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Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk

  • Epidemiology
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Abstract

MicroRNAs (miRNAs) are 20–22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within the two miRNAs are still unknown. In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk. We compared the genotype and allele frequencies of rs4636297 and rs41272366 in 2854 cases versus 3188 controls of the three study populations independently and combined. None of the performed analyses showed statistically significant results. In conclusion, our data suggest that the two genetic variants within miR-126 and miR-335 are not associated with breast cancer risk.

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Acknowledgments

This study was supported by the Dietmar-Hopp Foundation, the Helmholtz society and the German Cancer Research Center (DKFZ). The German breast cancer samples were collected within a project funded by the Deutsche Krebshilfe (Grant number: 107054). The VERDI study was supported by the Deutsche Krebshilfe (Grant number: M24/95/BRI). The ESTHER study was supported by a grant from the Baden-Württemberg Ministry of Science, Research, and Arts.

Author information

Authors and Affiliations

  1. Division Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, 69120, Heidelberg, Germany

    Rongxi Yang, Michelle Dick, Frederik Marme, Andreas Schneeweiss, Anne Langheinz, Sarah Schott, Christof Sohn & Barbara Burwinkel

  2. Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

    Rongxi Yang, Michelle Dick, Anne Langheinz & Barbara Burwinkel

  3. Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany

    Kari Hemminki

  4. Department of Biosciences at Novum, Karolinska Institute, 14157, Huddinge, Sweden

    Kari Hemminki

  5. Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany

    Christian Sutter & Claus R. Bartram

  6. Medical Faculty of Mannheim, Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden-Württemberg-Hessen, University of Heidelberg, Mannheim, Germany

    Peter Bugert

  7. Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, Clinical Center University of Cologne, 50931, Cologne, Germany

    Barbara Wappenschmidt & Rita K. Schmutzler

  8. Institute of Human Genetics, Charité, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany

    Raymonda Varon

  9. Institute of Human Genetics, University of Regensburg, 93053, Regensburg, Germany

    Bernhard H. F. Weber

  10. Division of Molecular Genetics, Department of Gynaecology and Obstetrics, Clinical Center University of Düsseldorf, 40225, Düsseldorf, Germany

    Dieter Niederacher

  11. Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig-Holstein, 24105, Kiel, Germany

    Norbert Arnold

  12. Department of Gynaecology and Obstetrics, Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany

    Alfons Meindl

  13. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Heiko Müller, Volker Arndt & Hermann Brenner

Authors
  1. Rongxi Yang
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  2. Michelle Dick
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  3. Frederik Marme
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  4. Andreas Schneeweiss
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  5. Anne Langheinz
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  6. Kari Hemminki
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  7. Christian Sutter
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  8. Peter Bugert
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  9. Barbara Wappenschmidt
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  10. Raymonda Varon
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  11. Sarah Schott
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  12. Bernhard H. F. Weber
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  13. Dieter Niederacher
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  14. Norbert Arnold
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  15. Alfons Meindl
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  16. Claus R. Bartram
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  17. Rita K. Schmutzler
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  18. Heiko Müller
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  19. Volker Arndt
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  20. Hermann Brenner
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  21. Christof Sohn
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  22. Barbara Burwinkel
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Corresponding author

Correspondence to Rongxi Yang.

Additional information

Rongxi Yang and Michelle Dick contributed equally to this study.

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Yang, R., Dick, M., Marme, F. et al. Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk. Breast Cancer Res Treat 127, 549–554 (2011). https://doi.org/10.1007/s10549-010-1244-x

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  • DOI: https://doi.org/10.1007/s10549-010-1244-x

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