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CD24 polymorphisms in breast cancer: impact on prognosis and risk

  • Epidemiology
  • Published:
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Abstract

Overexpression of CD24 has a negative impact on breast cancer prognosis. We have recently reported that the CD24 codon 57 Val/Val genotype (rs52812045) is associated with pathologic complete response after neoadjuvant chemotherapy for primary breast cancer and correlates with intratumoral lymphocyte infiltrates. This study was performed to investigate the influence of CD24 polymorphisms on breast cancer prognosis and risk. A total of 2,514 patients and 4,858 controls recruited as part of the MARIE study, a population-based case–control study, were genotyped for two CD24 polymorphisms (rs52812045, rs3838646) using TaqMan custom genotyping assays. Associations with overall and breast cancer-specific survival were assessed using uni- and multivariable Cox regression models stratified by age at diagnosis and adjusted for prognostic factors. Conditional logistic regression analysis adjusted for major risk factors was used to estimate multivariable odds ratios for risk of putative allele carriers compared to wildtype carriers. CD24 Ala/Val was significantly associated with breast cancer prognosis [Val/Val hazard ratio (HR)adjusted = 1.52; 95 % confidence interval (CI): 1.00–2.30, p = 0.05 and HRadjusted = 1.83; 95 % CI: 1.10–3.05, p = 0.018 for all-cause and breast cancer-specific mortality, respectively). The association was significant only in patients with a BMI <25 and in those who received adjuvant chemotherapy. None of the CD24 alleles was associated with breast cancer risk. These results provide further evidence of the CD24 Val/Val genotype influencing outcome in primary breast cancer. Together with previous data of CD24 overexpression as a poor prognostic marker, the findings underline the biological importance of CD24 for breast cancer.

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Acknowledgments

This study was supported by a grant from the German Cancer Aid (Deutsche Krebshilfe).

Conflict of interest

None of the authors have any relevant conflicts of interest to disclose.

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Authors and Affiliations

  1. Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Katharina Buck

  2. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Petra Seibold & Jenny Chang-Claude

  3. Department of Cancer Epidemiology/Clinical Cancer Registry, University Cancer Center Hamburg (UCCH), Hamburg, Germany

    Dieter Flesch-Janys

  4. Department of Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Dieter Flesch-Janys

  5. Department of Obstetrics and Gynecology, University Hospital, University of Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Frederik Marmé

  6. National Center for Tumor Diseases (NCT), Department of Gynecologic Oncology, University of Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Andreas Schneeweiss & Frederik Marmé

  7. Division of Translational Immunology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Peter Altevogt

  8. Department of Molecular Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Barbara Burwinkel

  9. National Center for Tumor Diseases (NCT), Department of Medical Oncology, University of Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Dirk Jäger

  10. Department of Obstetrics and Gynecology, University Hospital, University of Heidelberg, Voßstr 9, 69115, Heidelberg, Germany

    Sarah Hug, Irmgard Ferschke, Christof Sohn, Andreas Schneeweiss, Barbara Burwinkel & Frederik Marmé

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  1. Katharina Buck
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Correspondence to Frederik Marmé.

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Buck, K., Hug, S., Seibold, P. et al. CD24 polymorphisms in breast cancer: impact on prognosis and risk. Breast Cancer Res Treat 137, 927–937 (2013). https://doi.org/10.1007/s10549-012-2325-9

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