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A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago

  • Epidemiology
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Abstract

The mortality rate from breast cancer in the nation of Trinidad and Tobago is among the highest of any country in the Caribbean region. The contribution of inherited gene mutations to the burden of breast cancer in Trinidad and Tobago has not been studied. We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago. We studied 268 unselected breast cancer patients from Trinidad and Tobago and looked for mutations across the entire coding sequences of BRCA1, BRCA2, and PALB2. Overall, 28 of 268 patients (10.4 %) had a mutation in one of the three genes, including 15 in BRCA1, ten in BRCA2, two in PALB2, and one in both BRCA2 and PALB2. There were 25 different mutations identified; of these, four mutations were seen in two patients each. Given the high prevalence of mutations, it is reasonable to offer genetic testing for these three genes to all breast cancer patients in Trinidad and Tobago.

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Acknowledgments

This research was supported by the grant from Susan G. Komen® KG11-0017. The authors thank the staff of the North West Regional Health Authority: Dr. Dylan Narinesingh, Dr. Cemonne Nixon, Dr. Jamie Morton-Gittens, Dr. Navin Sookar, Dr. Zahir Mohammed, Dr. Suzanne Chapman. The authors would also like to thank Nurse Patrice Carrington and Nurse Netasha Celestine.

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Authors and Affiliations

  1. Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue, D8-4, Miami, FL, 33136, USA

    Talia Donenberg, Sophia George & Judith Hurley

  2. Women’s College Research Institute, University of Toronto, Toronto, Canada

    Humayun Ahmed, Robert Royer, Shiyu Zhang, Steven A. Narod & Mohammad R. Akbari

  3. Institute of Medical Science, University of Toronto, Toronto, Canada

    Humayun Ahmed, Steven A. Narod & Mohammad R. Akbari

  4. Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

    Steven A. Narod & Mohammad R. Akbari

  5. Breast Surgery Unit, St. James Medical Complex, Northwest Regional Health Authority, Trinidad and Tobago, Division of General and Breast Surgery, University of Toronto, Toronto, Canada

    Jameel Ali

Authors
  1. Talia Donenberg
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  2. Humayun Ahmed
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  3. Robert Royer
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  4. Shiyu Zhang
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  5. Steven A. Narod
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  6. Sophia George
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  7. Mohammad R. Akbari
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  8. Jameel Ali
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  9. Judith Hurley
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Correspondence to Judith Hurley.

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Donenberg, T., Ahmed, H., Royer, R. et al. A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago. Breast Cancer Res Treat 159, 131–138 (2016). https://doi.org/10.1007/s10549-016-3870-4

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  • DOI: https://doi.org/10.1007/s10549-016-3870-4

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