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Human papillomavirus in breast cancer

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Summary

Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and thein situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences byin situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.

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Authors and Affiliations

  1. Lab. of Virology, CRS, Regina Elena Institute for Cancer Research, Via delle Messi d'Oro 156, 00158, Rome, Italy

    Anna Di Lonardo, Aldo Venuti & Maria Luisa Marcante

Authors
  1. Anna Di Lonardo
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  2. Aldo Venuti
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  3. Maria Luisa Marcante
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Di Lonardo, A., Venuti, A. & Marcante, M.L. Human papillomavirus in breast cancer. Breast Cancer Res Tr 21, 95–100 (1992). https://doi.org/10.1007/BF01836955

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