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Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study

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Abstract

Purpose

Alcohol is an established breast cancer risk factor, but there is little evidence on whether the association differs between African Americans and whites.

Methods

Invasive breast cancers (n = 1,795; 1,014 white, 781 African American) and age- and race-matched controls (n = 1,558; 844 white, 714 African American) from the Carolina Breast Cancer Study (Phases I–II) were used to estimate odds ratios (ORs) and 95 % confidence interval (CI) for pre-diagnosis drinks per week and breast cancer risk.

Results

African American controls reported lower alcohol intake than white controls across all age groups. Light drinking (0 to ≤2 per week) was more prevalent among African American controls. Moderate-to-heavy drinking was more prevalent in white controls. African Americans who reported drinking >7 drinks per week had an elevated risk compared to light drinkers [adjusted OR, 95% CI 1.62 (1.03–2.54)]. A weaker association was observed among whites [adjusted OR, 95% CI 1.20 (0.87–1.67)]. The association of >7 drinks per week with estrogen receptor-negative [adjusted OR, 95% CI 2.17 (1.25–3.75)] and triple-negative [adjusted OR, 95% CI 2.12 (1.12–4.04)] breast cancers was significant for African American, but not white women. We observed significantly elevated ORs for heavy intake at ages <25 and >50 years of age for African American women only. We found no evidence of statistical interaction between alcohol intake and oral contraceptive use or smoking.

Conclusions

Drinking more than seven alcoholic beverages per week increased invasive breast cancer risk among white and African American women, with significant increases only among African American women. Genetic or environmental factors that differ by race may mediate the alcohol–breast cancer risk association.

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References

  1. Li CI, Chlebowski RT, Freiberg M et al (2010) Alcohol consumption and risk of postmenopausal breast cancer by subtype: the women’s health initiative observational study. J Natl Cancer Inst 102(18):1422–1431. doi:10.1093/jnci/djq316

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  2. Tjønneland A, Christensen J, Olsen A et al (2007) Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control CCC. 18(4):361–373. doi:10.1007/s10552-006-0112-9

    Article  PubMed  Google Scholar 

  3. Allen NE, Beral V, Casabonne D et al (2009) Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst 101(5):296–305. doi:10.1093/jnci/djn514

    Article  PubMed  Google Scholar 

  4. Longnecker MP, Berlin JA, Orza MJ, Chalmers TC (1988) A meta-analysis of alcohol consumption in relation to risk of breast cancer. JAMA J Am Med Assoc 260(5):652–656

    Article  CAS  Google Scholar 

  5. Bowlin SJ, Leske MC, Varma A, Nasca P, Weinstein A, Caplan L (1997) Breast cancer risk and alcohol consumption: results from a large case–control study. Int J Epidemiol 26(5):915–923. doi:10.1093/ije/26.5.915

    Article  PubMed  CAS  Google Scholar 

  6. Kinney AY, Millikan RC, Lin YH, Moorman PG, Newman B (2000) Alcohol consumption and breast cancer among black and white women in North Carolina (United States). Cancer Causes Control CCC 11(4): 345–357. http://www.ncbi.nlm.nih.gov/pubmed/10843445

  7. Terry MB, Zhang FF, Kabat G et al (2006) Lifetime alcohol intake and breast cancer risk. Ann Epidemiol 16(3):230–240. doi:10.1016/j.annepidem.2005.06.048

    Article  PubMed  Google Scholar 

  8. Llanos AA, Makambi KH, Tucker CA, Shields PG, Adams-Campbell LL (2012) Alcohol, anthropometrics, and breast cancer risk in African American women. Breast J 18(4):394–395. doi:10.1111/j.1524-4741.2012.01265.x

    Article  PubMed  PubMed Central  Google Scholar 

  9. Volcik KA, Ballantyne CM, Fuchs FD, Sharrett AR, Boerwinkle E (2008) Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC study. Ann Epidemiol 18(2):101–107. doi:10.1016/j.annepidem.2007.07.103

    Article  PubMed  PubMed Central  Google Scholar 

  10. Jackson CL, Hu FB, Kawachi I, Williams DR, Mukamal KJ, Rimm EB (2015) Black-White differences in the relationship between alcohol drinking patterns and mortality among US men and women. Am J Public Health 105(S3):S534–S543. doi:10.2105/AJPH.2015.302615

    Article  PubMed  Google Scholar 

  11. Darrow SL, Russell M, Cooper ML, Mudar PJ, Frone M (1992) Sociodemographic correlates of alcohol consumption among African–American and White Women. Women Health 18(4):1–15. doi:10.1300/J013v18n04

    Article  Google Scholar 

  12. Seitz HK, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7(8):599–612. doi:10.1038/nrc2191

    Article  PubMed  CAS  Google Scholar 

  13. Suzuki R, Orsini N, Mignone L, Saji S, Wolk A (2008) Alcohol intake and risk of breast cancer defined by estrogen and progesterone receptor status—a meta-analysis of epidemiological studies. Int J Cancer 122(8):1832–1841. doi:10.1002/ijc.23184

    Article  PubMed  CAS  Google Scholar 

  14. Watabiki T, Okii Y, Tokiyasu T et al (2004) Long-term ethanol consumption in ICR mice causes mammary tumor in females and liver fibrosis in males. Alcohol Clin Exp Res 24(4 Suppl):117S–122S

    Google Scholar 

  15. Reichman ME, Judd T, Longcope C et al (1993) Effects of alcohol consumption on plasma and urinary hormone concentration in premenopausal women. J Natl Cancer Inst 85(9):722–727

    Article  PubMed  CAS  Google Scholar 

  16. Newman B, Moorman PG, Millikan R, et al (1995) The Carolina Breast Cancer Study: integrating population-based epidemiology and molecular biology. Breast Cancer Res Treat 35(1): 51–60. http://www.ncbi.nlm.nih.gov/pubmed/7612904

  17. Razzaghi H, Troester MA, Gierach GL, Olshan AF, Yankaskas BC, Millikan RC (2012) Mammographic density and breast cancer risk in White and African American Women. Breast Cancer Res Treat 135(2):571–580. doi:10.1007/s10549-012-2185-3

    Article  PubMed  PubMed Central  Google Scholar 

  18. Conway K, Parrish E, Edmiston SN et al (2007) Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation. Breast Cancer Res BCR 9(3):R36. doi:10.1186/bcr1731

    Article  PubMed  Google Scholar 

  19. O’Brien KM, Cole SR, Tse C-K et al (2010) Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clinical Cancer Res 16(24):6100–6110. doi:10.1158/1078-0432.CCR-10-1533

    Article  Google Scholar 

  20. Millikan RC, Newman B, Tse C-K et al (2008) Epidemiology of basal-like breast cancer. Breast Cancer Res Treat 109(1):123–139. doi:10.1007/s10549-007-9632-6

    Article  PubMed  PubMed Central  Google Scholar 

  21. Carey LA, Perou CM, Livasy CA et al (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. J Am Med Assoc 295(21):2492–2502. doi:10.1001/jama.295.21.2492

    Article  CAS  Google Scholar 

  22. Hall IJ, Moorman PG, Millikan RC, Newman B (2005) Comparative analysis of breast cancer risk factors among African–American women and white women. Am J Epidemiol 161(1):40–51. doi:10.1093/aje/kwh331

    Article  PubMed  Google Scholar 

  23. O’Brien KM, Cole SR, Tse C-K et al (2010) Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clinical Cancer Res 16(24):6100–6110. doi:10.1158/1078-0432.CCR-10-1533

    Article  Google Scholar 

  24. Dietary Guidelines for Americans (2010) Health and human services. www.dietaryguidelines.gov

  25. Greenland S, Pearl J, Robins JM (1999) Causal diagrams for epidemiologic research. Epidemiology 10(1):37–48

    Article  PubMed  CAS  Google Scholar 

  26. Falk RT, Maas P, Schairer C et al (2014) Alcohol and risk of breast cancer in postmenopausal women: an analysis of etiological heterogeneity by multiple tumor characteristics. Am J Epidemiol 180(7):705–717. doi:10.1093/aje/kwu189

    Article  PubMed  PubMed Central  Google Scholar 

  27. Fagherazzi G, Vilier A, Boutron-Ruault M-C, Mesrine S, Clavel-Chapelon F (2014) Alcohol consumption and breast cancer risk subtypes in the E3N-EPIC cohort. Eur J Cancer Prev. doi:10.1097/CEJ.0000000000000031

    Google Scholar 

  28. Hamajima N, Hirose K, Tajima K et al (2002) Alcohol, tobacco and breast cancer–collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 87(11):1234–1245. doi:10.1038/sj.bjc.6600596

    Article  PubMed  CAS  Google Scholar 

  29. Chen W, Rosner B, Hankinson SE, Colditz GA, Willett WC (2011) Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. Breast Dis Year Book Q 23(3):231–232. doi:10.1016/j.breastdis.2012.06.010

    Google Scholar 

  30. Caetano R, Herd D (1984) Black drinking practices in Northern California. Am J Drug Alcohol Abuse 10(4):571–587

    Article  PubMed  CAS  Google Scholar 

  31. Kabat GC, Kim M, Phipps AI et al (2012) Smoking and alcohol consumption in relation to risk of triple-negative breast cancer in a cohort of postmenopausal women. Cancer Causes Control CCC. 22(5):775–783. doi:10.1007/s10552-011-9750-7

    Article  Google Scholar 

  32. Singletary KW, Gapstur SM (2001) Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA J Am Med Assoc 286(17):2143–2151

    Article  CAS  Google Scholar 

  33. Dumeaux V, Lund E, Hjarta A (2004) Use of oral contraceptives, alcohol, and risk for invasive breast cancer. Cancer Epidemiol Biomark Prev 13(August):1302–1307

    CAS  Google Scholar 

  34. Edenberg HJ, Xuei X, Chen H-J et al (2006) Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet 15(9):1539–1549. doi:10.1093/hmg/ddl073

    Article  PubMed  CAS  Google Scholar 

  35. Edenberg HJ (2007) The genetics of alcohol metabolism. Alcohol Res Health 30(1):5–13

    PubMed  PubMed Central  Google Scholar 

  36. Giovannucci E, Stampfer MJ, Colditz GA, et al (1993) Recall and selection bias in reporting past alcohol consumption among breast cancer cases. Cancer Causes Control CCC 4(5): 441–448. http://www.ncbi.nlm.nih.gov/pubmed/8218876

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Acknowledgments

This research was supported by a breast Specialized Program of Research Excellence (SPORE) Grant (P50-CA58223) and by the North Carolina State University Cancer Research Fund.

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Authors and Affiliations

  1. Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, Campus Box 7435, Chapel Hill, NC, 27599, USA

    Lindsay A. Williams, Andrew F. Olshan, Chui Kit Tse & Melissa A. Troester

  2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC, 27514, USA

    Andrew F. Olshan, Mary Elizabeth Bell & Melissa A. Troester

Authors
  1. Lindsay A. Williams
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  2. Andrew F. Olshan
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Correspondence to Melissa A. Troester.

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Williams, L.A., Olshan, A.F., Tse, C.K. et al. Alcohol intake and invasive breast cancer risk by molecular subtype and race in the Carolina Breast Cancer Study. Cancer Causes Control 27, 259–269 (2016). https://doi.org/10.1007/s10552-015-0703-4

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