnosed by a magnifying colonoscopy with dye spreading. We determined 738 controls without present illness or past history of adenoma from among the examinees. They provided their lifestyle information and fasting blood samples to measure their serum triglycerides. We calculated odds ratios (OR) and 95% confidence intervals (CI) of colorectal adenoma for serum triglycerides.

Results

High serum triglycerides were associated with colorectal adenoma (OR 1.5; 95% CI 1.1–2.0 for the highest versus the lowest quartile, P trend, 0.030). A stronger association was observed between three or more adenoma cases and study controls (OR 2.3; 95% CI 1.3–4.2, P trend, < 0.0010). After classifying the study subjects by smoking status, a significant linear risk trend was found in ever-smokers (P trend, 0.0018) but not in never-smokers (P trend, 0.94; P interaction, 0.067).

Conclusions

Our results suggested that a higher serum triglyceride level may be related to a larger number of adenomas. Adenoma development involving an elevated serum triglyceride level may be modified by smoking.

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Acknowledgments

We thank Dr. Yasushi Sano, Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, for his helpful comments. This study was supported by a Grant-in-Aid for Cancer Research and for the Third-Term Comprehensive 10-year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan, by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by the program for promotion of Fundamental Studies in Health Sciences of the Pharmaceuticals and Medical Devices Agency (PMDA).

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Authors and Affiliations

  1. Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Txokyo, Japan 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Tetsuya Otani, Motoki Iwasaki, Shinobu Ikeda & Shoichiro Tsugane

  2. Cancer Screening Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

    Takahiro Kozu

  3. Cancer Screening Technology Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

    Hiroshi Saito

  4. Cancer Prevention Basic Research Project, National Cancer Center Institute, Tokyo, Japan

    Michihiro Mutoh & Keiji Wakabayashi

Authors
  1. Tetsuya Otani
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  2. Motoki Iwasaki
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  3. Shinobu Ikeda
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  4. Takahiro Kozu
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  8. Shoichiro Tsugane
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Correspondence to Tetsuya Otani.

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Otani, T., Iwasaki, M., Ikeda, S. et al. Serum triglycerides and colorectal adenoma in a case–control study among cancer screening examinees (Japan). Cancer Causes Control 17, 1245–1252 (2006). https://doi.org/10.1007/s10552-006-0065-z

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  • DOI: https://doi.org/10.1007/s10552-006-0065-z

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