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New emerging roles of microRNAs in breast cancer

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  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Background

MicroRNAs constitute a large family of non-coding RNAs, which actively participate in tumorigenesis by regulating a set of mRNAs of distinct signaling pathways. An altered expression of these molecules has been found in different tumorigenic processes of breast cancer, the most common type of cancer in the female population worldwide.

Purpose

The objective of this review is to discuss how miRNAs become master regulators in breast tumorigenesis.

Methods

An integrative review of miRNAs and breast cancer literature from the last 5 years was done on PubMed. We summarize recent works showing that the defects on the biogenesis of miRNAs are associated with different breast cancer characteristics. Then, we show several examples that demonstrate the link between cellular processes regulated by miRNAs and the hallmarks of breast cancer. Finally, we examine the complexity in the regulation of these molecules as they are modulated by other non-coding RNAs and the clinical applications of miRNAs as they could serve as good diagnostic and classification tools.

Conclusion

The information presented in this review is important to encourage new directed studies that consider microRNAs as a good tool to improve the diagnostic and treatment alternatives in breast cancer.

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Abbreviations

BC:

Breast cancer

TNBC:

Triple-negative breast cancer

EMT:

Epithelial-to-mesenchymal transition

BCSC:

Breast cancer stem cells

EGR1:

Early growth response protein 1

SOCS1:

Suppressor of cytokine signaling 1

CDKN1B:

Cyclin-dependent kinase inhibitor 1B

STAT5A:

Signal transducer and activator of transcription 5a

PTEN:

Phosphatase and tensin homolog

Akt:

Protein kinase B

Bcl-w:

Bcl-2-like protein 2

ERα:

Estrogen receptor alpha

E2F3:

E2F Transcription factor 3

SMAD7:

Mothers against decapentaplegic homolog 7

CDK8:

Cyclin-dependent kinase 8

BNDF:

Brain-derived neurotrophic factor

SIAH1:

Siah E3 ubiquitin protein ligase 1

MCL-1:

Induced myeloid leukemia cell differentiation protein

ADIPOR1:

Adiponectin receptor 1

TRPS1:

Transcriptional repressor GATA binding 1

ADAM-17:

ADAM metallopeptidase domain 17

uPAR7b:

uPAR isoform 2

NIM:

N-Myc interactor

NOV/CCN3:

Nephroblastoma overexpressed

ERBB3:

Erb-B2 receptor tyrosine kinase 3

Kras:

Proto-oncogene for Kirsten rat sarcoma viral oncogene

MMP9:

Matrix metallopeptidase 9

CXCR4:

C-X-C chemokine receptor type 4

ZBTB10:

Zinc finger and BTB domain containing 10

Ang2:

Angiopoietin-2

IL8:

Interleukin 8

CXCL1:

Chemokine (C-X-C motif) ligand 1

VHL:

Von Hippel–Lindau tumor suppressor

hTERT:

Human telomerase reverse transcriptase

C/EBPβ:

CCAAT/enhancer-binding protein beta

LDHA:

Lactate dehydrogenase A

PK:

Pyruvate kinase

ERRγ:

Estrogen-related receptor gamma

GABPA:

GA-binding protein alpha

ISCU:

Iron–sulfur cluster assembly enzyme

MiCB:

MHC class I polypeptide-related sequence B

TERF1:

Telomeric repeat-binding factor 1

FOXO3a:

Forkhead box O3

BRCA1:

Breast cancer type 1 susceptibility protein

NFKB:

Nuclear factor kappa B

OxPhos:

Oxidative phosphorylation

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  1. Edna Ayerim Mandujano-Tinoco

    Present address: Laboratory of Connective Tissue, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”. Calz., México-Xochimilco 289, Arenal de Guadalupe, 14389, Mexico, CDMX, Mexico

Authors and Affiliations

  1. Epigenetics Laboratory, Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, 14610, Mexico, CDMX, Mexico

    Edna Ayerim Mandujano-Tinoco, Alfredo García-Venzor & Vilma Maldonado

  2. Functional Genomics Laboratory, Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, 14610, Mexico, CDMX, Mexico

    Jorge Melendez-Zajgla

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  1. Edna Ayerim Mandujano-Tinoco
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  2. Alfredo García-Venzor
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  3. Jorge Melendez-Zajgla
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  4. Vilma Maldonado
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EAMT drafted the manuscript and edited the figures. AGV, JMZ, and VML helped to edit and review the manuscript. All authors read and approved the final version of the article.

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Correspondence to Vilma Maldonado.

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Mandujano-Tinoco, E.A., García-Venzor, A., Melendez-Zajgla, J. et al. New emerging roles of microRNAs in breast cancer. Breast Cancer Res Treat 171, 247–259 (2018). https://doi.org/10.1007/s10549-018-4850-7

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