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Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis

  • Epidemiology
  • Published:
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Abstract

Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the association between HPV infection and risk of breast carcinoma, the studies remain inconclusive. Here, a meta-analysis was conducted to estimate the prevalence of HPV in breast carcinoma and test the association. Studies on HPV DNA detection in sporadic breast carcinoma in female using polymerase chain reaction were included. Information on overall and type-specific (HPV 6, 11, 16, 18, 31, 33, 35, 45 and 51) HPV prevalence were required, plus detailed descriptions of study populations, HPV DNA source, publication calendar period and PCR primers used for HPV DNA detection and typing. We revealed that 24.49% of the breast carcinoma cases were associated with HPV, 32.42% occurred in Asia and 12.91% in Europe. The four most commonly identified HPV types, in the order of decreased prevalence, were HPV33, 18, 16, and 35. The detection of HPV was mostly influenced by publication calendar period and PCR primers used. In addition, the analysis of ten case–control studies containing 447 breast carcinoma cases and 275 controls showed a significant increase in breast carcinoma risk with HPV positivity (OR = 3.63, 95% CI = 1.42–9.27). These results suggest that it’s difficult to rule out the possibility of the association of HPV and breast carcinoma at present according to available publication proofs.

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Acknowledgments

This study is supported by the National Natural Science Fund 30901236 from National Natural Science Foundation of China and Fogarty Training Grant 1D43TW008323-01 from the National Institute of Health (NIH). All authors have made substantial contributions to the conception and design of the study, or acquisition of data, or analysis and interpretation of data, drafting of the article or revising it critically for important intellectual content, and final approval of the version submitted.

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All funding sources supporting the work and all institutional or corporate affiliations of the authors are acknowledged.

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Authors and Affiliations

  1. National Office for Cancer Prevention and Control, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, No. 17 Panjiayuannanli, Chaoyang District, Beijing, 100021, China

    Ni Li, Xiaofeng Bi, Ping Zhao & Min Dai

  2. School of Public Health, Yale University, New Haven, CT, 06520, USA

    Yawei Zhang & Tongzhang Zheng

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  1. Ni Li
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  2. Xiaofeng Bi
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  3. Yawei Zhang
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  4. Ping Zhao
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  6. Min Dai
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Correspondence to Min Dai.

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Li, N., Bi, X., Zhang, Y. et al. Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis. Breast Cancer Res Treat 126, 515–520 (2011). https://doi.org/10.1007/s10549-010-1128-0

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  • DOI: https://doi.org/10.1007/s10549-010-1128-0

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