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Alcohol consumption, smoking, and invasive breast cancer risk after ductal carcinoma in situ

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Purpose

Alcohol is an established risk factor for invasive breast cancer, and women with a prior ductal carcinoma in situ diagnosis are at higher risk of invasive breast cancer than the general population. However, for women with a prior ductal carcinoma in situ diagnosis, few studies have evaluated the association between alcohol and smoking and risk of subsequent invasive breast cancer.

Methods

Utilizing a population-based case–control design nested among women diagnosed with a ductal carcinoma in situ between 1995 and 2013, we compared 243 cases diagnosed with a subsequent invasive breast cancer and 423 individually matched controls never diagnosed with a subsequent breast cancer.

Results

Compared with never to occasional drinkers, drinkers consuming at least 7 alcoholic drinks per week on average at ductal carcinoma in situ diagnosis had a higher risk of invasive breast cancer that was borderline significant (OR 1.79, 95% CI 1.01–3.17, P value = 0.04). Smoking was not significantly associated with risk of developing an invasive breast cancer after adjustment for alcohol consumption.

Conclusions

These findings suggest that consuming at least one alcoholic drink per day on average is positively associated with invasive breast cancer for women with a prior ductal carcinoma in situ diagnosis. If confirmed, modulating alcohol consumption could be one strategy for women with a history of ductal carcinoma in situ to impact their risk of invasive breast cancer.

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Data availability

The datasets generated and/or analyzed during the current study are not publicly available because consent was not obtained from study participants to make these data publicly available, but de-identified data are available from the corresponding author on reasonable request.

Abbreviations

DCIS:

Ductal carcinoma in situ

OR:

Odds ratio

CI:

Confidence interval

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Acknowledgments

We want to acknowledge the time and generosity of all of the breast cancer patients who participated in this research.

Funding

This work was supported by the National Cancer Institute at the National Institutes of Health (R01-CA097271) and a National Cancer Institute at the National Institutes of Health training grant (T32-CA094880) to KMJ.

Author information

Authors and Affiliations

  1. Department of Epidemiology, University of Washington, Seattle, WA, USA

    Kristina M. Jordahl

  2. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Kristina M. Jordahl, Kathleen E. Malone, Michelle L. Baglia, Meghan R. Flanagan, Mei-Tzu C. Tang, Peggy L. Porter & Christopher I. Li

  3. Department of Surgery, University of Washington, Seattle, WA, USA

    Meghan R. Flanagan

  4. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA

    Peggy L. Porter

Authors
  1. Kristina M. Jordahl
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  2. Kathleen E. Malone
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  3. Michelle L. Baglia
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  4. Meghan R. Flanagan
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  5. Mei-Tzu C. Tang
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  6. Peggy L. Porter
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  7. Christopher I. Li
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Contributions

KMJ contributed to conceptualization, data curation, formal analysis, methodology, writing—original draft, and writing—review and editing. KEM contributed to conceptualization, funding acquisition, investigation, methodology, resources, and writing—review and editing. MLBcontributed to data curation and writing—review and editing. MRF contributed to conceptualization and writing—review and editing. MCT contributed to data curation, formal analysis, methodology, validation, and writing—review and editing. PLP contributed to conceptualization, funding acquisition, and writing—review and editing. CIL contributed to conceptualization, funding acquisition, investigation, methodology, project administration, resources, supervision, writing—original draft, and writing—review and editing.

Corresponding author

Correspondence to Christopher I. Li.

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Conflict of interest

The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health’s National Cancer Institute. The authors declare that they have no relevant financial or non-financial interests to disclose.

Ethical approval and consent to participate

This study received human subjects approval for all activities through the Fred Hutchinson Cancer Research Center Institutional Review Board. All alive patients provided their active consent for participating and deceased patients were enrolled through an approved waiver of consent.

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Jordahl, K.M., Malone, K.E., Baglia, M.L. et al. Alcohol consumption, smoking, and invasive breast cancer risk after ductal carcinoma in situ. Breast Cancer Res Treat 193, 477–484 (2022). https://doi.org/10.1007/s10549-022-06573-9

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  • DOI: https://doi.org/10.1007/s10549-022-06573-9

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